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Title: Hierarchical Assembly of Peptoid-Based Cylindrical Micelles Exhibiting Efficient Resonance Energy Transfer in Aqueous Solution

Abstract

Herein we showthat by appending bulky b-cyclodextrin (CD) groups onto sheet-forming peptoids,weobtain cylindrical micelles that further assembly into membranes and intertwined ribbons on substrates in aqueous solution, depending on the choice of solution and substrate conditions.Insitu atomic force microscopy(AFM) shows that micelle assembly occurs in two steps,starting with “precursor” particles that transform into worm-like micelles,whichextend and coalesce to form the higher order structures with arate and adegree of cooperativity dependent on pH and Ca2+ concentration. After co-assembly with hydrophobic 4-(2-hydroxyethylamino)-7nitro-2,1,3-benzoxadiazole (NBD) donors that occupyt he hydrophobic core,followed by exposure to hydrophilic Rhodamine Basacceptors that insert into cyclodextrin, the micelles exhibit highly efficient Fçrster resonance energy transfer efficiency in aqueous solution, thereby mimicking natural light harvesting systems.

Authors:
 [1];  [1];  [2]; ORCiD logo [2]; ORCiD logo [2];  [3];  [2];  [2]
  1. UNIVERSITY PROGRAMS
  2. BATTELLE (PACIFIC NW LAB)
  3. East China Normal University
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1571481
Report Number(s):
PNNL-SA-148211
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Angewandte Chemie International Edition
Additional Journal Information:
Journal Volume: 58; Journal Issue: 5
Country of Publication:
United States
Language:
English
Subject:
Fçrster resonance energy transfer, hierarchical assembly, micelles, membranes, peptoids

Citation Formats

Jiao, Fang, Wu, Xuepeng, Jian, Teng-Yue, Zhang, Shuai, Jin, Haibao, He, Pingang, Chen, Chunlong, and De Yoreo, James J. Hierarchical Assembly of Peptoid-Based Cylindrical Micelles Exhibiting Efficient Resonance Energy Transfer in Aqueous Solution. United States: N. p., 2019. Web. doi:10.1002/anie.201904598.
Jiao, Fang, Wu, Xuepeng, Jian, Teng-Yue, Zhang, Shuai, Jin, Haibao, He, Pingang, Chen, Chunlong, & De Yoreo, James J. Hierarchical Assembly of Peptoid-Based Cylindrical Micelles Exhibiting Efficient Resonance Energy Transfer in Aqueous Solution. United States. doi:10.1002/anie.201904598.
Jiao, Fang, Wu, Xuepeng, Jian, Teng-Yue, Zhang, Shuai, Jin, Haibao, He, Pingang, Chen, Chunlong, and De Yoreo, James J. Mon . "Hierarchical Assembly of Peptoid-Based Cylindrical Micelles Exhibiting Efficient Resonance Energy Transfer in Aqueous Solution". United States. doi:10.1002/anie.201904598.
@article{osti_1571481,
title = {Hierarchical Assembly of Peptoid-Based Cylindrical Micelles Exhibiting Efficient Resonance Energy Transfer in Aqueous Solution},
author = {Jiao, Fang and Wu, Xuepeng and Jian, Teng-Yue and Zhang, Shuai and Jin, Haibao and He, Pingang and Chen, Chunlong and De Yoreo, James J.},
abstractNote = {Herein we showthat by appending bulky b-cyclodextrin (CD) groups onto sheet-forming peptoids,weobtain cylindrical micelles that further assembly into membranes and intertwined ribbons on substrates in aqueous solution, depending on the choice of solution and substrate conditions.Insitu atomic force microscopy(AFM) shows that micelle assembly occurs in two steps,starting with “precursor” particles that transform into worm-like micelles,whichextend and coalesce to form the higher order structures with arate and adegree of cooperativity dependent on pH and Ca2+ concentration. After co-assembly with hydrophobic 4-(2-hydroxyethylamino)-7nitro-2,1,3-benzoxadiazole (NBD) donors that occupyt he hydrophobic core,followed by exposure to hydrophilic Rhodamine Basacceptors that insert into cyclodextrin, the micelles exhibit highly efficient Fçrster resonance energy transfer efficiency in aqueous solution, thereby mimicking natural light harvesting systems.},
doi = {10.1002/anie.201904598},
journal = {Angewandte Chemie International Edition},
number = 5,
volume = 58,
place = {United States},
year = {2019},
month = {8}
}