skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Linking phenylpropanoid metabolism, lignin deposition, and plant growth inhibition

Abstract

Lignin, a polymer found in the plant secondary cell wall, is a major contributor to biomass’ recalcitrance toward saccharification. Because of this negative impact toward the value of lignocellulosic crops, there is a special interest in modifying the content and composition of this important plant biopolymer. For many years this endeavor has been hindered by the plant growth inhibition that is often associated with manipulations to phenylpropanoid metabolism. Although the actual mechanism by which dwarfism arises remains unknown, recent advances in tissue-specific lignin complementation and better understanding of phenylpropanoid transcriptional regulation has made it possible to disentangle lignin modification from perturbations in plant development.

Authors:
ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]
  1. Purdue Univ., West Lafayette, IN (United States). Dept. of Biochemistry; Purdue Univ., West Lafayette, IN (United States). Purdue Center for Plant Biology
Publication Date:
Research Org.:
Purdue Univ., West Lafayette, IN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1597904
Grant/Contract Number:  
FG02-07ER15905
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Current Opinion in Biotechnology
Additional Journal Information:
Journal Volume: 56; Journal Issue: C; Journal ID: ISSN 0958-1669
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
09 BIOMASS FUELS

Citation Formats

Muro-Villanueva, Fabiola, Mao, Xiangying, and Chapple, Clint. Linking phenylpropanoid metabolism, lignin deposition, and plant growth inhibition. United States: N. p., 2019. Web. doi:10.1016/j.copbio.2018.12.008.
Muro-Villanueva, Fabiola, Mao, Xiangying, & Chapple, Clint. Linking phenylpropanoid metabolism, lignin deposition, and plant growth inhibition. United States. https://doi.org/10.1016/j.copbio.2018.12.008
Muro-Villanueva, Fabiola, Mao, Xiangying, and Chapple, Clint. 2019. "Linking phenylpropanoid metabolism, lignin deposition, and plant growth inhibition". United States. https://doi.org/10.1016/j.copbio.2018.12.008. https://www.osti.gov/servlets/purl/1597904.
@article{osti_1597904,
title = {Linking phenylpropanoid metabolism, lignin deposition, and plant growth inhibition},
author = {Muro-Villanueva, Fabiola and Mao, Xiangying and Chapple, Clint},
abstractNote = {Lignin, a polymer found in the plant secondary cell wall, is a major contributor to biomass’ recalcitrance toward saccharification. Because of this negative impact toward the value of lignocellulosic crops, there is a special interest in modifying the content and composition of this important plant biopolymer. For many years this endeavor has been hindered by the plant growth inhibition that is often associated with manipulations to phenylpropanoid metabolism. Although the actual mechanism by which dwarfism arises remains unknown, recent advances in tissue-specific lignin complementation and better understanding of phenylpropanoid transcriptional regulation has made it possible to disentangle lignin modification from perturbations in plant development.},
doi = {10.1016/j.copbio.2018.12.008},
url = {https://www.osti.gov/biblio/1597904}, journal = {Current Opinion in Biotechnology},
issn = {0958-1669},
number = C,
volume = 56,
place = {United States},
year = {2019},
month = {4}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Citation Metrics:
Cited by: 9 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Lignin plays a negative role in the biochemical process for producing lignocellulosic biofuels
journal, June 2014


Designer lignins: harnessing the plasticity of lignification
journal, February 2016


The influence of lignification on the development of vascular tissue inVigna radiata L.
journal, February 1985


Genetic manipulation of lignocellulosic biomass for bioenergy
journal, December 2015


Can genetic engineering of lignin deposition be accomplished without an unacceptable yield penalty?
journal, April 2013


The Arabidopsis REF8 gene encodes the 3-hydroxylase of phenylpropanoid metabolism
journal, April 2002


Silencing of Hydroxycinnamoyl-Coenzyme A Shikimate/Quinate Hydroxycinnamoyltransferase Affects Phenylpropanoid Biosynthesis
journal, May 2004


Reduced wood stiffness and strength, and altered stem form, in young antisense 4CL transgenic poplars with reduced lignin contents
journal, December 2010


Targeted down-regulation of cytochrome P450 enzymes for forage quality improvement in alfalfa (Medicago sativa L.)
journal, November 2005


Selective lignin downregulation leads to constitutive defense response expression in alfalfa (Medicago sativa L.)
journal, January 2011


