skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Coupling of an atmospheric pressure microplasma ionization source with an Orbitrap Fusion Lumos Tribrid 1M mass analyzer for ultra-high resolution isotopic analysis of uranium

Abstract

The coupling of the liquid sampling-atmospheric pressure glow discharge (LSAPGD) microplasma to an Orbitrap Fusion Lumos Tribrid mass spectrometer is described as a significant step towards the elimination of isobaric interferences in elemental/isotopic mass spectrometry. The developed setup permits broadband, elemental mass spectra to be easily acquired at a mass resolution (m/?m) of 500,000. A new ion source housing and integrated control system provide enhanced stability and sensitivity of the microplasma ion source in comparison to the previous designs. Detailed evaluation of the ion sampling parameters provided insight into differences with other Orbitrap platforms leading to a 5-fold increase in resolution in elemental/isotopic analysis. The roles of data acquisition/ion processing parameters were evaluated with regards to the precision and accuracy of 235U/238U isotope ratios. Significantly, the precision of those measurements improves as a function of pre-set mass resolution up to a value of 1,000,000, where a precision of 0.086 %RSD is obtained for uranium concentrations of 100 ng mL-1. Analytical response curves (log-log), acquired for the two uranium isotopes at a resolution of 120,000 were linear (R2=0.9969) over more than 5 orders of magnitude, with limits of detection of 1 pg mL-1. Based on 60 ?L injection volumes, this representsmore » a mass of 70 fg 235U. These figures of merit satisfy International Target Values (ITVs) for Measurement Uncertainties in Safeguarding Nuclear Materials set by the International Atomic Energy Agency (IAEA). Page 2 of 33 ACS Paragon Plus Environment Analytical Chemistry 123456789 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53« less

Authors:
 [1];  [2];  [3];  [4];  [1];  [5]
  1. BATTELLE (PACIFIC NW LAB)
  2. CNRS, Institute for Analytical and Physical Chemistry of the Environment and Materials
  3. CNRS, Institute of Analytical and Physical Chemistry of the Environment and Materials
  4. CNRS Institute for Anaylitical and Physical Chemistry of the Environment and Materials
  5. Clemson University
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1568059
Report Number(s):
PNNL-SA-142442
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Journal of Analytical Atomic Spectrometry
Additional Journal Information:
Journal Volume: 34; Journal Issue: 7
Country of Publication:
United States
Language:
English

Citation Formats

Hoegg, Edward D., Godin, Simon, Szpunar, Joanna, Lobinski, Ryszard, Koppenaal, David W., and Marcus, R. Kenneth. Coupling of an atmospheric pressure microplasma ionization source with an Orbitrap Fusion Lumos Tribrid 1M mass analyzer for ultra-high resolution isotopic analysis of uranium. United States: N. p., 2019. Web. doi:10.1039/C9JA00154A.
Hoegg, Edward D., Godin, Simon, Szpunar, Joanna, Lobinski, Ryszard, Koppenaal, David W., & Marcus, R. Kenneth. Coupling of an atmospheric pressure microplasma ionization source with an Orbitrap Fusion Lumos Tribrid 1M mass analyzer for ultra-high resolution isotopic analysis of uranium. United States. doi:10.1039/C9JA00154A.
Hoegg, Edward D., Godin, Simon, Szpunar, Joanna, Lobinski, Ryszard, Koppenaal, David W., and Marcus, R. Kenneth. Mon . "Coupling of an atmospheric pressure microplasma ionization source with an Orbitrap Fusion Lumos Tribrid 1M mass analyzer for ultra-high resolution isotopic analysis of uranium". United States. doi:10.1039/C9JA00154A.
@article{osti_1568059,
title = {Coupling of an atmospheric pressure microplasma ionization source with an Orbitrap Fusion Lumos Tribrid 1M mass analyzer for ultra-high resolution isotopic analysis of uranium},
author = {Hoegg, Edward D. and Godin, Simon and Szpunar, Joanna and Lobinski, Ryszard and Koppenaal, David W. and Marcus, R. Kenneth},
abstractNote = {The coupling of the liquid sampling-atmospheric pressure glow discharge (LSAPGD) microplasma to an Orbitrap Fusion Lumos Tribrid mass spectrometer is described as a significant step towards the elimination of isobaric interferences in elemental/isotopic mass spectrometry. The developed setup permits broadband, elemental mass spectra to be easily acquired at a mass resolution (m/?m) of 500,000. A new ion source housing and integrated control system provide enhanced stability and sensitivity of the microplasma ion source in comparison to the previous designs. Detailed evaluation of the ion sampling parameters provided insight into differences with other Orbitrap platforms leading to a 5-fold increase in resolution in elemental/isotopic analysis. The roles of data acquisition/ion processing parameters were evaluated with regards to the precision and accuracy of 235U/238U isotope ratios. Significantly, the precision of those measurements improves as a function of pre-set mass resolution up to a value of 1,000,000, where a precision of 0.086 %RSD is obtained for uranium concentrations of 100 ng mL-1. Analytical response curves (log-log), acquired for the two uranium isotopes at a resolution of 120,000 were linear (R2=0.9969) over more than 5 orders of magnitude, with limits of detection of 1 pg mL-1. Based on 60 ?L injection volumes, this represents a mass of 70 fg 235U. These figures of merit satisfy International Target Values (ITVs) for Measurement Uncertainties in Safeguarding Nuclear Materials set by the International Atomic Energy Agency (IAEA). Page 2 of 33 ACS Paragon Plus Environment Analytical Chemistry 123456789 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53},
doi = {10.1039/C9JA00154A},
journal = {Journal of Analytical Atomic Spectrometry},
number = 7,
volume = 34,
place = {United States},
year = {2019},
month = {7}
}

