Bayesian algorithms for recovering structure from single-particle diffraction snapshots of unknown orientation: a comparison

Moths, Brian; Ourmazd, Abbas

doi:10.1107/S0108767311019611

Title: Bayesian algorithms for recovering structure from single-particle diffraction snapshots of unknown orientation: a comparison

Journal Article · Wed Jul 06 00:00:00 EDT 2011 · Acta Crystallographica. Section A, Foundations of Crystallography

DOI:https://doi.org/10.1107/S0108767311019611· OSTI ID:1598203

Moths, Brian ^[1]; Ourmazd, Abbas ^[1]

Univ. of Wisconsin, Milwaukee, WI (United States)

The advent of X-ray free-electron lasers promises the possibility to determine the structure of individual particles such as microcrystallites, viruses and biomolecules from single-shot diffraction snapshots obtained before the particle is destroyed by the intense femtosecond pulse. This program requires the ability to determine the orientation of the particle giving rise to each snapshot at signal levels as low as ~10^-2 photons per pixel. Two apparently different approaches have recently demonstrated this capability. Here we show they represent different implementations of the same fundamental approach, and identify the primary factors limiting their performance.

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Research Organization:: Univ. of Wisconsin, Milwaukee, WI (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0002164

OSTI ID:: 1598203

Journal Information:: Acta Crystallographica. Section A, Foundations of Crystallography, Vol. 67, Issue 5; ISSN 0108-7673

Publisher:: International Union of CrystallographyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 20 works

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References (14)

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Cited By (8)

Conformations of macromolecules and their complexes from heterogeneous datasets Schwander, P.; Fung, R.; Ourmazd, A. Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 369, Issue 1647 https://doi.org/10.1098/rstb.2013.0567	journal	July 2014
High-resolution structure of viruses from random diffraction snapshots Hosseinizadeh, A.; Schwander, P.; Dashti, A. Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 369, Issue 1647 https://doi.org/10.1098/rstb.2013.0326	journal	July 2014
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Single-particle structure determination by X-ray free-electron lasers: Possibilities and challenges Hosseinizadeh, A.; Dashti, A.; Schwander, P. Structural Dynamics, Vol. 2, Issue 4 https://doi.org/10.1063/1.4919740	journal	July 2015
Incorporating particle symmetry into orientation determination in single-particle imaging Tegze, Miklós; Bortel, Gábor Acta Crystallographica Section A Foundations and Advances, Vol. 74, Issue 5 https://doi.org/10.1107/s2053273318008999	journal	August 2018
Conformations of Macromolecules and their Complexes from Heterogeneous Datasets Schwander, P.; Fung, R.; Ourmazd, A. arXiv https://doi.org/10.48550/arxiv.1404.7176	preprint	January 2014
High-resolution structure of viruses from random diffraction snapshots Hosseinizadeh, A.; Schwander, P.; Dashti, A. arXiv https://doi.org/10.48550/arxiv.1404.7180	preprint	January 2014

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