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Title: A refined phase diagram of the tert-butanol–water system and implications on lyophilization process optimization of pharmaceuticals

Abstract

In TBA–water mixtures, using DSC and XRD, the eutectic temperature (-8 °C) and composition (22.5% w/w TBA) were determined.

Authors:
 [1]; ORCiD logo [1];  [2];  [3];  [3]; ORCiD logo [1]
  1. Department of Pharmaceutics, College of Pharmacy; 308 Harvard St. SE; University of Minnesota; Minneapolis; USA
  2. Pfizer Groton Laboratories; Eastern Point Road; Pfizer Inc.; Groton; USA
  3. Pfizer Biotherapeutics, Pfizer Inc.; St. Louis; USA
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
DOE - BASIC ENERGY SCIENCES
OSTI Identifier:
1598024
Resource Type:
Journal Article
Journal Name:
Physical Chemistry Chemical Physics. PCCP (Print)
Additional Journal Information:
Journal Volume: 22; Journal Issue: 3; Journal ID: ISSN 1463-9076
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Bhatnagar, Bakul S., Sonje, Jayesh, Shalaev, Evgenyi, Martin, Susan W. H., Teagarden, Dirk L., and Suryanarayanan, Raj. A refined phase diagram of the tert-butanol–water system and implications on lyophilization process optimization of pharmaceuticals. United States: N. p., 2020. Web. doi:10.1039/C9CP06576H.
Bhatnagar, Bakul S., Sonje, Jayesh, Shalaev, Evgenyi, Martin, Susan W. H., Teagarden, Dirk L., & Suryanarayanan, Raj. A refined phase diagram of the tert-butanol–water system and implications on lyophilization process optimization of pharmaceuticals. United States. doi:10.1039/C9CP06576H.
Bhatnagar, Bakul S., Sonje, Jayesh, Shalaev, Evgenyi, Martin, Susan W. H., Teagarden, Dirk L., and Suryanarayanan, Raj. Wed . "A refined phase diagram of the tert-butanol–water system and implications on lyophilization process optimization of pharmaceuticals". United States. doi:10.1039/C9CP06576H.
@article{osti_1598024,
title = {A refined phase diagram of the tert-butanol–water system and implications on lyophilization process optimization of pharmaceuticals},
author = {Bhatnagar, Bakul S. and Sonje, Jayesh and Shalaev, Evgenyi and Martin, Susan W. H. and Teagarden, Dirk L. and Suryanarayanan, Raj},
abstractNote = {In TBA–water mixtures, using DSC and XRD, the eutectic temperature (-8 °C) and composition (22.5% w/w TBA) were determined.},
doi = {10.1039/C9CP06576H},
journal = {Physical Chemistry Chemical Physics. PCCP (Print)},
issn = {1463-9076},
number = 3,
volume = 22,
place = {United States},
year = {2020},
month = {1}
}

Works referenced in this record:

Practical aspects of lyophilization using non-aqueous co-solvent systems
journal, March 2002


Crystallization of Cephalothin Sodium During Lyophilization from tert-Butyl Alcohol?Water Cosolvent System
journal, January 2005


Use of pure t-butanol as a solvent for freeze-drying: a case study
journal, September 2001


Excess volumes, enthalpies, and Gibbs free energies for mixtures of benzene + p-xylene
journal, December 1979


The Pressure Dependence of the Phase Diagram t-Butanol/Water
journal, July 1985

  • Woznyj, M.; Lüdemann, H. -D.
  • Zeitschrift für Naturforschung A, Vol. 40, Issue 7
  • DOI: 10.1515/zna-1985-0707

Discrepancy between thermodynamic and kinetic stabilities of the tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying
journal, January 2019

  • Ogienko, A. G.; Stoporev, A. S.; Ogienko, A. A.
  • Chemical Communications, Vol. 55, Issue 29
  • DOI: 10.1039/C9CC00397E