skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability

Authors:
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; more »; ; ; ; ; ; ; ;  [1] « less
  1. BMS
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
INDUSTRY
OSTI Identifier:
1572535
Resource Type:
Journal Article
Journal Name:
Bioorg. Med. Chem. Lett.
Additional Journal Information:
Journal Volume: 29; Journal Issue: (19) ; 10, 2019
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Clark, Charles G., Rossi, Karen A., Corte, James R., Fang, Tianan, Smallheer, Joanne M., De Lucca, Indawati, Nirschl, David S., Orwat, Michael J., Pinto, Donald J.P., Hu, Zilun, Wang, Yufeng, Yang, Wu, Jeon, Yoon, Ewing, William R., Myers, Jr., Joseph E., Sheriff, Steven, Lou, Zhen, Bozarth, Jeffrey M., Wu, Yiming, Rendina, Alan, Harper, Timothy, Zheng, Joanna, Xin, Baomin, Xiang, Qian, Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., and Lam, Patrick Y.S. Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability. United States: N. p., 2019. Web. doi:10.1016/j.bmcl.2019.08.008.
Clark, Charles G., Rossi, Karen A., Corte, James R., Fang, Tianan, Smallheer, Joanne M., De Lucca, Indawati, Nirschl, David S., Orwat, Michael J., Pinto, Donald J.P., Hu, Zilun, Wang, Yufeng, Yang, Wu, Jeon, Yoon, Ewing, William R., Myers, Jr., Joseph E., Sheriff, Steven, Lou, Zhen, Bozarth, Jeffrey M., Wu, Yiming, Rendina, Alan, Harper, Timothy, Zheng, Joanna, Xin, Baomin, Xiang, Qian, Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., & Lam, Patrick Y.S. Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability. United States. doi:10.1016/j.bmcl.2019.08.008.
Clark, Charles G., Rossi, Karen A., Corte, James R., Fang, Tianan, Smallheer, Joanne M., De Lucca, Indawati, Nirschl, David S., Orwat, Michael J., Pinto, Donald J.P., Hu, Zilun, Wang, Yufeng, Yang, Wu, Jeon, Yoon, Ewing, William R., Myers, Jr., Joseph E., Sheriff, Steven, Lou, Zhen, Bozarth, Jeffrey M., Wu, Yiming, Rendina, Alan, Harper, Timothy, Zheng, Joanna, Xin, Baomin, Xiang, Qian, Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., and Lam, Patrick Y.S. Fri . "Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability". United States. doi:10.1016/j.bmcl.2019.08.008.
@article{osti_1572535,
title = {Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability},
author = {Clark, Charles G. and Rossi, Karen A. and Corte, James R. and Fang, Tianan and Smallheer, Joanne M. and De Lucca, Indawati and Nirschl, David S. and Orwat, Michael J. and Pinto, Donald J.P. and Hu, Zilun and Wang, Yufeng and Yang, Wu and Jeon, Yoon and Ewing, William R. and Myers, Jr., Joseph E. and Sheriff, Steven and Lou, Zhen and Bozarth, Jeffrey M. and Wu, Yiming and Rendina, Alan and Harper, Timothy and Zheng, Joanna and Xin, Baomin and Xiang, Qian and Luettgen, Joseph M. and Seiffert, Dietmar A. and Wexler, Ruth R. and Lam, Patrick Y.S.},
abstractNote = {},
doi = {10.1016/j.bmcl.2019.08.008},
journal = {Bioorg. Med. Chem. Lett.},
number = (19) ; 10, 2019,
volume = 29,
place = {United States},
year = {2019},
month = {10}
}