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Title: Targeting a Large Active Site: Structure‐Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase

Authors:
 [1]; ORCiD logo [2];  [1];  [3]; ORCiD logo [2];  [4]; ORCiD logo [1]
  1. Laboratorium für Organische ChemieETH Zurich Vladimir-Prelog-Weg 3 8093 Zurich Switzerland
  2. Departments of Biochemistry and Medical BiophysicsUniversity of Toronto Medical Sciences Building, 5318, 1 King's College Circle Toronto ON M5S 1A8 Canada; The Campbell Family Institute for Cancer ResearchUniversity Health Network 101 College Street Toronto ON M5G 1L7 Canada
  3. Swiss Tropical and Public Health Institute Socinstrasse 57 4002 Basel Switzerland; University of Basel Petersplatz 1 4003 Basel Switzerland
  4. Biochemie-Zentrum Heidelberg (BZH)Universität Heidelberg Im Neuenheimer Feld 328 69120 Heidelberg Germany
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
FOREIGN
OSTI Identifier:
1577175
Resource Type:
Journal Article
Journal Name:
Chemistry - A European Journal
Additional Journal Information:
Journal Volume: 25; Journal Issue: 49; Journal ID: ISSN 0947-6539
Publisher:
ChemPubSoc Europe
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

De Gasparo, Raoul, Halgas, Ondrej, Harangozo, Dora, Kaiser, Marcel, Pai, Emil F., Krauth‐Siegel, R. Luise, and Diederich, François. Targeting a Large Active Site: Structure‐Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase. United States: N. p., 2019. Web. doi:10.1002/chem.201901664.
De Gasparo, Raoul, Halgas, Ondrej, Harangozo, Dora, Kaiser, Marcel, Pai, Emil F., Krauth‐Siegel, R. Luise, & Diederich, François. Targeting a Large Active Site: Structure‐Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase. United States. doi:10.1002/chem.201901664.
De Gasparo, Raoul, Halgas, Ondrej, Harangozo, Dora, Kaiser, Marcel, Pai, Emil F., Krauth‐Siegel, R. Luise, and Diederich, François. Tue . "Targeting a Large Active Site: Structure‐Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase". United States. doi:10.1002/chem.201901664.
@article{osti_1577175,
title = {Targeting a Large Active Site: Structure‐Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase},
author = {De Gasparo, Raoul and Halgas, Ondrej and Harangozo, Dora and Kaiser, Marcel and Pai, Emil F. and Krauth‐Siegel, R. Luise and Diederich, François},
abstractNote = {},
doi = {10.1002/chem.201901664},
journal = {Chemistry - A European Journal},
issn = {0947-6539},
number = 49,
volume = 25,
place = {United States},
year = {2019},
month = {7}
}