skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural basis of tubulin detyrosination by vasohibins

; ; ; ;  [1]
  1. UTSMC
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
OSTI Identifier:
Resource Type:
Journal Article
Journal Name:
Nat. Struct. Mol. Biol.
Additional Journal Information:
Journal Volume: 26; Journal Issue: 07, 2019
Country of Publication:
United States

Citation Formats

Li, Faxiang, Hu, Yingjie, Qi, Shutao, Luo, Xuelian, and Yu, Hongtao. Structural basis of tubulin detyrosination by vasohibins. United States: N. p., 2019. Web. doi:10.1038/s41594-019-0242-x.
Li, Faxiang, Hu, Yingjie, Qi, Shutao, Luo, Xuelian, & Yu, Hongtao. Structural basis of tubulin detyrosination by vasohibins. United States. doi:10.1038/s41594-019-0242-x.
Li, Faxiang, Hu, Yingjie, Qi, Shutao, Luo, Xuelian, and Yu, Hongtao. Wed . "Structural basis of tubulin detyrosination by vasohibins". United States. doi:10.1038/s41594-019-0242-x.
title = {Structural basis of tubulin detyrosination by vasohibins},
author = {Li, Faxiang and Hu, Yingjie and Qi, Shutao and Luo, Xuelian and Yu, Hongtao},
abstractNote = {},
doi = {10.1038/s41594-019-0242-x},
journal = {Nat. Struct. Mol. Biol.},
number = 07, 2019,
volume = 26,
place = {United States},
year = {2019},
month = {9}

Works referenced in this record:

Actin–microtubule crosstalk in cell biology
journal, October 2018

  • Dogterom, Marileen; Koenderink, Gijsje H.
  • Nature Reviews Molecular Cell Biology, Vol. 20, Issue 1
  • DOI: 10.1038/s41580-018-0067-1

Dynamic instability of microtubule growth
journal, November 1984

  • Mitchison, Tim; Kirschner, Marc
  • Nature, Vol. 312, Issue 5991
  • DOI: 10.1038/312237a0

Microtubule Polymerization Dynamics
journal, November 1997

Microtubule dynamics: an interplay of biochemistry and mechanics
journal, April 2018

Post-translational modifications of tubulin: pathways to functional diversity of microtubules
journal, March 2015

The tubulin code at a glance
journal, March 2017

  • Gadadhar, Sudarshan; Bodakuntla, Satish; Natarajan, Kathiresan
  • Journal of Cell Science, Vol. 130, Issue 8
  • DOI: 10.1242/jcs.199471

Tubulin Posttranslational Modifications and Emerging Links to Human Disease
journal, May 2018

SnapShot: Functions of Tubulin Posttranslational Modifications
journal, May 2018

The Tubulin Detyrosination Cycle: Function and Enzymes
journal, January 2019

Incorporation of l-Tyrosine, l-Phenylalanine and l-3,4-Dihydroxyphenylalanine as Single Units into Rat Brain Tubulin
journal, November 1975

An enzyme tyrosylating α-tubulin and its role in microtubule assembly
journal, August 1975

Release of tyrosine from tyrosinated tubulin. Some common factors that affect this process and the assembly of tubulin
journal, February 1977

Characterization of the tubulin-tyrosine ligase
journal, February 1993

Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin
journal, October 2011

  • Szyk, Agnieszka; Deaconescu, Alexandra M.; Piszczek, Grzegorz
  • Nature Structural & Molecular Biology, Vol. 18, Issue 11
  • DOI: 10.1038/nsmb.2148

Release of C-terminal tyrosine from tubulin and microtubules at steady state
journal, February 1985

  • Arce, C. A.; Barra, H. S.
  • Biochemical Journal, Vol. 226, Issue 1
  • DOI: 10.1042/bj2260311

Postpolymerization detyrosination of alpha-tubulin: a mechanism for subcellular differentiation of microtubules
journal, July 1987

Capturing protein tails by CAP-Gly domains
journal, November 2008

A vital role of tubulin-tyrosine-ligase for neuronal organization
journal, May 2005

  • Erck, C.; Peris, L.; Andrieux, A.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 22
  • DOI: 10.1073/pnas.0409626102

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle
journal, October 2015

  • Kerr, Jaclyn P.; Robison, Patrick; Shi, Guoli
  • Nature Communications, Vol. 6, Issue 1
  • DOI: 10.1038/ncomms9526

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes
journal, April 2016

Microtubule detyrosination guides chromosomes during mitosis
journal, April 2015

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation
journal, November 2017

Vasohibins encode tubulin detyrosinating activity
journal, November 2017

  • Nieuwenhuis, Joppe; Adamopoulos, Athanassios; Bleijerveld, Onno B.
  • Science, Vol. 358, Issue 6369
  • DOI: 10.1126/science.aao5676

Loss of function of SVBP leads to autosomal recessive intellectual disability, microcephaly, ataxia, and hypotonia
journal, January 2019

Parthenolide Inhibits Tubulin Carboxypeptidase Activity
journal, April 2007

Structural Characterization of a Conserved, Calcium-Dependent Periplasmic Protease from Legionella pneumophila
journal, June 2012

  • Chatterjee, D.; Boyd, C. D.; O'Toole, G. A.
  • Journal of Bacteriology, Vol. 194, Issue 16
  • DOI: 10.1128/JB.00640-12

Vasohibins: new transglutaminase-like cysteine proteases possessing a non-canonical Cys-His-Ser catalytic triad
journal, January 2016

Parthenolide Modulates the NF-κB–Mediated Inflammatory Responses in Experimental Atherosclerosis
journal, August 2006

  • López-Franco, Oscar; Hernández-Vargas, Purificación; Ortiz-Muñoz, Guadalupe
  • Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 26, Issue 8
  • DOI: 10.1161/01.ATV.0000229659.94020.53

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
journal, June 2005

Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells
journal, March 2016

  • Duan, Dongzhu; Zhang, Junmin; Yao, Juan
  • Journal of Biological Chemistry, Vol. 291, Issue 19
  • DOI: 10.1074/jbc.M115.700591

HKL -3000: the integration of data reduction and structure solution – from diffraction images to an initial model in minutes
journal, July 2006

  • Minor, Wladek; Cymborowski, Marcin; Otwinowski, Zbyszek
  • Acta Crystallographica Section D Biological Crystallography, Vol. 62, Issue 8
  • DOI: 10.1107/S0907444906019949

PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

Features and development of Coot
journal, March 2010

  • Emsley, P.; Lohkamp, B.; Scott, W. G.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
  • DOI: 10.1107/S0907444910007493

Solving structures of protein complexes by molecular replacement with Phaser
journal, December 2006

  • McCoy, Airlie J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 63, Issue 1
  • DOI: 10.1107/S0907444906045975

MolProbity : all-atom structure validation for macromolecular crystallography
journal, December 2009

  • Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1
  • DOI: 10.1107/S0907444909042073

Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends
journal, April 2016