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Title: Microscopy Techniques for Investigating the Control of Organic Constituents on Biomineralization

Abstract

In this paper we address recent advances in the application of microscopy techniques to characterize crystallization processes as they relate to biomineralization and bio-inspired materials synthesis. In particular, we focus on studies aimed at revealing the role that organic macromolecules and functionalized surfaces have in modulating the mechanisms of nucleation and growth. In the nucleation studies, we explore the use of methods such asin situ transmission electron microscopy (TEM),atomic force microscopy (AFM), and cryogenic electron microscopy (cryoEM)to delineate formation pathways, phase stabilization, and the competing effects of free energy and kinetic barriers. In the growth studies, an emphasis is placed on understanding the interactions of macromolecular constituents with growing crystals and how to characterize the internal structures of the resulting composite crystals using techniques such as electron tomography, atom probe tomography (APT), and vibrational spectromicroscopy. Examples are drawn from both biological and bio-inspired synthetic systems.

Authors:
 [1]; ORCiD logo [2];  [1];  [2];  [1]
  1. Cornell University
  2. BATTELLE (PACIFIC NW LAB)
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1581968
Report Number(s):
PNNL-SA-108196
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
MRS Bulletin
Additional Journal Information:
Journal Volume: 40; Journal Issue: 6
Country of Publication:
United States
Language:
English

Citation Formats

Hendley, Coit T., Tao, Jinhui, Kunitake, Jennie A., De Yoreo, James J., and Estroff, Lara A. Microscopy Techniques for Investigating the Control of Organic Constituents on Biomineralization. United States: N. p., 2015. Web. doi:10.1557/mrs.2015.98.
Hendley, Coit T., Tao, Jinhui, Kunitake, Jennie A., De Yoreo, James J., & Estroff, Lara A. Microscopy Techniques for Investigating the Control of Organic Constituents on Biomineralization. United States. doi:10.1557/mrs.2015.98.
Hendley, Coit T., Tao, Jinhui, Kunitake, Jennie A., De Yoreo, James J., and Estroff, Lara A. Sat . "Microscopy Techniques for Investigating the Control of Organic Constituents on Biomineralization". United States. doi:10.1557/mrs.2015.98.
@article{osti_1581968,
title = {Microscopy Techniques for Investigating the Control of Organic Constituents on Biomineralization},
author = {Hendley, Coit T. and Tao, Jinhui and Kunitake, Jennie A. and De Yoreo, James J. and Estroff, Lara A.},
abstractNote = {In this paper we address recent advances in the application of microscopy techniques to characterize crystallization processes as they relate to biomineralization and bio-inspired materials synthesis. In particular, we focus on studies aimed at revealing the role that organic macromolecules and functionalized surfaces have in modulating the mechanisms of nucleation and growth. In the nucleation studies, we explore the use of methods such asin situ transmission electron microscopy (TEM),atomic force microscopy (AFM), and cryogenic electron microscopy (cryoEM)to delineate formation pathways, phase stabilization, and the competing effects of free energy and kinetic barriers. In the growth studies, an emphasis is placed on understanding the interactions of macromolecular constituents with growing crystals and how to characterize the internal structures of the resulting composite crystals using techniques such as electron tomography, atom probe tomography (APT), and vibrational spectromicroscopy. Examples are drawn from both biological and bio-inspired synthetic systems.},
doi = {10.1557/mrs.2015.98},
journal = {MRS Bulletin},
number = 6,
volume = 40,
place = {United States},
year = {2015},
month = {6}
}

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