Recombinant yeast having enhanced xylose fermentation capabilities and methods of use

Sato, Trey Kyle; Piotrowski, Jeff Scott

Title: Recombinant yeast having enhanced xylose fermentation capabilities and methods of use

Patent · Tue Dec 17 00:00:00 EST 2019

OSTI ID:1600407

Sato, Trey Kyle; Piotrowski, Jeff Scott

The present invention relates to the production of biofuels and chemical feedstocks. The present invention provides recombinant yeast having enhanced xylose fermentation capabilities. Methods of using such recombinant yeast for improved biofuel and chemical feedstock production are also provided.

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Research Organization:: Wisconsin Alumni Research Foundation, Madison, WI (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FC02-07ER64494

Assignee:: Wisconsin Alumni Research Foundation (Madison, WI)

Patent Number(s):: 10,508,272

Application Number:: 14/683,724

OSTI ID:: 1600407

Resource Relation:: Patent File Date: 04/10/2015

Country of Publication:: United States

Language:: English

References (6)

Xylose fermentation by Saccharomyces cerevisiae K�tter, Peter; Ciriacy, Michael Applied Microbiology and Biotechnology, Vol. 38, Issue 6 https://doi.org/10.1007/BF00167144	journal	March 1993
Xylose isomerase overexpression along with engineering of the pentose phosphate pathway and evolutionary engineering enable rapid xylose utilization and ethanol production by Saccharomyces cerevisiae Zhou, Hang; Cheng, Jing-sheng; Wang, Benjamin L. Metabolic Engineering, Vol. 14, Issue 6, p. 611-622 https://doi.org/10.1016/j.ymben.2012.07.011	journal	November 2012
Engineering and Two-Stage Evolution of a Lignocellulosic Hydrolysate-Tolerant Saccharomyces cerevisiae Strain for Anaerobic Fermentation of Xylose from AFEX Pretreated Corn Stover Parreiras, Lucas S.; Breuer, Rebecca J.; Avanasi Narasimhan, Ragothaman PLoS ONE, Vol. 9, Issue 9 https://doi.org/10.1371/journal.pone.0107499	journal	September 2014
The Yeast Scaffold Proteins Isu1p and Isu2p Are Required inside Mitochondria for Maturation of Cytosolic Fe/S Proteins Gerber, J.; Neumann, K.; Prohl, C. Molecular and Cellular Biology, Vol. 24, Issue 11 https://doi.org/10.1128/MCB.24.11.4848-4857.2004	journal	May 2004
Directed Evolution Reveals Unexpected Epistatic Interactions That Alter Metabolic Regulation and Enable Anaerobic Xylose Use by Saccharomyces cerevisiae Sato, Trey K.; Tremaine, Mary; Parreiras, Lucas S. PLOS Genetics, Vol. 12, Issue 10 https://doi.org/10.1371/journal.pgen.1006372	journal	October 2016
Mutations in iron-sulfur cluster proteins that improve xylose utilization Froehlich, Allan; Henningsen, Brooks; Covalla, Sean https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9920312 US Patent Document 9,920,312	patent	March 2018

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Title: Recombinant yeast having enhanced xylose fermentation capabilities and methods of use

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