skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe–2S cluster

Authors:
ORCiD logo; ; ; ; ; ; ORCiD logo; ; ORCiD logo
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
FOREIGN
OSTI Identifier:
1569878
Resource Type:
Journal Article
Journal Name:
Journal of Biological Chemistry
Additional Journal Information:
Journal Volume: 294; Journal Issue: 35; Journal ID: ISSN 0021-9258
Publisher:
American Society for Biochemistry and Molecular Biology
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Bashiri, Ghader, Grove, Tyler L., Hegde, Subray S., Lagautriere, Thomas, Gerfen, Gary J., Almo, Steven C., Squire, Christopher J., Blanchard, John S., and Baker, Edward N. The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe–2S cluster. United States: N. p., 2019. Web. doi:10.1074/jbc.RA119.009498.
Bashiri, Ghader, Grove, Tyler L., Hegde, Subray S., Lagautriere, Thomas, Gerfen, Gary J., Almo, Steven C., Squire, Christopher J., Blanchard, John S., & Baker, Edward N. The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe–2S cluster. United States. doi:10.1074/jbc.RA119.009498.
Bashiri, Ghader, Grove, Tyler L., Hegde, Subray S., Lagautriere, Thomas, Gerfen, Gary J., Almo, Steven C., Squire, Christopher J., Blanchard, John S., and Baker, Edward N. Tue . "The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe–2S cluster". United States. doi:10.1074/jbc.RA119.009498.
@article{osti_1569878,
title = {The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe–2S cluster},
author = {Bashiri, Ghader and Grove, Tyler L. and Hegde, Subray S. and Lagautriere, Thomas and Gerfen, Gary J. and Almo, Steven C. and Squire, Christopher J. and Blanchard, John S. and Baker, Edward N.},
abstractNote = {},
doi = {10.1074/jbc.RA119.009498},
journal = {Journal of Biological Chemistry},
issn = {0021-9258},
number = 35,
volume = 294,
place = {United States},
year = {2019},
month = {7}
}

Works referenced in this record:

High-level expression and reconstitution of active Cfr, a radical-SAM rRNA methyltransferase that confers resistance to ribosome-acting antibiotics
journal, December 2010

  • Booth, Michael P. S.; Challand, Martin R.; Emery, David C.
  • Protein Expression and Purification, Vol. 74, Issue 2
  • DOI: 10.1016/j.pep.2010.07.010

Development and validation of a genetic algorithm for flexible docking 1 1Edited by F. E. Cohen
journal, April 1997

  • Jones, Gareth; Willett, Peter; Glen, Robert C.
  • Journal of Molecular Biology, Vol. 267, Issue 3
  • DOI: 10.1006/jmbi.1996.0897

Reactivity of nitric oxide with the [4Fe–4S] cluster of dihydroxyacid dehydratase from Escherichia coli
journal, January 2009

  • Duan, Xuewu; Yang, Juanjuan; Ren, Binbin
  • Biochemical Journal, Vol. 417, Issue 3
  • DOI: 10.1042/BJ20081423

Structural and Catalytic Diversity within the Amidohydrolase Superfamily
journal, May 2005

  • Seibert, Clara M.; Raushel, Frank M.
  • Biochemistry, Vol. 44, Issue 17
  • DOI: 10.1021/bi047326v

Bacterial Branched-Chain Amino Acid Biosynthesis: Structures, Mechanisms, and Drugability
journal, October 2017


MolProbity : all-atom structure validation for macromolecular crystallography
journal, December 2009

  • Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1
  • DOI: 10.1107/S0907444909042073

Crystal structures of aconitase with isocitrate and nitroisocitrate bound
journal, March 1992

  • Lauble, H.; Kennedy, M. C.; Beinert, H.
  • Biochemistry, Vol. 31, Issue 10
  • DOI: 10.1021/bi00125a014

Features and development of Coot
journal, March 2010

  • Emsley, P.; Lohkamp, B.; Scott, W. G.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
  • DOI: 10.1107/S0907444910007493

