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Title: Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

Authors:
ORCiD logo [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [2];  [2]; ORCiD logo [2];  [2];  [2];  [3];  [3];  [3];  [3] more »;  [1]; ORCiD logo [2] « less
  1. Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States
  2. Alectos Therapeutics Inc., 8999 Nelson Way, Burnaby, British Columbia V5A 4B5, Canada
  3. Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
INDUSTRY
OSTI Identifier:
1577169
Resource Type:
Journal Article
Journal Name:
Journal of Medicinal Chemistry
Additional Journal Information:
Journal Volume: 62; Journal Issue: 22; Journal ID: ISSN 0022-2623
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Selnick, Harold G., Hess, J. Fred, Tang, Cuyue, Liu, Kun, Schachter, Joel B., Ballard, Jeanine E., Marcus, Jacob, Klein, Daniel J., Wang, Xiaohai, Pearson, Michelle, Savage, Mary J., Kaul, Ramesh, Li, Tong-Shuang, Vocadlo, David J., Zhou, Yuanxi, Zhu, Yongbao, Mu, Changwei, Wang, Yaode, Wei, Zhongyong, Bai, Chang, Duffy, Joseph L., and McEachern, Ernest J. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. United States: N. p., 2019. Web. doi:10.1021/acs.jmedchem.9b01090.
Selnick, Harold G., Hess, J. Fred, Tang, Cuyue, Liu, Kun, Schachter, Joel B., Ballard, Jeanine E., Marcus, Jacob, Klein, Daniel J., Wang, Xiaohai, Pearson, Michelle, Savage, Mary J., Kaul, Ramesh, Li, Tong-Shuang, Vocadlo, David J., Zhou, Yuanxi, Zhu, Yongbao, Mu, Changwei, Wang, Yaode, Wei, Zhongyong, Bai, Chang, Duffy, Joseph L., & McEachern, Ernest J. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. United States. doi:10.1021/acs.jmedchem.9b01090.
Selnick, Harold G., Hess, J. Fred, Tang, Cuyue, Liu, Kun, Schachter, Joel B., Ballard, Jeanine E., Marcus, Jacob, Klein, Daniel J., Wang, Xiaohai, Pearson, Michelle, Savage, Mary J., Kaul, Ramesh, Li, Tong-Shuang, Vocadlo, David J., Zhou, Yuanxi, Zhu, Yongbao, Mu, Changwei, Wang, Yaode, Wei, Zhongyong, Bai, Chang, Duffy, Joseph L., and McEachern, Ernest J. Thu . "Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies". United States. doi:10.1021/acs.jmedchem.9b01090.
@article{osti_1577169,
title = {Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies},
author = {Selnick, Harold G. and Hess, J. Fred and Tang, Cuyue and Liu, Kun and Schachter, Joel B. and Ballard, Jeanine E. and Marcus, Jacob and Klein, Daniel J. and Wang, Xiaohai and Pearson, Michelle and Savage, Mary J. and Kaul, Ramesh and Li, Tong-Shuang and Vocadlo, David J. and Zhou, Yuanxi and Zhu, Yongbao and Mu, Changwei and Wang, Yaode and Wei, Zhongyong and Bai, Chang and Duffy, Joseph L. and McEachern, Ernest J.},
abstractNote = {},
doi = {10.1021/acs.jmedchem.9b01090},
journal = {Journal of Medicinal Chemistry},
issn = {0022-2623},
number = 22,
volume = 62,
place = {United States},
year = {2019},
month = {9}
}