Solution target for cyclotron production of radiometals

Patent · 08 October 2019

OSTI ID:1576447

Degrado, Timothy R.; Pandey, Mukesh K.; Byrne, John

Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.

• Research Organization: Mayo Foundation for Medical Education and Research, Rochester, MN (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: SC0008947
• Assignee: Mayo Foundation for Medical Education and Research (Rochester, MN)
• Patent Number(s): 10,438,712
• Application Number: 15/493,310
• OSTI ID: 1576447
• Country of Publication: United States
• Language: English