The crystal structure of D-xylonate dehydratase reveals functional features of enzymes from the Ilv/ED dehydratase family
journal, January 2018


REFMAC 5 for the refinement of macromolecular crystal structures
journal, March 2011

  • Murshudov, Garib N.; Skubák, Pavol; Lebedev, Andrey A.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4
  • DOI: 10.1107/S0907444911001314

Towards automated crystallographic structure refinement with phenix.refine
journal, March 2012

  • Afonine, Pavel V.; Grosse-Kunstleve, Ralf W.; Echols, Nathaniel
  • Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 4
  • DOI: 10.1107/S0907444912001308

The Crystal Structure of a Bacterial l -Arabinonate Dehydratase Contains a [2Fe-2S] Cluster
journal, June 2017

  • Rahman, Mohammad Mubinur; Andberg, Martina; Thangaraj, Senthil Kumar
  • ACS Chemical Biology, Vol. 12, Issue 7
  • DOI: 10.1021/acschembio.7b00304

Alternative FeS cluster ligands: tuning redox potentials and chemistry
journal, April 2014


Downregulation of Rv0189c, encoding a dihydroxyacid dehydratase, affects growth of Mycobacterium tuberculosis in vitro and in mice
journal, September 2010


Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions
journal, November 2004

  • Krissinel, E.; Henrick, K.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12
  • DOI: 10.1107/S0907444904026460

Genes required for mycobacterial growth defined by high density mutagenesis: Genes required for mycobacterial growth
journal, March 2003


Aconitase as Iron−Sulfur Protein, Enzyme, and Iron-Regulatory Protein
journal, January 1996

  • Beinert, Helmut; Kennedy, Mary Claire; Stout, C. David
  • Chemical Reviews, Vol. 96, Issue 7
  • DOI: 10.1021/cr950040z

Multiple Rieske proteins in prokaryotes: Where and why?
journal, November 2005

  • Schneider, Dirk; Schmidt, Christian L.
  • Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1710, Issue 1
  • DOI: 10.1016/j.bbabio.2005.09.003

NMRPipe: A multidimensional spectral processing system based on UNIX pipes
journal, November 1995

  • Delaglio, Frank; Grzesiek, Stephan; Vuister, GeertenW.
  • Journal of Biomolecular NMR, Vol. 6, Issue 3
  • DOI: 10.1007/BF00197809

Isolation and properties of an iron-protein from the (reduced coenzyme Q)-cytochrome C reductase complex of the respiratory chain
journal, April 1964

  • Rieske, John S.; MacLennan, David H.; Coleman, Roger
  • Biochemical and Biophysical Research Communications, Vol. 15, Issue 4
  • DOI: 10.1016/0006-291X(64)90171-8

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7
journal, June 2008

  • Langer, Gerrit; Cohen, Serge X.; Lamzin, Victor S.
  • Nature Protocols, Vol. 3, Issue 7
  • DOI: 10.1038/nprot.2008.91

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action
journal, July 2018


Characterization of MOCS1A, an Oxygen-sensitive Iron-Sulfur Protein Involved in Human Molybdenum Cofactor Biosynthesis
journal, June 2004

  • Hänzelmann, Petra; Hernández, Heather L.; Menzel, Christian
  • Journal of Biological Chemistry, Vol. 279, Issue 33
  • DOI: 10.1074/jbc.M313398200

Stereoselectivity and stereospecificity of the α,β-dihydroxyacid dehydratase and from Salmonella typhimurium
journal, July 1977

  • Armstrong, Frank B.; Muller, Urs S.; Reary, James B.
  • Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 498, Issue 2
  • DOI: 10.1016/0304-4165(77)90266-5

Iron−Sulfur Proteins with Nonredox Functions
journal, January 1996

  • Flint, Dennis H.; Allen, Ronda M.
  • Chemical Reviews, Vol. 96, Issue 7
  • DOI: 10.1021/cr950041r