skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics

Authors:
; ; ; ; ;  [1]
  1. UIUC
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1593441
Resource Type:
Journal Article
Journal Name:
Proc. Natl. Acad. Sci. USA
Additional Journal Information:
Journal Volume: 116; Journal Issue: (35) ; 08, 2019
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Bothwell, Ian R., Cogan, Dillon P., Kim, Terry, Reinhardt, Christopher J., van der Donk, Wilfred A., and Nair, Satish K. Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics. United States: N. p., 2020. Web. doi:10.1073/pnas.1905240116.
Bothwell, Ian R., Cogan, Dillon P., Kim, Terry, Reinhardt, Christopher J., van der Donk, Wilfred A., & Nair, Satish K. Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics. United States. doi:10.1073/pnas.1905240116.
Bothwell, Ian R., Cogan, Dillon P., Kim, Terry, Reinhardt, Christopher J., van der Donk, Wilfred A., and Nair, Satish K. Wed . "Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics". United States. doi:10.1073/pnas.1905240116.
@article{osti_1593441,
title = {Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics},
author = {Bothwell, Ian R. and Cogan, Dillon P. and Kim, Terry and Reinhardt, Christopher J. and van der Donk, Wilfred A. and Nair, Satish K.},
abstractNote = {},
doi = {10.1073/pnas.1905240116},
journal = {Proc. Natl. Acad. Sci. USA},
number = (35) ; 08, 2019,
volume = 116,
place = {United States},
year = {2020},
month = {1}
}

Works referenced in this record:

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
journal, January 2013

  • Arnison, Paul G.; Bibb, Mervyn J.; Bierbaum, Gabriele
  • Nat. Prod. Rep., Vol. 30, Issue 1
  • DOI: 10.1039/c2np20085f

Follow the leader: the use of leader peptides to guide natural product biosynthesis
journal, December 2009

  • Oman, Trent J.; van der Donk, Wilfred A.
  • Nature Chemical Biology, Vol. 6, Issue 1
  • DOI: 10.1038/nchembio.286

Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB
journal, October 2014


In vitro activity of the nisin dehydratase NisB
journal, April 2013

  • Garg, N.; Salazar-Ocampo, L. M. A.; van der Donk, W. A.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 18
  • DOI: 10.1073/pnas.1222488110

Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis
journal, March 2016


A prevalent peptide-binding domain guides ribosomal natural product biosynthesis
journal, July 2015

  • Burkhart, Brandon J.; Hudson, Graham A.; Dunbar, Kyle L.
  • Nature Chemical Biology, Vol. 11, Issue 8
  • DOI: 10.1038/nchembio.1856

In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin
journal, December 2015

  • Hudson, Graham A.; Zhang, Zhengan; Tietz, Jonathan I.
  • Journal of the American Chemical Society, Vol. 137, Issue 51
  • DOI: 10.1021/jacs.5b10194

A new genome-mining tool redefines the lasso peptide biosynthetic landscape
journal, February 2017

  • Tietz, Jonathan I.; Schwalen, Christopher J.; Patel, Parth S.
  • Nature Chemical Biology, Vol. 13, Issue 5
  • DOI: 10.1038/nchembio.2319

Phenylalanyl-tRNA synthetase editing defects result in efficient mistranslation of phenylalanine codons as tyrosine
journal, September 2007

  • Ling, J.; Yadavalli, S. S.; Ibba, M.
  • RNA, Vol. 13, Issue 11, p. 1881-1886
  • DOI: 10.1261/rna.684107

Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS
journal, August 2014

  • Zhang, Q.; Ortega, M.; Shi, Y.
  • Proceedings of the National Academy of Sciences, Vol. 111, Issue 33
  • DOI: 10.1073/pnas.1406418111

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes
journal, January 2017


Requirements of the Engineered Leader Peptide of Nisin for Inducing Modification, Export, and Cleavage
journal, November 2010

  • Plat, Annechien; Kluskens, Leon D.; Kuipers, Anneke
  • Applied and Environmental Microbiology, Vol. 77, Issue 2
  • DOI: 10.1128/AEM.01503-10

Part-of-the-sites binding and reactivity in the homooligomeric enzymes – facts and artifacts
journal, March 2018

  • Wielgus-Kutrowska, Beata; Grycuk, Tomasz; Bzowska, Agnieszka
  • Archives of Biochemistry and Biophysics, Vol. 642
  • DOI: 10.1016/j.abb.2018.01.011

Ribonucleic acid composition of bacteria as a function of growth rate
journal, July 1966


Co-variation of tRNA Abundance and Codon Usage inEscherichia coliat Different Growth Rates
journal, August 1996

  • Dong, Hengjiang; Nilsson, Lars; Kurland, Charles G.
  • Journal of Molecular Biology, Vol. 260, Issue 5
  • DOI: 10.1006/jmbi.1996.0428

FEM: feature-enhanced map
journal, February 2015

  • Afonine, Pavel V.; Moriarty, Nigel W.; Mustyakimov, Marat
  • Acta Crystallographica Section D Biological Crystallography, Vol. 71, Issue 3
  • DOI: 10.1107/S1399004714028132