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Title: Structural insight into T cell coinhibition by PD-1H (VISTA)

Authors:
; ; ;  [1]
  1. Yale
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
NIHOTHER
OSTI Identifier:
1599419
Resource Type:
Journal Article
Journal Name:
Proc. Natl. Acad. Sci. USA
Additional Journal Information:
Journal Volume: 117; Journal Issue: (3) ; 01, 2020
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Slater, Benjamin T., Han, Xue, Chen, Lieping, and Xiong, Yong. Structural insight into T cell coinhibition by PD-1H (VISTA). United States: N. p., 2020. Web. doi:10.1073/pnas.1908711117.
Slater, Benjamin T., Han, Xue, Chen, Lieping, & Xiong, Yong. Structural insight into T cell coinhibition by PD-1H (VISTA). United States. doi:10.1073/pnas.1908711117.
Slater, Benjamin T., Han, Xue, Chen, Lieping, and Xiong, Yong. Thu . "Structural insight into T cell coinhibition by PD-1H (VISTA)". United States. doi:10.1073/pnas.1908711117.
@article{osti_1599419,
title = {Structural insight into T cell coinhibition by PD-1H (VISTA)},
author = {Slater, Benjamin T. and Han, Xue and Chen, Lieping and Xiong, Yong},
abstractNote = {},
doi = {10.1073/pnas.1908711117},
journal = {Proc. Natl. Acad. Sci. USA},
number = (3) ; 01, 2020,
volume = 117,
place = {United States},
year = {2020},
month = {2}
}

Works referenced in this record:

Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity
journal, May 2004

  • Chen, Lieping
  • Nature Reviews Immunology, Vol. 4, Issue 5
  • DOI: 10.1038/nri1349

Cell Surface Signaling Molecules in the Control of Immune Responses: A Tide Model
journal, April 2011


Molecular mechanisms of T cell co-stimulation and co-inhibition
journal, March 2013

  • Chen, Lieping; Flies, Dallas B.
  • Nature Reviews Immunology, Vol. 13, Issue 4
  • DOI: 10.1038/nri3405

Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig
journal, November 2003

  • Kremer, Joel M.; Westhovens, Rene; Leon, Marc
  • New England Journal of Medicine, Vol. 349, Issue 20
  • DOI: 10.1056/NEJMoa035075

Costimulation Blockade with Belatacept in Renal Transplantation
journal, August 2005

  • Vincenti, Flavio; Larsen, Christian; Durrbach, Antoine
  • New England Journal of Medicine, Vol. 353, Issue 8
  • DOI: 10.1056/NEJMoa050085

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization
journal, October 2018


VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses
journal, March 2011

  • Wang, Li; Rubinstein, Rotem; Lines, Janet L.
  • The Journal of Experimental Medicine, Vol. 208, Issue 3
  • DOI: 10.1084/jem.20100619

Cutting Edge: A Monoclonal Antibody Specific for the Programmed Death-1 Homolog Prevents Graft-versus-Host Disease in Mouse Models
journal, July 2011

  • Flies, Dallas B.; Wang, Shengdian; Xu, Haiying
  • The Journal of Immunology, Vol. 187, Issue 4
  • DOI: 10.4049/jimmunol.1100660

Coinhibitory receptor PD-1H preferentially suppresses CD4+ T cell–mediated immunity
journal, April 2014

  • Flies, Dallas B.; Han, Xue; Higuchi, Tomoe
  • Journal of Clinical Investigation, Vol. 124, Issue 5
  • DOI: 10.1172/JCI74589

VISTA Regulates the Development of Protective Antitumor Immunity
journal, March 2014


Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity
journal, September 2014

  • Wang, L.; Le Mercier, I.; Putra, J.
  • Proceedings of the National Academy of Sciences, Vol. 111, Issue 41
  • DOI: 10.1073/pnas.1407447111

VISTA Deficiency Accelerates the Development of Fatal Murine Lupus Nephritis
journal, March 2017

  • Ceeraz, Sabrina; Sergent, Petra A.; Plummer, Sean F.
  • Arthritis & Rheumatology, Vol. 69, Issue 4
  • DOI: 10.1002/art.40020

Blocking the VISTA pathway enhances disease progression in (NZB × NZW) F1 female mice
journal, June 2017


A crucial role of the PD-1H coinhibitory receptor in suppressing experimental asthma
journal, May 2017

  • Liu, Huafeng; Li, Xin; Hu, Li
  • Cellular & Molecular Immunology, Vol. 15, Issue 9
  • DOI: 10.1038/cmi.2017.16

Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis
journal, May 2017


VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer
journal, March 2017

  • Gao, Jianjun; Ward, John F.; Pettaway, Curtis A.
  • Nature Medicine, Vol. 23, Issue 5
  • DOI: 10.1038/nm.4308

Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses
journal, May 2015

  • Liu, Jun; Yuan, Ying; Chen, Wenna
  • Proceedings of the National Academy of Sciences, Vol. 112, Issue 21
  • DOI: 10.1073/pnas.1420370112

Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC
journal, April 2012

  • Flajnik, Martin F.; Tlapakova, Tereza; Criscitiello, Michael F.
  • Immunogenetics, Vol. 64, Issue 8
  • DOI: 10.1007/s00251-012-0616-2

