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Title: Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy

Authors:
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;  [1]
  1. Central SU
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1598011
Resource Type:
Journal Article
Journal Name:
Mol. Cancer
Additional Journal Information:
Journal Volume: 19; Journal Issue: 2020
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Ren, Daixi, Hua, Yuze, Yu, Boyao, Ye, Xin, He, Ziheng, Li, Chunwei, Wang, Jie, Mo, Yongzhen, Wei, Xiaoxu, Chen, Yunhua, Zhou, Yujuan, Liao, Qianjin, Wang, Hui, Xiang, Bo, Zhou, Ming, Li, Xiaoling, Li, Guiyuan, Li, Yong, Zeng, Zhaoyang, and Xiong, Wei. Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy. United States: N. p., 2020. Web. doi:10.1186/s12943-020-1144-6.
Ren, Daixi, Hua, Yuze, Yu, Boyao, Ye, Xin, He, Ziheng, Li, Chunwei, Wang, Jie, Mo, Yongzhen, Wei, Xiaoxu, Chen, Yunhua, Zhou, Yujuan, Liao, Qianjin, Wang, Hui, Xiang, Bo, Zhou, Ming, Li, Xiaoling, Li, Guiyuan, Li, Yong, Zeng, Zhaoyang, & Xiong, Wei. Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy. United States. doi:10.1186/s12943-020-1144-6.
Ren, Daixi, Hua, Yuze, Yu, Boyao, Ye, Xin, He, Ziheng, Li, Chunwei, Wang, Jie, Mo, Yongzhen, Wei, Xiaoxu, Chen, Yunhua, Zhou, Yujuan, Liao, Qianjin, Wang, Hui, Xiang, Bo, Zhou, Ming, Li, Xiaoling, Li, Guiyuan, Li, Yong, Zeng, Zhaoyang, and Xiong, Wei. Mon . "Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy". United States. doi:10.1186/s12943-020-1144-6.
@article{osti_1598011,
title = {Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy},
author = {Ren, Daixi and Hua, Yuze and Yu, Boyao and Ye, Xin and He, Ziheng and Li, Chunwei and Wang, Jie and Mo, Yongzhen and Wei, Xiaoxu and Chen, Yunhua and Zhou, Yujuan and Liao, Qianjin and Wang, Hui and Xiang, Bo and Zhou, Ming and Li, Xiaoling and Li, Guiyuan and Li, Yong and Zeng, Zhaoyang and Xiong, Wei},
abstractNote = {},
doi = {10.1186/s12943-020-1144-6},
journal = {Mol. Cancer},
number = 2020,
volume = 19,
place = {United States},
year = {2020},
month = {2}
}

Works referenced in this record:

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization
journal, October 2018


Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
journal, June 2002

  • Dong, Haidong; Strome, Scott E.; Salomao, Diva R.
  • Nature Medicine, Vol. 8, Issue 8
  • DOI: 10.1038/nm730

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
journal, December 1999

  • Dong, Haidong; Zhu, Gefeng; Tamada, Koji
  • Nature Medicine, Vol. 5, Issue 12
  • DOI: 10.1038/70932

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy
journal, April 2015


Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
journal, June 2012

  • Topalian, Suzanne L.; Hodi, F. Stephen; Brahmer, Julie R.
  • New England Journal of Medicine, Vol. 366, Issue 26
  • DOI: 10.1056/NEJMoa1200690

FDA Approval Summary: Pembrolizumab for the Treatment of Microsatellite Instability-High Solid Tumors
journal, February 2019


Microsatellite Instability as a Biomarker for PD-1 Blockade
journal, February 2016


Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
journal, March 2015

  • Rizvi, Naiyer A.; Hellmann, Matthew D.; Snyder, Alexandra
  • Science, Vol. 348, Issue 6230
  • DOI: 10.1126/science.aaa1348

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
journal, February 2018

  • Tauriello, Daniele V. F.; Palomo-Ponce, Sergio; Stork, Diana
  • Nature, Vol. 554, Issue 7693
  • DOI: 10.1038/nature25492

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
journal, February 2018

  • Mariathasan, Sanjeev; Turley, Shannon J.; Nickles, Dorothee
  • Nature, Vol. 554, Issue 7693
  • DOI: 10.1038/nature25501

Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade
journal, September 2017


Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
journal, November 2017

  • Routy, Bertrand; Le Chatelier, Emmanuelle; Derosa, Lisa
  • Science, Vol. 359, Issue 6371
  • DOI: 10.1126/science.aan3706

The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut
journal, April 2012