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Title: Development of 211-Astatine Production in the Crocker Nuclear Laboratory Cyclotron

Abstract

There is a great deal of interest in the medical community in the use of the alpha-emitter 211-At as a therapeutic isotope. Among other things, its 7.2 hour half life is long enough to allow for recovery and labeling, but short enough to avoid long term activity in patients. Unfortunately, the only practical technique for its production is to bombard a 209-Bi target with a ~29 MeV alpha beam, so it is not accessible to commercial isotope production facilities, which all use fixed energy proton beams. The US Department of Energy is therefore supporting the development of a "University Isotope Network" (UIN) to satisfy this need. Our prposoal is to retrofit the variable-energy, multi-species cyclotron at the Crocker Nuclear Laboratory at the University of California Davis with an internal Bi-209 target, such that we can put at least 100 uA of 29 MeV alpha particles on target without concerns about extraction efficiency. Using very conservative assumptions, we are confident we will be able to produce 60 mCi of 211-At in solution in an eight hour shift, which includes setup, exposure, and chemical recovery. This poster will cover the design of the target, as well as the required chemical processing andmore » reliability upgrades.« less

Authors:
ORCiD logo [1];  [2];  [3];  [4]
  1. Fermilab
  2. UC, Berkeley
  3. UC, Davis
  4. UC, Davis, Dept. Math.
Publication Date:
Research Org.:
Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC), High Energy Physics (HEP) (SC-25)
OSTI Identifier:
1568870
Report Number(s):
FERMILAB-CONF-19-449-APC
oai:inspirehep.net:1745606
DOE Contract Number:  
AC02-07CH11359
Resource Type:
Conference
Resource Relation:
Conference: 10th International Particle Accelerator Conference, Melbourne, Australia, 05/19-05/24/2019
Country of Publication:
United States
Language:
English
Subject:
43 PARTICLE ACCELERATORS

Citation Formats

Prebys, Eric, Abergel, Rebecca, Casey, William, and Cebra, Daniel. Development of 211-Astatine Production in the Crocker Nuclear Laboratory Cyclotron. United States: N. p., 2019. Web. doi:10.18429/JACoW-IPAC2019-THPMP051.
Prebys, Eric, Abergel, Rebecca, Casey, William, & Cebra, Daniel. Development of 211-Astatine Production in the Crocker Nuclear Laboratory Cyclotron. United States. doi:10.18429/JACoW-IPAC2019-THPMP051.
Prebys, Eric, Abergel, Rebecca, Casey, William, and Cebra, Daniel. Mon . "Development of 211-Astatine Production in the Crocker Nuclear Laboratory Cyclotron". United States. doi:10.18429/JACoW-IPAC2019-THPMP051. https://www.osti.gov/servlets/purl/1568870.
@article{osti_1568870,
title = {Development of 211-Astatine Production in the Crocker Nuclear Laboratory Cyclotron},
author = {Prebys, Eric and Abergel, Rebecca and Casey, William and Cebra, Daniel},
abstractNote = {There is a great deal of interest in the medical community in the use of the alpha-emitter 211-At as a therapeutic isotope. Among other things, its 7.2 hour half life is long enough to allow for recovery and labeling, but short enough to avoid long term activity in patients. Unfortunately, the only practical technique for its production is to bombard a 209-Bi target with a ~29 MeV alpha beam, so it is not accessible to commercial isotope production facilities, which all use fixed energy proton beams. The US Department of Energy is therefore supporting the development of a "University Isotope Network" (UIN) to satisfy this need. Our prposoal is to retrofit the variable-energy, multi-species cyclotron at the Crocker Nuclear Laboratory at the University of California Davis with an internal Bi-209 target, such that we can put at least 100 uA of 29 MeV alpha particles on target without concerns about extraction efficiency. Using very conservative assumptions, we are confident we will be able to produce 60 mCi of 211-At in solution in an eight hour shift, which includes setup, exposure, and chemical recovery. This poster will cover the design of the target, as well as the required chemical processing and reliability upgrades.},
doi = {10.18429/JACoW-IPAC2019-THPMP051},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {6}
}

Conference:
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