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Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands

Patent ·
OSTI ID:1600190
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Selective chelation of bismuth radionuclide ions from a mixture including actinium radionuclide ions involves exposing a ligand to an aqueous solution that includes bismuth radionuclide ions and actinium radionuclide ions under conditions whereby the bismuth radionuclide ions selectively chelate to the ligand for form cationic complexes of the bismuth radionuclide ions. and separating the cationic complexes of the bismuth radionuclide ions from the actinium radionuclide ions. The ligands have a structure based on a 12-membered cyclen ring and may include pendant functional groups that can be derivatized with biological targeting vectors for targeted alpha therapy.
Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC52-06NA25396
Assignee:
Triad National Security, LLC (Los Alamos, NM)
Patent Number(s):
10,450,336
Application Number:
14/703,253
OSTI ID:
1600190
Country of Publication:
United States
Language:
English

References (7)

Improved in Vivo Stability of Actinium-225 Macrocyclic Complexes journal July 1999
Coordination of bismuth and lead in porphyrins: Towards an in-situ generator for α-radiotherapy? journal October 2009
Models for Amide Ligation in Nonheme Iron Enzymes journal November 1997
The Further Mercurial Adventures of Ip et al journal September 2008
Eight-co-ordination in manganese(II) and iron(II) complexes with a pyrazole-functionalised tetraazamacrocycle journal January 1992
Bismuth(III) complexes with tetra-pyridylmethyl-cyclen journal April 2009
A new general route to the synthesis of polyazamacrocyclic ligands with pendant biomimetic imidazole groups journal January 1989

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38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY