A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca2+ and pH

Nyein, Hnin Yin Yin; Gao, Wei; Shahpar, Ziba; Emaminejad, Sam; Challa, Samyuktha; Chen, Kevin; Fahad, Hossain M.; Tai, Li-Chia; Ota, Hiroki; Davis, Ronald W.; Javey, Ali

doi:10.1021/acsnano.6b04005

Title: A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca²⁺ and pH

Journal Article · Tue Jul 05 00:00:00 EDT 2016 · ACS Nano

DOI:https://doi.org/10.1021/acsnano.6b04005· OSTI ID:1580044

Nyein, Hnin Yin Yin ^[1]; Gao, Wei ^[1]; Shahpar, Ziba ^[2]; Emaminejad, Sam ^[3]; Challa, Samyuktha ^[4]; Chen, Kevin ^[1]; Fahad, Hossain M. ^[2]; Tai, Li-Chia ^[1]; Ota, Hiroki ^[1]; Davis, Ronald W. ^[4]; Javey, Ali ^[1]

Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
Univ. of California, Berkeley, CA (United States)
Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division; Stanford School of Medicine, Palo Alto, CA (United States)
Stanford School of Medicine, Palo Alto, CA (United States)

Homeostasis of ionized calcium in biofluids is critical for human biological functions and organ systems. Measurement of ionized calcium for clinical applications is not easily accessible due to its strict procedures and dependence on pH. pH balance in body fluids greatly affects metabolic reactions and biological transport systems. Here, we demonstrate a wearable electrochemical device for continuous monitoring of ionized calcium and pH of body fluids using a disposable and flexible array of Ca²⁺ and pH sensors that interfaces with a flexible printed circuit board. This platform enables real-time quantitative analysis of these sensing elements in body fluids such as sweat, urine, and tears. Accuracy of Ca²⁺ concentration and pH measured by the wearable sensors is validated through inductively coupled plasma-mass spectrometry technique and a commercial pH meter, respectively. Our results show that the wearable sensors have high repeatability and selectivity to the target ions. Real-time on-body assessment of sweat is also performed, and our results indicate that calcium concentration increases with decreasing pH. Finally, this platform can be used in noninvasive continuous analysis of ionized calcium and pH in body fluids for disease diagnosis such as primary hyperparathyroidism and kidney stones.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: National Science Foundation (NSF)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1580044

Journal Information:: ACS Nano, Vol. 10, Issue 7; ISSN 1936-0851

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 393 works

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References (42)

Ionized Calcium in Body Fluids Robertson, W. G.; Marshall, R. W.; Bowers, George N. CRC Critical Reviews in Clinical Laboratory Sciences, Vol. 15, Issue 2 https://doi.org/10.3109/10408368109105869	journal	January 1981
Metabolic consequences of acid-base disorders Relman, Arnold S. Kidney International, Vol. 1, Issue 5 https://doi.org/10.1038/ki.1972.46	journal	May 1972
Metabolic Basis for Low Urine pH in Type 2 Diabetes Maalouf, Naim M.; Cameron, Mary Ann; Moe, Orson W. Clinical Journal of the American Society of Nephrology, Vol. 5, Issue 7 https://doi.org/10.2215/CJN.08331109	journal	April 2010
The pH of the Skin Surface and Its Impact on the Barrier Function Schmid-Wendtner, M. -H.; Korting, H. C. Skin Pharmacology and Physiology, Vol. 19, Issue 6 https://doi.org/10.1159/000094670	journal	January 2006
Wearable Chemical Sensors: Present Challenges and Future Prospects Bandodkar, Amay J.; Jeerapan, Itthipon; Wang, Joseph ACS Sensors, Vol. 1, Issue 5 https://doi.org/10.1021/acssensors.6b00250	journal	March 2016
Epidermal Electronics Kim, D.-H.; Lu, N.; Ma, R. Science, Vol. 333, Issue 6044, p. 838-843 https://doi.org/10.1126/science.1206157	journal	August 2011
User-interactive electronic skin for instantaneous pressure visualization Wang, Chuan; Hwang, David; Yu, Zhibin Nature Materials, Vol. 12, Issue 10, p. 899-904 https://doi.org/10.1038/nmat3711	journal	July 2013
Flexible polymer transistors with high pressure sensitivity for application in electronic skin and health monitoring Schwartz, Gregor; Tee, Benjamin C. -K.; Mei, Jianguo Nature Communications, Vol. 4, Issue 1 https://doi.org/10.1038/ncomms2832	journal	May 2013
Soft Microfluidic Assemblies of Sensors, Circuits, and Radios for the Skin Xu, Sheng; Zhang, Yihui; Jia, Lin Science, Vol. 344, Issue 6179 https://doi.org/10.1126/science.1250169	journal	April 2014
An ultra-lightweight design for imperceptible plastic electronics Kaltenbrunner, Martin; Sekitani, Tsuyoshi; Reeder, Jonathan Nature, Vol. 499, Issue 7459 https://doi.org/10.1038/nature12314	journal	July 2013
A skin-inspired organic digital mechanoreceptor Tee, B. C. - K.; Chortos, A.; Berndt, A. Science, Vol. 350, Issue 6258 https://doi.org/10.1126/science.aaa9306	journal	October 2015
Toward Flexible and Wearable Human-Interactive Health-Monitoring Devices Takei, Kuniharu; Honda, Wataru; Harada, Shingo Advanced Healthcare Materials, Vol. 4, Issue 4 https://doi.org/10.1002/adhm.201400546	journal	November 2014
Printed Carbon Nanotube Electronics and Sensor Systems Chen, Kevin; Gao, Wei; Emaminejad, Sam Advanced Materials, Vol. 28, Issue 22 https://doi.org/10.1002/adma.201504958	journal	February 2016
Stretchable, Wireless Sensors and Functional Substrates for Epidermal Characterization of Sweat Huang, Xian; Liu, Yuhao; Chen, Kaile Small, Vol. 10, Issue 15 https://doi.org/10.1002/smll.201400483	journal	April 2014
Real-time sweat pH monitoring based on a wearable chemical barcode micro-fluidic platform incorporating ionic liquids Curto, Vincenzo F.; Fay, Cormac; Coyle, Shirley Sensors and Actuators B: Chemical, Vol. 171-172 https://doi.org/10.1016/j.snb.2012.06.048	journal	August 2012
The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications Sonner, Z.; Wilder, E.; Heikenfeld, J. Biomicrofluidics, Vol. 9, Issue 3 https://doi.org/10.1063/1.4921039	journal	May 2015
Tattoo-based potentiometric ion-selective sensors for epidermal pH monitoring Bandodkar, Amay J.; Hung, Vinci W. S.; Jia, Wenzhao The Analyst, Vol. 138, Issue 1 https://doi.org/10.1039/C2AN36422K	journal	January 2013
Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring Bandodkar, Amay J.; Molinnus, Denise; Mirza, Omar Biosensors and Bioelectronics, Vol. 54 https://doi.org/10.1016/j.bios.2013.11.039	journal	April 2014
Electrochemical Tattoo Biosensors for Real-Time Noninvasive Lactate Monitoring in Human Perspiration Jia, Wenzhao; Bandodkar, Amay J.; Valdés-Ramírez, Gabriela Analytical Chemistry, Vol. 85, Issue 14, p. 6553-6560 https://doi.org/10.1021/ac401573r	journal	July 2013
Adhesive RFID Sensor Patch for Monitoring of Sweat Electrolytes Rose, Daniel P.; Ratterman, Michael E.; Griffin, Daniel K. IEEE Transactions on Biomedical Engineering, Vol. 62, Issue 6 https://doi.org/10.1109/TBME.2014.2369991	journal	June 2015
A wearable electrochemical sensor for the real-time measurement of sweat sodium concentration Schazmann, Benjamin; Morris, Deirdre; Slater, Conor Analytical Methods, Vol. 2, Issue 4 https://doi.org/10.1039/b9ay00184k	journal	January 2010
Wearable temporary tattoo sensor for real-time trace metal monitoring in human sweat Kim, Jayoung; de Araujo, William R.; Samek, Izabela A. Electrochemistry Communications, Vol. 51 https://doi.org/10.1016/j.elecom.2014.11.024	journal	February 2015
Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids Gao, Wei; Nyein, Hnin Y. Y.; Shahpar, Ziba ACS Sensors, Vol. 1, Issue 7 https://doi.org/10.1021/acssensors.6b00287	journal	May 2016
A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy Lee, Hyunjae; Choi, Tae Kyu; Lee, Young Bum Nature Nanotechnology, Vol. 11, Issue 6 https://doi.org/10.1038/nnano.2016.38	journal	March 2016
Fluorescent Fiber-Optic Calcium Sensor for Physiological Measurements Shortreed, Michael; Kopelman, Raoul; Kuhn, Michael Analytical Chemistry, Vol. 68, Issue 8 https://doi.org/10.1021/ac950944k	journal	January 1996
An Optical Submicrometer Calcium Sensor with Conductance Sensing Capability Shalom, S.; Strinkovski, A.; Peleg, G. Analytical Biochemistry, Vol. 244, Issue 2 https://doi.org/10.1006/abio.1996.9893	journal	January 1997
Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 2. Ionophores for Potentiometric and Optical Sensors Bühlmann, Philippe; Pretsch, Ernö; Bakker, Eric Chemical Reviews, Vol. 98, Issue 4 https://doi.org/10.1021/cr970113+	journal	June 1998
The Ionophore ETH 129 as Ca2+ Translocator in Artificial and Natural Membranes Prestipino, G.; Falugi, C.; Falchetto, R. Analytical Biochemistry, Vol. 210, Issue 1 https://doi.org/10.1006/abio.1993.1160	journal	April 1993
Calcium ion-selective electrodes under galvanostatic current control Bedlechowicz, Iwona; Sokalski, Tomasz; Lewenstam, Andrzej Sensors and Actuators B: Chemical, Vol. 108, Issue 1-2 https://doi.org/10.1016/j.snb.2004.12.092	journal	July 2005
Calcium-selective electrode based on polyaniline functionalized with bis[4-(1,1,3,3-tetramethylbutyl)phenyl]phosphate Lindfors, Tom; Ivaska, Ari Analytica Chimica Acta, Vol. 437, Issue 2 https://doi.org/10.1016/S0003-2670(01)00996-5	journal	June 2001
Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis Gao, Wei; Emaminejad, Sam; Nyein, Hnin Yin Yin Nature, Vol. 529, Issue 7587 https://doi.org/10.1038/nature16521	journal	January 2016
Advanced Bioelectronic Materials Tiwari, Ashutosh; Patra, Hirak K.; Turner, Anthony P. F. Scrivener Publishing LLC https://doi.org/10.1002/9781118998861	book	October 2015
A reference electrode based on polyvinyl butyral (PVB) polymer for decentralized chemical measurements Guinovart, Tomàs; Crespo, Gastón A.; Rius, F. Xavier Analytica Chimica Acta, Vol. 821 https://doi.org/10.1016/j.aca.2014.02.028	journal	April 2014
Exercise-Induced Trace Mineral Element Concentration in Regional Versus Whole-Body Wash-Down Sweat Baker, Lindsay B.; Stofan, John R.; Lukaski, Henry C. International Journal of Sport Nutrition and Exercise Metabolism, Vol. 21, Issue 3 https://doi.org/10.1123/ijsnem.21.3.233	journal	June 2011
The calcium hypothesis of Cystic Fibrosis Katz, Sidney; Schöni, Martin H.; Bridges, Michael A. Cell Calcium, Vol. 5, Issue 5 https://doi.org/10.1016/0143-4160(84)90021-6	journal	October 1984
Sweat composition in exercise and in heat Verde, T.; Shephard, R. J.; Corey, P. Journal of Applied Physiology, Vol. 53, Issue 6 https://doi.org/10.1152/jappl.1982.53.6.1540	journal	December 1982
Whole body sweat collection in humans: an improved method with preliminary data on electrolyte content Shirreffs, S. M.; Maughan, R. J. Journal of Applied Physiology, Vol. 82, Issue 1 https://doi.org/10.1152/jappl.1997.82.1.336	journal	January 1997
Calcium ion-selective electrode in which a membrane contacts graphite directly Ansaldi, Anthony.; Epstein, S. I. Analytical Chemistry, Vol. 45, Issue 3 https://doi.org/10.1021/ac60325a015	journal	March 1973
Interference by polyamines in the measurement of magnesium ion at physiological pH with the divalent cation-selective electrode Kent, Patricia; Bunce, S. C.; Bailey, R. A. Analytical Biochemistry, Vol. 62, Issue 1 https://doi.org/10.1016/0003-2697(74)90368-6	journal	November 1974
A comparative review of cutaneous pH Matousek, Jennifer L.; Campbell, Karen L. Veterinary Dermatology, Vol. 13, Issue 6 https://doi.org/10.1046/j.1365-3164.2002.00312.x	journal	December 2002
Microfabricated Liquid Junction Ag/AgCl Reference Electrode and Its Application to a One-Chip Potentiometric Sensor Suzuki, Hiroaki; Shiroishi, Hisanori; Sasaki, Satoshi Analytical Chemistry, Vol. 71, Issue 22 https://doi.org/10.1021/ac990437t	journal	October 1999
Clinical Skin Temperature Measurement to Predict Incipient Pressure Ulcers Sprigle, Stephen; Linden, Maureen; McKenna, Diane Advances in Skin & Wound Care, Vol. 14, Issue 3 https://doi.org/10.1097/00129334-200105000-00010	journal	January 2001