Works referenced in this record:

Reaction cells and collision cells for ICP-MS: a tutorial review
journal, September 2002

  • Tanner, Scott D.; Baranov, Vladimir I.; Bandura, Dmitry R.
  • Spectrochimica Acta Part B: Atomic Spectroscopy, Vol. 57, Issue 9
  • DOI: 10.1016/S0584-8547(02)00069-1

Overcoming spectral overlap via inductively coupled plasma-tandem mass spectrometry (ICP-MS/MS). A tutorial review
journal, January 2017

  • Bolea-Fernandez, Eduardo; Balcaen, Lieve; Resano, Martín
  • Journal of Analytical Atomic Spectrometry, Vol. 32, Issue 9
  • DOI: 10.1039/C7JA00010C

Evolution of Collision/Reaction Cell Technology — Advent of Triple Quadrupole ICP-MS
journal, January 2018


Communication. Inductively coupled plasma as an ion source for high-resolution mass spectrometry
journal, January 1989

  • Bradshaw, Neil; Hall, Edward F. H.; Sanderson, Neil E.
  • Journal of Analytical Atomic Spectrometry, Vol. 4, Issue 8
  • DOI: 10.1039/ja9890400801

Sector field mass spectrometers in ICP-MS
journal, November 1998

  • Jakubowski, Norbert; Moens, Luc; Vanhaecke, Frank
  • Spectrochimica Acta Part B: Atomic Spectroscopy, Vol. 53, Issue 13
  • DOI: 10.1016/S0584-8547(98)00222-5

Isotope abundance ratio measurements by inductively coupled plasma-sector field mass spectrometry
journal, January 2012

  • Baxter, Douglas C.; Rodushkin, Ilia; Engström, Emma
  • Journal of Analytical Atomic Spectrometry, Vol. 27, Issue 9
  • DOI: 10.1039/c2ja30153a

High-Resolution Inductively Coupled Plasma Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
journal, September 1997

  • Milgram, K. Eric; White, Forest M.; Goodner, Kevin L.
  • Analytical Chemistry, Vol. 69, Issue 18
  • DOI: 10.1021/ac970126n

A Simple, Lensless Interface of an RF Glow Discharge Device to an FT-ICR (FTMS)
journal, September 1992

  • Marcus, R. Kenneth; Cable, Paula R.; Duckworth, Douglas C.
  • Applied Spectroscopy, Vol. 46, Issue 9
  • DOI: 10.1366/0003702924123683

The Orbitrap: a new mass spectrometer
journal, January 2005

  • Hu, Qizhi; Noll, Robert J.; Li, Hongyan
  • Journal of Mass Spectrometry, Vol. 40, Issue 4
  • DOI: 10.1002/jms.856

Mass Spectrometry-based Proteomics Using Q Exactive, a High-performance Benchtop Quadrupole Orbitrap Mass Spectrometer
journal, June 2011

  • Michalski, Annette; Damoc, Eugen; Hauschild, Jan-Peter
  • Molecular & Cellular Proteomics, Vol. 10, Issue 9
  • DOI: 10.1074/mcp.M111.011015

Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present
journal, July 2012

  • Bantscheff, Marcus; Lemeer, Simone; Savitski, Mikhail M.
  • Analytical and Bioanalytical Chemistry, Vol. 404, Issue 4
  • DOI: 10.1007/s00216-012-6203-4

Liquid Sampling-Atmospheric Pressure Glow Discharge Ionization Source for Elemental Mass Spectrometry
journal, April 2011

