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Title: Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids

Abstract

A flexible and wearable microsensor array is described for simultaneous multiplexed monitoring of heavy metals in human body fluids. Zn, Cd, Pb, Cu, and Hg ions are chosen as target analytes for detection via electrochemical square wave anodic stripping voltammetry (SWASV) on Au and Bi microelectrodes. The oxidation peaks of these metals are calibrated and compensated by incorporating a skin temperature sensor. High selectivity, repeatability, and flexibility of the sensor arrays are presented. Human sweat and urine samples are collected for heavy metal analysis, and measured results from the microsensors are validated through inductively coupled plasma mass spectrometry (ICP-MS). Real-time on-body evaluation of heavy metal (e.g., zinc and copper) levels in sweat of human subjects by cycling is performed to examine the change in concentrations with time. Finally, this platform is anticipated to provide insightful information about an individual's health state such as heavy metal exposure and aid the related clinical investigations.

Authors:
 [1];  [1];  [2];  [2];  [1];  [1];  [1];  [1];  [1];  [2];  [1];  [2];  [1];  [3]
  1. Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
  2. Univ. of California, Berkeley, CA (United States)
  3. Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)s
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
National Science Foundation (NSF)
OSTI Identifier:
1580045
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
ACS Sensors
Additional Journal Information:
Journal Volume: 1; Journal Issue: 7; Journal ID: ISSN 2379-3694
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; flexible electronics; wearable biosensors; heavy metals monitoring; sweat; multiplexed sensing; temperature compensation

Citation Formats

Gao, Wei, Nyein, Hnin Y. Y., Shahpar, Ziba, Fahad, Hossain M., Chen, Kevin, Emaminejad, Sam, Gao, Yuji, Tai, Li-Chia, Ota, Hiroki, Wu, Eric, Bullock, James, Zeng, Yuping, Lien, Der-Hsien, and Javey, Ali. Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids. United States: N. p., 2016. Web. doi:10.1021/acssensors.6b00287.
Gao, Wei, Nyein, Hnin Y. Y., Shahpar, Ziba, Fahad, Hossain M., Chen, Kevin, Emaminejad, Sam, Gao, Yuji, Tai, Li-Chia, Ota, Hiroki, Wu, Eric, Bullock, James, Zeng, Yuping, Lien, Der-Hsien, & Javey, Ali. Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids. United States. https://doi.org/10.1021/acssensors.6b00287
Gao, Wei, Nyein, Hnin Y. Y., Shahpar, Ziba, Fahad, Hossain M., Chen, Kevin, Emaminejad, Sam, Gao, Yuji, Tai, Li-Chia, Ota, Hiroki, Wu, Eric, Bullock, James, Zeng, Yuping, Lien, Der-Hsien, and Javey, Ali. Mon . "Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids". United States. https://doi.org/10.1021/acssensors.6b00287. https://www.osti.gov/servlets/purl/1580045.
@article{osti_1580045,
title = {Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids},
author = {Gao, Wei and Nyein, Hnin Y. Y. and Shahpar, Ziba and Fahad, Hossain M. and Chen, Kevin and Emaminejad, Sam and Gao, Yuji and Tai, Li-Chia and Ota, Hiroki and Wu, Eric and Bullock, James and Zeng, Yuping and Lien, Der-Hsien and Javey, Ali},
abstractNote = {A flexible and wearable microsensor array is described for simultaneous multiplexed monitoring of heavy metals in human body fluids. Zn, Cd, Pb, Cu, and Hg ions are chosen as target analytes for detection via electrochemical square wave anodic stripping voltammetry (SWASV) on Au and Bi microelectrodes. The oxidation peaks of these metals are calibrated and compensated by incorporating a skin temperature sensor. High selectivity, repeatability, and flexibility of the sensor arrays are presented. Human sweat and urine samples are collected for heavy metal analysis, and measured results from the microsensors are validated through inductively coupled plasma mass spectrometry (ICP-MS). Real-time on-body evaluation of heavy metal (e.g., zinc and copper) levels in sweat of human subjects by cycling is performed to examine the change in concentrations with time. Finally, this platform is anticipated to provide insightful information about an individual's health state such as heavy metal exposure and aid the related clinical investigations.},
doi = {10.1021/acssensors.6b00287},
url = {https://www.osti.gov/biblio/1580045}, journal = {ACS Sensors},
issn = {2379-3694},
number = 7,
volume = 1,
place = {United States},
year = {2016},
month = {5}
}

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