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Multifunctional Wearable System that Integrates Sweat-Based Sensing and Vital-Sign Monitoring to Estimate Pre-/Post-Exercise Glucose Levels Hong, Yongseok Joseph; Lee, Hyunjae; Kim, Jaemin Advanced Functional Materials, Vol. 28, Issue 47 https://doi.org/10.1002/adfm.201805754	journal	October 2018
A multi-modal sweat sensing patch for cross-verification of sweat rate, total ionic charge, and Na ⁺ concentration Yuan, Zhen; Hou, Lei; Bariya, Mallika Lab on a Chip, Vol. 19, Issue 19 https://doi.org/10.1039/c9lc00598f	journal	January 2019
Dermal Tattoo Biosensors for Colorimetric Metabolite Detection Yetisen, Ali K.; Moreddu, Rosalia; Seifi, Sarah Angewandte Chemie International Edition, Vol. 58, Issue 31 https://doi.org/10.1002/anie.201904416	journal	July 2019
Wearable Potentiometric Sensors for Medical Applications Cuartero, Maria; Parrilla, Marc; Crespo, Gaston A. Zenodo https://doi.org/10.5281/zenodo.5729347	journalarticle	January 2019
Wearable Potentiometric Sensors for Medical Applications Cuartero, Maria; Parrilla, Marc; Crespo, Gaston A. Zenodo https://doi.org/10.5281/zenodo.5729348	journalarticle	January 2019
Effect of heat-treatment on the pH sensitivity of stainless-steel electrodes as pH sensors Hashimoto, Tadanori; Kitabayashi, Hiroki; Ito, Kenta Heliyon, Vol. 5, Issue 3 https://doi.org/10.1016/j.heliyon.2019.e01239	journal	March 2019
From Point-of-Care Testing to eHealth Diagnostic Devices (eDiagnostics) Christodouleas, Dionysios C.; Kaur, Balwinder; Chorti, Parthena ACS Central Science, Vol. 4, Issue 12 https://doi.org/10.1021/acscentsci.8b00625	journal	November 2018
Highly Sensitive Biosensors Based on Biomolecules and Functional Nanomaterials Depending on the Types of Nanomaterials: A Perspective Review Yoon, Jinho; Shin, Minkyu; Lee, Taek Materials, Vol. 13, Issue 2 https://doi.org/10.3390/ma13020299	journal	January 2020
Fully-Polymeric pH Sensor Realized by Means of a Single-Step Soft Embossing Technique Fanzio, Paola; Chang, Chi-Tung; Skolimowski, Maciej Sensors, Vol. 17, Issue 5 https://doi.org/10.3390/s17051169	journal	May 2017

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Title: A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca2+ and pH

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Title: A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca²⁺ and pH