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Title: CPR5 modulates salicylic acid and the unfolded protein response to manage tradeoffs between plant growth and stress responses

Abstract

We report that completion of a plant's life cycle depends on successful prioritization of signaling favoring either growth or defense. Although hormones are pivotal regulators of growth-defense tradeoffs, the underlying signaling mechanisms remain obscure. The unfolded protein response (UPR) is essential for physiological growth as well as management of endoplasmic reticulum (ER) stress in unfavorable growth conditions. The plant UPR transducers are the kinase and ribonuclease IRE1 and the transcription factors bZIP28 and bZIP60. We analyzed management of the tradeoff between growth and ER stress defense by the stress response hormone salicylic acid (SA) and the UPR, which is modulated by SA via unknown mechanisms. We show that the plant growth and stress regulator CPR5, which represses accumulation of SA, favors growth in physiological conditions through inhibition of the SA-dependent IRE1-bZIP60 arm that antagonizes organ growth; CPR5 also favors growth in stress conditions through repression of ER stress-induced bZIP28/IRE1-bZIP60 arms. By demonstrating a physical interaction of CPR5 with bZIP60 and bZIP28, we provide mechanistic insights into CPR5-mediated modulation of UPR signaling. In conclusion, these findings define a critical surveillance strategy for plant growth-ER stress defense tradeoffs based on CPR5 and SA-modulated UPR signaling, whereby CPR5 acts as a positive modulatormore » of growth in physiological conditions and in stress by antagonizing SA-dependent growth inhibition through UPR modulation.« less

Authors:
 [1];  [2];  [3];  [2]
  1. Michigan State Univ., East Lansing, MI (United States); China Agricultural Univ., Beijing (China)
  2. Michigan State Univ., East Lansing, MI (United States)
  3. China Agricultural Univ., Beijing (China)
Publication Date:
Research Org.:
Michigan State Univ., East Lansing, MI (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22). Chemical Sciences, Geosciences & Biosciences Division; National Institutes of Health (NIH)
OSTI Identifier:
1596279
Alternate Identifier(s):
OSTI ID: 1401716
Grant/Contract Number:  
FG02-91ER20021; GM101038
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
The Plant Journal
Additional Journal Information:
Journal Volume: 89; Journal Issue: 3; Journal ID: ISSN 0960-7412
Publisher:
Society for Experimental Biology
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CPR5; ER stress response; plant defense tradeoffs; salicylic acid; unfolded protein response; Arabidopsis thaliana

Citation Formats

Meng, Zhe, Ruberti, Cristina, Gong, Zhizhong, and Brandizzi, Federica. CPR5 modulates salicylic acid and the unfolded protein response to manage tradeoffs between plant growth and stress responses. United States: N. p., 2016. Web. doi:10.1111/tpj.13397.
Meng, Zhe, Ruberti, Cristina, Gong, Zhizhong, & Brandizzi, Federica. CPR5 modulates salicylic acid and the unfolded protein response to manage tradeoffs between plant growth and stress responses. United States. doi:10.1111/tpj.13397.
Meng, Zhe, Ruberti, Cristina, Gong, Zhizhong, and Brandizzi, Federica. Sun . "CPR5 modulates salicylic acid and the unfolded protein response to manage tradeoffs between plant growth and stress responses". United States. doi:10.1111/tpj.13397. https://www.osti.gov/servlets/purl/1596279.
@article{osti_1596279,
title = {CPR5 modulates salicylic acid and the unfolded protein response to manage tradeoffs between plant growth and stress responses},
author = {Meng, Zhe and Ruberti, Cristina and Gong, Zhizhong and Brandizzi, Federica},
abstractNote = {We report that completion of a plant's life cycle depends on successful prioritization of signaling favoring either growth or defense. Although hormones are pivotal regulators of growth-defense tradeoffs, the underlying signaling mechanisms remain obscure. The unfolded protein response (UPR) is essential for physiological growth as well as management of endoplasmic reticulum (ER) stress in unfavorable growth conditions. The plant UPR transducers are the kinase and ribonuclease IRE1 and the transcription factors bZIP28 and bZIP60. We analyzed management of the tradeoff between growth and ER stress defense by the stress response hormone salicylic acid (SA) and the UPR, which is modulated by SA via unknown mechanisms. We show that the plant growth and stress regulator CPR5, which represses accumulation of SA, favors growth in physiological conditions through inhibition of the SA-dependent IRE1-bZIP60 arm that antagonizes organ growth; CPR5 also favors growth in stress conditions through repression of ER stress-induced bZIP28/IRE1-bZIP60 arms. By demonstrating a physical interaction of CPR5 with bZIP60 and bZIP28, we provide mechanistic insights into CPR5-mediated modulation of UPR signaling. In conclusion, these findings define a critical surveillance strategy for plant growth-ER stress defense tradeoffs based on CPR5 and SA-modulated UPR signaling, whereby CPR5 acts as a positive modulator of growth in physiological conditions and in stress by antagonizing SA-dependent growth inhibition through UPR modulation.},
doi = {10.1111/tpj.13397},
journal = {The Plant Journal},
issn = {0960-7412},
number = 3,
volume = 89,
place = {United States},
year = {2016},
month = {10}
}

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Cited by: 8 works
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    Works referencing / citing this record:

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