skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Ultrasmall sample biochemical analysis

Abstract

Richard Feynman’s landmark lecture from 1959 titled BThere’s Plenty of Room at the Bottom: An Invitation to Enter a New Field of Physics^ is widely known for encouraging research into the field we now refer to as nanotechnology. In that same lecture, he also presciently recognized that many fundamental questions in biology could be answered through miniaturization, particularly using microscopy, noting that many knowledge gaps could be readily addressed if we could Bjust look at the thing!^ Indeed, increasing the resolution with which biological systems are investigated, whether it be through cryoelectron microscopy, flow cytometry, or singlecell RNA-Seq, has revolutionized many aspects of biological inquiry. In this themed topical collection of Analytical and Bioanalytical Chemistry, we emphasize that there is still Bplenty of room at the bottom^ when it comes to biochemical analysis. Great strides have been made in biology and medicine as chemical measurements that have historically been applied to bulk tissues are extended to the scale at which the biology is occurring, which is often at the cellular or subcellular level.

Authors:
ORCiD logo [1]; ORCiD logo [2]
  1. BRIGHAM YOUNG UNIVERSITY
  2. BATTELLE (PACIFIC NW LAB)
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1572461
Report Number(s):
PNNL-SA-146523
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Analytical and Bioanalytical Chemistry
Additional Journal Information:
Journal Volume: 411; Journal Issue: 21
Country of Publication:
United States
Language:
English

Citation Formats

Kelly, Ryan T., and Zhu, Ying. Ultrasmall sample biochemical analysis. United States: N. p., 2019. Web. doi:10.1007/s00216-019-01957-1.
Kelly, Ryan T., & Zhu, Ying. Ultrasmall sample biochemical analysis. United States. doi:10.1007/s00216-019-01957-1.
Kelly, Ryan T., and Zhu, Ying. Thu . "Ultrasmall sample biochemical analysis". United States. doi:10.1007/s00216-019-01957-1.
@article{osti_1572461,
title = {Ultrasmall sample biochemical analysis},
author = {Kelly, Ryan T. and Zhu, Ying},
abstractNote = {Richard Feynman’s landmark lecture from 1959 titled BThere’s Plenty of Room at the Bottom: An Invitation to Enter a New Field of Physics^ is widely known for encouraging research into the field we now refer to as nanotechnology. In that same lecture, he also presciently recognized that many fundamental questions in biology could be answered through miniaturization, particularly using microscopy, noting that many knowledge gaps could be readily addressed if we could Bjust look at the thing!^ Indeed, increasing the resolution with which biological systems are investigated, whether it be through cryoelectron microscopy, flow cytometry, or singlecell RNA-Seq, has revolutionized many aspects of biological inquiry. In this themed topical collection of Analytical and Bioanalytical Chemistry, we emphasize that there is still Bplenty of room at the bottom^ when it comes to biochemical analysis. Great strides have been made in biology and medicine as chemical measurements that have historically been applied to bulk tissues are extended to the scale at which the biology is occurring, which is often at the cellular or subcellular level.},
doi = {10.1007/s00216-019-01957-1},
journal = {Analytical and Bioanalytical Chemistry},
number = 21,
volume = 411,
place = {United States},
year = {2019},
month = {8}
}