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Title: 2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building Blocks

Abstract

The successful integration of 2D nanomaterials into functional devices hinges on developing fabrication methods that afford hierarchical control across length scales of the entire assembly. We demonstrate structural control over a class of crystalline 2D nanosheets assembled from collagen triple helices. By lengthening the triple helix unit through sequential additions of Pro-Hyp-Gly triads, we achieved sub-angstrom tuning over the 2D lattice. These subtle changes influence the overall nanosheet size, which can be adjusted across the mesoscale size regime. The internal structure was observed by cryo-TEM with direct electron detection, which provides realspace high-resolution images, in which individual triple helices comprising the lattice can be clearly discerned. These results establish a general strategy for tuning the structural hierarchy of 2D nanomaterials that employ rigid, cylindrical structural units.

Authors:
; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1569846
DOE Contract Number:  
AC02-06CH11357
Resource Type:
Journal Article
Journal Name:
Angewandte Chemie (International Edition)
Additional Journal Information:
Journal Volume: 58; Journal Issue: 38
Country of Publication:
United States
Language:
English
Subject:
biomaterials; collagen-mimetic peptides; nanoarchitectonics; nanosheets; self-assembly

Citation Formats

Merg, Andrea D., Touponse, Gavin, Genderen, Eric van, Zuo, Xiaobing, Bazrafshan, Alisina, Blum, Thorsten, Hughes, Spencer, Salaita, Khalid, Abrahams, Jan Pieter, and Conticello, Vincent P. 2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building Blocks. United States: N. p., 2019. Web. doi:10.1002/anie.201906214.
Merg, Andrea D., Touponse, Gavin, Genderen, Eric van, Zuo, Xiaobing, Bazrafshan, Alisina, Blum, Thorsten, Hughes, Spencer, Salaita, Khalid, Abrahams, Jan Pieter, & Conticello, Vincent P. 2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building Blocks. United States. doi:10.1002/anie.201906214.
Merg, Andrea D., Touponse, Gavin, Genderen, Eric van, Zuo, Xiaobing, Bazrafshan, Alisina, Blum, Thorsten, Hughes, Spencer, Salaita, Khalid, Abrahams, Jan Pieter, and Conticello, Vincent P. Mon . "2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building Blocks". United States. doi:10.1002/anie.201906214.
@article{osti_1569846,
title = {2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building Blocks},
author = {Merg, Andrea D. and Touponse, Gavin and Genderen, Eric van and Zuo, Xiaobing and Bazrafshan, Alisina and Blum, Thorsten and Hughes, Spencer and Salaita, Khalid and Abrahams, Jan Pieter and Conticello, Vincent P.},
abstractNote = {The successful integration of 2D nanomaterials into functional devices hinges on developing fabrication methods that afford hierarchical control across length scales of the entire assembly. We demonstrate structural control over a class of crystalline 2D nanosheets assembled from collagen triple helices. By lengthening the triple helix unit through sequential additions of Pro-Hyp-Gly triads, we achieved sub-angstrom tuning over the 2D lattice. These subtle changes influence the overall nanosheet size, which can be adjusted across the mesoscale size regime. The internal structure was observed by cryo-TEM with direct electron detection, which provides realspace high-resolution images, in which individual triple helices comprising the lattice can be clearly discerned. These results establish a general strategy for tuning the structural hierarchy of 2D nanomaterials that employ rigid, cylindrical structural units.},
doi = {10.1002/anie.201906214},
journal = {Angewandte Chemie (International Edition)},
number = 38,
volume = 58,
place = {United States},
year = {2019},
month = {9}
}

Works referenced in this record:

Electric Field Effect in Atomically Thin Carbon Films
journal, October 2004