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Title: Design and optimization of a fused-silica microfluidic device for separation of trivalent lanthanides by isotachophoresis

Abstract

Abstract Elemental analysis of rare earths is essential in a variety of fields including environmental monitoring and nuclear safeguards; however, current techniques are often labor intensive, time consuming and/or costly to perform. The difficulty arises in preparing samples, which requires separating the very chemically and physically similar lanthanides. However, by transitioning these separations to the microscale, the speed, cost, and simplicity of sample preparation can be drastically reduced. Here, all fourteen non radioactive lanthanides (lanthanum through lutetium minus promethium) are separated by ITP in a serpentine fused silica microchannel in < 10 minutes with limits of detection on the order of picomoles. Electrophoretic electrodes are embedded in the microchip reservoirs so that voltage can be quickly applied and switched during operation. The limits of detection are quantified using a commercial C4D to calculate ITP zone lengths in combination with ITP theory. Optimization of experimental procedures and reproducibility based on statistical analysis of subsequent experimental results are addressed.

Authors:
 [1];  [1];  [1];  [2]; ORCiD logo [1];  [1];  [1]
  1. BATTELLE (PACIFIC NW LAB)
  2. Washington State University
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1567273
Report Number(s):
PNNL-SA-138400
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Electrophoresis
Additional Journal Information:
Journal Volume: 40; Journal Issue: 18-19
Country of Publication:
United States
Language:
English

Citation Formats

Bottenus, Daniel R., Branch, Shirmir D., Lackey, Hope E., Ivory, Cornelius, Katalenich, Jeffrey A., Clark, Sue B., and Lines, Amanda M. Design and optimization of a fused-silica microfluidic device for separation of trivalent lanthanides by isotachophoresis. United States: N. p., 2019. Web. doi:10.1002/elps.201900027.
Bottenus, Daniel R., Branch, Shirmir D., Lackey, Hope E., Ivory, Cornelius, Katalenich, Jeffrey A., Clark, Sue B., & Lines, Amanda M. Design and optimization of a fused-silica microfluidic device for separation of trivalent lanthanides by isotachophoresis. United States. doi:10.1002/elps.201900027.
Bottenus, Daniel R., Branch, Shirmir D., Lackey, Hope E., Ivory, Cornelius, Katalenich, Jeffrey A., Clark, Sue B., and Lines, Amanda M. Mon . "Design and optimization of a fused-silica microfluidic device for separation of trivalent lanthanides by isotachophoresis". United States. doi:10.1002/elps.201900027.
@article{osti_1567273,
title = {Design and optimization of a fused-silica microfluidic device for separation of trivalent lanthanides by isotachophoresis},
author = {Bottenus, Daniel R. and Branch, Shirmir D. and Lackey, Hope E. and Ivory, Cornelius and Katalenich, Jeffrey A. and Clark, Sue B. and Lines, Amanda M.},
abstractNote = {Abstract Elemental analysis of rare earths is essential in a variety of fields including environmental monitoring and nuclear safeguards; however, current techniques are often labor intensive, time consuming and/or costly to perform. The difficulty arises in preparing samples, which requires separating the very chemically and physically similar lanthanides. However, by transitioning these separations to the microscale, the speed, cost, and simplicity of sample preparation can be drastically reduced. Here, all fourteen non radioactive lanthanides (lanthanum through lutetium minus promethium) are separated by ITP in a serpentine fused silica microchannel in < 10 minutes with limits of detection on the order of picomoles. Electrophoretic electrodes are embedded in the microchip reservoirs so that voltage can be quickly applied and switched during operation. The limits of detection are quantified using a commercial C4D to calculate ITP zone lengths in combination with ITP theory. Optimization of experimental procedures and reproducibility based on statistical analysis of subsequent experimental results are addressed.},
doi = {10.1002/elps.201900027},
journal = {Electrophoresis},
number = 18-19,
volume = 40,
place = {United States},
year = {2019},
month = {9}
}

Works referenced in this record:

Factors affecting the separation of inorganic metal cations by capillary electrophoresis
journal, February 1992

  • Weston, Andrea; Brown, Phyllis R.; Jandik, Petr
  • Journal of Chromatography A, Vol. 593, Issue 1-2, p. 289-295
  • DOI: 10.1016/0021-9673(92)80297-8