Molecular characteristics of plant UDP-arabinopyranose mutases

Saqib, Anam; Scheller, Henrik Vibe; Fredslund, Folmer; Welner, Ditte Hededam

doi:10.1093/glycob/cwz067

Title: Molecular characteristics of plant UDP-arabinopyranose mutases

Journal Article · Wed May 15 00:00:00 EDT 2019 · Glycobiology

DOI:https://doi.org/10.1093/glycob/cwz067· OSTI ID:1573880

Saqib, Anam ^[1]; Scheller, Henrik Vibe ^[2]; Fredslund, Folmer ^[3];

^[3]

Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, Kongens Lyngby, DK-2800, Denmark, Industrial Enzymes and Biofuels Group, National Institute for Biotechnology and Genetic Engineering, Jhang Road, 44000 Faisalabad, Pakistan
Feedstocks Division, Joint BioEnergy Institute, 5885 Hollis Street, Emeryville, CA 94608, USA, Environmental Engineering and Systems Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA, Department of Plant & Microbial Biology, University of California, Berkeley, CA 94720, USA
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, Kongens Lyngby, DK-2800, Denmark

Abstract l-arabinofuranose is a ubiquitous component of the cell wall and various natural products in plants, where it is synthesized from cytosolic UDP-arabinopyranose. The biosynthetic machinery long remained enigmatic in terms of responsible enzymes and subcellular localization. With the discovery of UDP-arabinopyranose mutase in plant cytosol, the demonstration of its role in cell-wall arabinose incorporation, and the identification of UDP-arabinofuranose transporters in the Golgi membrane, it is clear that the cytosolic UDP-arabinopyranose mutases are the key enzymes converting UDP-arabinopyranose to UDP-arabinofuranose for cell wall and natural product biosynthesis. This has recently been confirmed by several genotype/phenotype studies. In contrast to the solid evidence pertaining to UDP-arabinopyranose mutase function in vivo, the molecular features, including enzymatic mechanism and oligomeric state, remain unknown. However, these enzymes belong to the small family of proteins originally identified as reversibly glycosylated polypeptides, which has been studied for more than 20 years. Here, we review the UDP-arabinopyranose mutase and reversibly glycosylated polypeptide literature together, to summarize and systemize reported molecular characteristics and relations to other proteins.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1573880

Alternate ID(s):: OSTI ID: 1560694; OSTI ID: 1576508

Journal Information:: Glycobiology, Journal Name: Glycobiology Vol. 29 Journal Issue: 12; ISSN 0959-6658

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Cited by: 14 works

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