Down-regulation of Cinnamoyl-CoA Reductase induces significant changes of lignin profiles in transgenic tobacco plants
journal, January 1998


Caffeoyl Shikimate Esterase (CSE) Is an Enzyme in the Lignin Biosynthetic Pathway in Arabidopsis
journal, August 2013


An essential role of caffeoyl shikimate esterase in monolignol biosynthesis in Medicago truncatula
journal, June 2016


Genetic manipulation of lignin reduces recalcitrance and improves ethanol production from switchgrass
journal, February 2011


Red Xylem and Higher Lignin Extractability by Down-Regulating a Cinnamyl Alcohol Dehydrogenase in Poplar
journal, December 1996


Cloning and characterization of irregular xylem4 (irx4):a severely lignin-deficient mutant of Arabidopsis
journal, April 2001


Changes in secondary metabolism and deposition of an unusual lignin in the ref8 mutant of Arabidopsis
journal, April 2002


Semidominant Mutations in Reduced Epidermal Fluorescence 4 Reduce Phenylpropanoid Content in Arabidopsis
journal, April 2008


A Battery of Transcription Factors Involved in the Regulation of Secondary Cell Wall Biosynthesis in Arabidopsis
journal, October 2008


Arabidopsis irregular xylem8 and irregular xylem9 : Implications for the Complexity of Glucuronoxylan Biosynthesis
journal, February 2007


Comparison of five xylan synthesis mutants reveals new insight into the mechanisms of xylan synthesis
journal, December 2007


Engineering secondary cell wall deposition in plants
journal, November 2012


Defining the Diverse Cell Populations Contributing to Lignification in Arabidopsis Stems
journal, April 2017


Trans-Cinnamic acid as an Anti-Auxin
journal, October 1951


Study of cis-cinnamic acid in Arabidopsis thaliana
journal, October 2005


Auxin Polar Transport Is Essential for the Establishment of Bilateral Symmetry during Early Plant Embryogenesis
journal, June 1993


cis-Cinnamic Acid Is a Novel, Natural Auxin Efflux Inhibitor That Promotes Lateral Root Formation
journal, November 2016


The flavonoid biosynthetic pathway in plants: Function and evolution
journal, February 1994


Flavonoid Accumulation in Arabidopsis Repressed in Lignin Synthesis Affects Auxin Transport and Plant Growth
journal, January 2007


Salicylic acid mediates the reduced growth of lignin down-regulated plants
journal, November 2011


Disruption of Mediator rescues the stunted growth of a lignin-deficient Arabidopsis mutant
journal, March 2014


Cell division promoting activity of naturally occurring dehydrodiconiferyl glucosides: do cell wall components control cell division?
journal, February 1987


Activity and Accumulation of Cell Division-Promoting Phenolics in Tobacco Tissue Cultures
journal, September 1991


Scopoletin 8-Hydroxylase-Mediated Fraxetin Production Is Crucial for Iron Mobilization
journal, March 2018


Biosynthesis of redox-active metabolites in response to iron deficiency in plants
journal, March 2018


Out Of The Quagmire Of Plant Defense Hypotheses
journal, March 2003


Wall-associated Kinase WAK1 Interacts with Cell Wall Pectins in a Calcium-induced Conformation
journal, February 2005


A domain swap approach reveals a role of the plant wall-associated kinase 1 (WAK1) as a receptor of oligogalacturonides
journal, May 2010


A Receptor-like Kinase Mediates the Response of Arabidopsis Cells to the Inhibition of Cellulose Synthesis
journal, June 2007


Elicitors and defense gene induction in plants with altered lignin compositions
journal, June 2018


Lignin monomer composition is determined by the expression of a cytochrome P450-dependent monooxygenase in Arabidopsis
journal, June 1998


REF4 and RFR1, Subunits of the Transcriptional Coregulatory Complex Mediator, Are Required for Phenylpropanoid Homeostasis in Arabidopsis
journal, December 2011


Mediator Complex Subunits MED2, MED5, MED16, and MED23 Genetically Interact in the Regulation of Phenylpropanoid Biosynthesis
journal, December 2017


Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor MONGOOSE1
journal, December 2015


Works referencing / citing this record:

Genome-wide characterization of the laccase gene family in Setaria viridis reveals members potentially involved in lignification
journal, January 2020


Expression of Eucalyptus globulus LACCASE48 Restores Lignin Content of Arabidopsis thaliana lac17 Mutant
journal, November 2019