The Pfam protein families database in 2019
journal, October 2018

  • El-Gebali, Sara; Mistry, Jaina; Bateman, Alex
  • Nucleic Acids Research, Vol. 47, Issue D1
  • DOI: 10.1093/nar/gky995

The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
journal, February 2008

  • Lin, D. Y. -w.; Tanaka, Y.; Iwasaki, M.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 8
  • DOI: 10.1073/pnas.0712278105

The tyrosine corner: A feature of most greek key β-barrel proteins
journal, November 1994

  • Hemmingsen, Jens M.; Gernert, Kim M.; Richardson, Jane S.
  • Protein Science, Vol. 3, Issue 11
  • DOI: 10.1002/pro.5560031104

The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis
journal, September 2003

  • Clements, C. S.; Reid, H. H.; Beddoe, T.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 19
  • DOI: 10.1073/pnas.1833158100

High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3
journal, November 2018


Dali server update
journal, April 2016

  • Holm, Liisa; Laakso, Laura M.
  • Nucleic Acids Research, Vol. 44, Issue W1
  • DOI: 10.1093/nar/gkw357

TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells
journal, December 2007


The Crystal Structure of the Extracellular Domain of the Inhibitor Receptor Expressed on Myeloid Cells IREM-1
journal, March 2007

  • Márquez, José Antonio; Galfré, Elena; Dupeux, Florine
  • Journal of Molecular Biology, Vol. 367, Issue 2
  • DOI: 10.1016/j.jmb.2007.01.011

Initiation of T cell signaling by CD45 segregation at 'close contacts'
journal, March 2016

  • Chang, Veronica T.; Fernandes, Ricardo A.; Ganzinger, Kristina A.
  • Nature Immunology, Vol. 17, Issue 5
  • DOI: 10.1038/ni.3392

Neuron-specific SALM5 limits inflammation in the CNS via its interaction with HVEM
journal, April 2016


Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy
journal, March 2019


Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53
journal, July 2015


Diversity in the CDR3 Region of VH Is Sufficient for Most Antibody Specificities
journal, July 2000


Structural basis for co-stimulation by the human CTLA-4/B7-2 complex
journal, March 2001

  • Schwartz, Jean-Claude D.; Zhang, Xuewu; Fedorov, Alexander A.
  • Nature, Vol. 410, Issue 6828
  • DOI: 10.1038/35069112

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses
journal, March 2001

  • Stamper, Carin C.; Zhang, Yan; Tobin, James F.
  • Nature, Vol. 410, Issue 6828
  • DOI: 10.1038/35069118

Crystal structure of a soluble CD28-Fab complex
journal, February 2005

  • Evans, Edward J.; Esnouf, Robert M.; Manso-Sancho, Raquel
  • Nature Immunology, Vol. 6, Issue 3
  • DOI: 10.1038/ni1170

Structural Basis of the CD8αβ/MHC Class I Interaction: Focused Recognition Orients CD8β to a T Cell Proximal Position
journal, July 2009

  • Wang, Rui; Natarajan, Kannan; Margulies, David H.
  • The Journal of Immunology, Vol. 183, Issue 4
  • DOI: 10.4049/jimmunol.0901276

The multiple roles of histidine in protein interactions
journal, March 2013

  • Liao, Si-Ming; Du, Qi-Shi; Meng, Jian-Zong
  • Chemistry Central Journal, Vol. 7, Issue 1
  • DOI: 10.1186/1752-153X-7-44

Acidic extracellular microenvironment and cancer
journal, January 2013

  • Kato, Yasumasa; Ozawa, Shigeyuki; Miyamoto, Chihiro
  • Cancer Cell International, Vol. 13, Issue 1
  • DOI: 10.1186/1475-2867-13-89

Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds
journal, December 2007


Small-Molecule Immune Checkpoint Inhibitors Targeting PD-1/PD-L1 and Other Emerging Checkpoint Pathways
journal, August 2018


Deciphering key features in protein structures with the new ENDscript server
journal, April 2014

  • Robert, Xavier; Gouet, Patrice
  • Nucleic Acids Research, Vol. 42, Issue W1
  • DOI: 10.1093/nar/gku316

NMRPipe: A multidimensional spectral processing system based on UNIX pipes
journal, November 1995

  • Delaglio, Frank; Grzesiek, Stephan; Vuister, GeertenW.
  • Journal of Biomolecular NMR, Vol. 6, Issue 3
  • DOI: 10.1007/BF00197809

Likelihood-enhanced fast rotation functions
journal, February 2004

  • Storoni, Laurent C.; McCoy, Airlie J.; Read, Randy J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 3
  • DOI: 10.1107/S0907444903028956

Refinement of Macromolecular Structures by the Maximum-Likelihood Method
journal, May 1997

  • Murshudov, G. N.; Vagin, A. A.; Dodson, E. J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 53, Issue 3
  • DOI: 10.1107/S0907444996012255

The Buccaneer software for automated model building. 1. Tracing protein chains
journal, August 2006


Features and development of Coot
journal, March 2010

  • Emsley, P.; Lohkamp, B.; Scott, W. G.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
  • DOI: 10.1107/S0907444910007493