Targeting a Large Active Site: Structure-Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase

De Gasparo, Raoul; Halgas, Ondrej; Harangozo, Dora; Kaiser, Marcel; Pai, Emil F.; Krauth‐Siegel, R. Luise; Diederich, François

doi:10.1002/chem.201901664

Title: Targeting a Large Active Site: Structure-Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase

Journal Article · Tue Jul 09 00:00:00 EDT 2019 · Chemistry - A European Journal

DOI:https://doi.org/10.1002/chem.201901664· OSTI ID:1577175

De Gasparo, Raoul ^[1];

^[2]; Harangozo, Dora ^[1]; Kaiser, Marcel ^[3];

^[2]; Krauth‐Siegel, R. Luise ^[4];

^[1]

Laboratorium für Organische ChemieETH Zurich Vladimir-Prelog-Weg 3 8093 Zurich Switzerland
Departments of Biochemistry and Medical BiophysicsUniversity of Toronto Medical Sciences Building, 5318, 1 King's College Circle Toronto ON M5S 1A8 Canada; The Campbell Family Institute for Cancer ResearchUniversity Health Network 101 College Street Toronto ON M5G 1L7 Canada
Swiss Tropical and Public Health Institute Socinstrasse 57 4002 Basel Switzerland; University of Basel Petersplatz 1 4003 Basel Switzerland
Biochemie-Zentrum Heidelberg (BZH)Universität Heidelberg Im Neuenheimer Feld 328 69120 Heidelberg Germany

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: FOREIGN

OSTI ID:: 1577175

Journal Information:: Chemistry - A European Journal, Vol. 25, Issue 49; ISSN 0947-6539

Publisher:: ChemPubSoc Europe

Country of Publication:: United States

Language:: ENGLISH

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