  • Marcus, R. Kenneth; Quarles, C. Derrick; Barinaga, Charles J.
  • Analytical Chemistry, Vol. 83, Issue 7
  • DOI: 10.1021/ac200098h

Liquid sampling–atmospheric pressure glow discharge (LS-APGD) ionization source for elemental mass spectrometry: preliminary parametric evaluation and figures of merit
journal, September 2011

  • Quarles, C. Derrick; Carado, Anthony J.; Barinaga, Charles J.
  • Analytical and Bioanalytical Chemistry, Vol. 402, Issue 1
  • DOI: 10.1007/s00216-011-5359-7

Atmospheric-pressure ionization and fragmentation of peptides by solution-cathode glow discharge
journal, January 2016

  • Schwartz, Andrew J.; Shelley, Jacob T.; Walton, Courtney L.
  • Chemical Science, Vol. 7, Issue 10
  • DOI: 10.1039/C6SC02032A

Atmospheric-pressure solution-cathode glow discharge: A versatile ion source for atomic and molecular mass spectrometry
journal, January 2017


Preliminary Figures of Merit for Isotope Ratio Measurements: The Liquid Sampling-Atmospheric Pressure Glow Discharge Microplasma Ionization Source Coupled to an Orbitrap Mass Analyzer
journal, April 2016

  • Hoegg, Edward D.; Barinaga, Charles J.; Hager, George J.
  • Journal of The American Society for Mass Spectrometry, Vol. 27, Issue 8
  • DOI: 10.1007/s13361-016-1402-4

Isotope ratio characteristics and sensitivity for uranium determinations using a liquid sampling-atmospheric pressure glow discharge ion source coupled to an Orbitrap mass analyzer
journal, January 2016

  • Hoegg, Edward D.; Barinaga, Charles J.; Hager, George J.
  • Journal of Analytical Atomic Spectrometry, Vol. 31, Issue 12
  • DOI: 10.1039/C6JA00163G

Concomitant ion effects on isotope ratio measurements with liquid sampling – atmospheric pressure glow discharge ion source Orbitrap mass spectrometry
journal, January 2018

  • Hoegg, Edward D.; Marcus, R. Kenneth; Hager, George J.
  • Journal of Analytical Atomic Spectrometry, Vol. 33, Issue 2
  • DOI: 10.1039/C7JA00308K

Initial Benchmarking of the Liquid Sampling-Atmospheric Pressure Glow Discharge-Orbitrap System Against Traditional Atomic Mass Spectrometry Techniques for Nuclear Applications
journal, October 2018

  • Hoegg, Edward D.; Manard, Benjamin T.; Wylie, E. Miller
  • Journal of The American Society for Mass Spectrometry, Vol. 30, Issue 2
  • DOI: 10.1007/s13361-018-2071-2

Determination of uranium isotope ratios using a liquid sampling atmospheric pressure glow discharge/Orbitrap mass spectrometer system
journal, August 2017

  • Hoegg, Edward D.; Marcus, R. Kenneth; Koppenaal, David W.
  • Rapid Communications in Mass Spectrometry, Vol. 31, Issue 18
  • DOI: 10.1002/rcm.7937

Principles and practice of electrospray ionization—mass spectrometry for large polypeptides and proteins
journal, September 1991

  • Smith, Richard D.; Loo, Joseph A.; Loo, Rachel R. Ogorzalek
  • Mass Spectrometry Reviews, Vol. 10, Issue 5
  • DOI: 10.1002/mas.1280100504

A novel ion funnel for focusing ions at elevated pressure using electrospray ionization mass spectrometry
journal, October 1997


Evaluation of the operating parameters of the liquid sampling-atmospheric pressure glow discharge (LS-APGD) ionization source for elemental mass spectrometry
journal, July 2014

  • Zhang, Lynn X.; Manard, Benjamin T.; Kappel, Stefanie Konegger
  • Analytical and Bioanalytical Chemistry, Vol. 406, Issue 29
  • DOI: 10.1007/s00216-014-7990-6

Mass spectra of diverse organic species utilizing the liquid sampling-atmospheric pressure glow discharge (LS-APGD) microplasma ionization source
journal, January 2016

  • Zhang, Lynn X.; Marcus, R. Kenneth
  • Journal of Analytical Atomic Spectrometry, Vol. 31, Issue 1
  • DOI: 10.1039/C5JA00376H

Liquid sampling-atmospheric pressure glow discharge (LS-APGD) microplasmas for diverse spectrochemical analysis applications
journal, January 2017

  • Marcus, R. Kenneth; Manard, Benjamin T.; Quarles, C. Derrick
  • Journal of Analytical Atomic Spectrometry, Vol. 32, Issue 4
  • DOI: 10.1039/C7JA00008A