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Title: Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15


Citation Formats

Faust, Tyler B., Yoon, Hojong, Nowak, Radosław P., Donovan, Katherine A., Li, Zhengnian, Cai, Quan, Eleuteri, Nicholas A., Zhang, Tinghu, Gray, Nathanael S., and Fischer, Eric S. Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. United States: N. p., 2019. Web. doi:10.1038/s41589-019-0378-3.
Faust, Tyler B., Yoon, Hojong, Nowak, Radosław P., Donovan, Katherine A., Li, Zhengnian, Cai, Quan, Eleuteri, Nicholas A., Zhang, Tinghu, Gray, Nathanael S., & Fischer, Eric S. Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. United States. doi:10.1038/s41589-019-0378-3.
Faust, Tyler B., Yoon, Hojong, Nowak, Radosław P., Donovan, Katherine A., Li, Zhengnian, Cai, Quan, Eleuteri, Nicholas A., Zhang, Tinghu, Gray, Nathanael S., and Fischer, Eric S. Mon . "Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15". United States. doi:10.1038/s41589-019-0378-3.
@article{osti_1581823,
title = {Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15},
author = {Faust, Tyler B. and Yoon, Hojong and Nowak, Radosław P. and Donovan, Katherine A. and Li, Zhengnian and Cai, Quan and Eleuteri, Nicholas A. and Zhang, Tinghu and Gray, Nathanael S. and Fischer, Eric S.},
abstractNote = {},
doi = {10.1038/s41589-019-0378-3},
journal = {Nature Chemical Biology},
issn = {1552-4450},
number = 1,
volume = 16,
place = {United States},
year = {2019},
month = {11}
}

Works referenced in this record:

Selective degradation of splicing factor CAPERα by anticancer sulfonamides
journal, April 2017

  • Uehara, Taisuke; Minoshima, Yukinori; Sagane, Koji
  • Nature Chemical Biology, Vol. 13, Issue 6
  • DOI: 10.1038/nchembio.2363

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
journal, July 2014

  • Fischer, Eric S.; Böhm, Kerstin; Lydeard, John R.
  • Nature, Vol. 512, Issue 7512
  • DOI: 10.1038/nature13527

Plasticity in binding confers selectivity in ligand-induced protein degradation
journal, June 2018

  • Nowak, Radosław P.; DeAngelo, Stephen L.; Buckley, Dennis
  • Nature Chemical Biology, Vol. 14, Issue 7
  • DOI: 10.1038/s41589-018-0055-y

Overview of the CCP 4 suite and current developments
journal, March 2011

  • Winn, Martyn D.; Ballard, Charles C.; Cowtan, Kevin D.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4
  • DOI: 10.1107/S0907444910045749

Structural insights into DDA1 function as a core component of the CRL4-DDB1 ubiquitin ligase
journal, December 2018


Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase
journal, February 2016

  • Petzold, Georg; Fischer, Eric S.; Thomä, Nicolas H.
  • Nature, Vol. 532, Issue 7597
  • DOI: 10.1038/nature16979

Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor
journal, October 2010


Towards automated crystallographic structure refinement with phenix.refine
journal, March 2012

  • Afonine, Pavel V.; Grosse-Kunstleve, Ralf W.; Echols, Nathaniel
  • Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 4
  • DOI: 10.1107/S0907444912001308

Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia
journal, March 2019


Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome
journal, August 2018


PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

Identification of a Primary Target of Thalidomide Teratogenicity
journal, March 2010


Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
journal, November 2013


SPLINTS: small-molecule protein ligand interface stabilizers
journal, April 2016

  • Fischer, Eric S.; Park, Eunyoung; Eck, Michael J.
  • Current Opinion in Structural Biology, Vol. 37
  • DOI: 10.1016/j.sbi.2016.01.004

Mechanism of auxin perception by the TIR1 ubiquitin ligase
journal, April 2007

  • Tan, Xu; Calderon-Villalobos, Luz Irina A.; Sharon, Michal
  • Nature, Vol. 446, Issue 7136
  • DOI: 10.1038/nature05731

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN
journal, November 2018

  • Sievers, Quinlan L.; Petzold, Georg; Bunker, Richard D.
  • Science, Vol. 362, Issue 6414
  • DOI: 10.1126/science.aat0572

CTFFIND4: Fast and accurate defocus estimation from electron micrographs
journal, November 2015


E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo
journal, January 2001


Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
journal, March 2017


Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs
journal, August 2014

  • Chamberlain, Philip P.; Lopez-Girona, Antonia; Miller, Karen
  • Nature Structural & Molecular Biology, Vol. 21, Issue 9
  • DOI: 10.1038/nsmb.2874

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
journal, November 2013


Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions
journal, January 2015

  • Brown, Alan; Long, Fei; Nicholls, Robert A.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 71, Issue 1
  • DOI: 10.1107/S1399004714021683

ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures
journal, July 2005

  • Landau, M.; Mayrose, I.; Rosenberg, Y.
  • Nucleic Acids Research, Vol. 33, Issue Web Server
  • DOI: 10.1093/nar/gki370

New tools for automated high-resolution cryo-EM structure determination in RELION-3
journal, November 2018

  • Zivanov, Jasenko; Nakane, Takanori; Forsberg, Björn O.
  • eLife, Vol. 7
  • DOI: 10.7554/eLife.42166

An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases
journal, March 2009

  • Olma, M. H.; Roy, M.; Le Bihan, T.
  • Journal of Cell Science, Vol. 122, Issue 7
  • DOI: 10.1242/jcs.043539

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation
journal, November 2011


A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase
journal, June 2016

  • Matyskiela, Mary E.; Lu, Gang; Ito, Takumi
  • Nature, Vol. 535, Issue 7611
  • DOI: 10.1038/nature18611

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
journal, February 2017

  • Zheng, Shawn Q.; Palovcak, Eugene; Armache, Jean-Paul
  • Nature Methods, Vol. 14, Issue 4
  • DOI: 10.1038/nmeth.4193

Waste disposal—An attractive strategy for cancer therapy
journal, March 2017


Structural assembly of cullin-RING ubiquitin ligase complexes
journal, December 2010

  • Zimmerman, Erik S.; Schulman, Brenda A.; Zheng, Ning
  • Current Opinion in Structural Biology, Vol. 20, Issue 6
  • DOI: 10.1016/j.sbi.2010.08.010

A set of baculovirus transfer vectors for screening of affinity tags and parallel expression strategies
journal, February 2009

  • Abdulrahman, Wassim; Uhring, Muriel; Kolb-Cheynel, Isabelle
  • Analytical Biochemistry, Vol. 385, Issue 2
  • DOI: 10.1016/j.ab.2008.10.044

Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome
journal, March 2016

  • Cavadini, Simone; Fischer, Eric S.; Bunker, Richard D.
  • Nature, Vol. 531, Issue 7596
  • DOI: 10.1038/nature17416

XDS
journal, January 2010

  • Kabsch, Wolfgang
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2
  • DOI: 10.1107/S0907444909047337

Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206