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Title: Topological control of cytokine receptor signaling induces differential effects in hematopoiesis

Authors:
; ; ; ; ; ; ; ; ; ; ; ;  [1]
  1. UWASH
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1561300
Resource Type:
Journal Article
Journal Name:
Science
Additional Journal Information:
Journal Volume: 364; Journal Issue: 05, 2019
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Mohan, Kritika, Ueda, George, Kim, Ah Ram, Jude, Kevin M., Fallas, Jorge A., Guo, Yu, Hafer, Maximillian, Miao, Yi, Saxton, Robert A., Piehler, Jacob, Sankaran, Vijay G., Baker, David, Garcia, K. Christopher, Stanford-MED), Osnabruck), BCH), and Nankai). Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. United States: N. p., 2019. Web. doi:10.1126/science.aav7532.
Mohan, Kritika, Ueda, George, Kim, Ah Ram, Jude, Kevin M., Fallas, Jorge A., Guo, Yu, Hafer, Maximillian, Miao, Yi, Saxton, Robert A., Piehler, Jacob, Sankaran, Vijay G., Baker, David, Garcia, K. Christopher, Stanford-MED), Osnabruck), BCH), & Nankai). Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. United States. doi:10.1126/science.aav7532.
Mohan, Kritika, Ueda, George, Kim, Ah Ram, Jude, Kevin M., Fallas, Jorge A., Guo, Yu, Hafer, Maximillian, Miao, Yi, Saxton, Robert A., Piehler, Jacob, Sankaran, Vijay G., Baker, David, Garcia, K. Christopher, Stanford-MED), Osnabruck), BCH), and Nankai). Tue . "Topological control of cytokine receptor signaling induces differential effects in hematopoiesis". United States. doi:10.1126/science.aav7532.
@article{osti_1561300,
title = {Topological control of cytokine receptor signaling induces differential effects in hematopoiesis},
author = {Mohan, Kritika and Ueda, George and Kim, Ah Ram and Jude, Kevin M. and Fallas, Jorge A. and Guo, Yu and Hafer, Maximillian and Miao, Yi and Saxton, Robert A. and Piehler, Jacob and Sankaran, Vijay G. and Baker, David and Garcia, K. Christopher and Stanford-MED) and Osnabruck) and BCH) and Nankai)},
abstractNote = {},
doi = {10.1126/science.aav7532},
journal = {Science},
number = 05, 2019,
volume = 364,
place = {United States},
year = {2019},
month = {9}
}

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    Works referencing / citing this record:

    Selecting Agonists from Single Cells Infected with Combinatorial Antibody Libraries
    journal, May 2013


    Apoptotic mechanisms in the control of erythropoiesis
    journal, June 2004


    Robust single-particle tracking in live-cell time-lapse sequences
    journal, July 2008

    • Jaqaman, Khuloud; Loerke, Dinah; Mettlen, Marcel
    • Nature Methods, Vol. 5, Issue 8
    • DOI: 10.1038/nmeth.1237

    Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes
    journal, July 2008

    • Sergé, Arnauld; Bertaux, Nicolas; Rigneault, Hervé
    • Nature Methods, Vol. 5, Issue 8
    • DOI: 10.1038/nmeth.1233

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    journal, August 2011


    Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling
    journal, May 2015

    • Wilmes, Stephan; Beutel, Oliver; Li, Zhi
    • The Journal of Cell Biology, Vol. 209, Issue 4
    • DOI: 10.1083/jcb.201412049

    Efficiency of signalling through cytokine receptors depends critically on receptor orientation
    journal, October 1998

    • Syed, Rashid S.; Reid, Scott W.; Li, Cuiwei
    • Nature, Vol. 395, Issue 6701
    • DOI: 10.1038/26773

    Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor
    journal, December 2007

    • Kai, Masayuki; Motoki, Kazuhiro; Yoshida, Hideaki
    • Nature Biotechnology, Vol. 26, Issue 2
    • DOI: 10.1038/nbt1376

    Rapid Transfer of Transmembrane Proteins for Single Molecule Dimerization Assays in Polymer-Supported Membranes
    journal, September 2014

    • Roder, Friedrich; Wilmes, Stephan; Richter, Christian P.
    • ACS Chemical Biology, Vol. 9, Issue 11
    • DOI: 10.1021/cb5005806

    Insights into Cytokine–Receptor Interactions from Cytokine Engineering
    journal, March 2015


    Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands
    journal, March 2015


    Isolating and engineering human antibodies using yeast surface display
    journal, July 2006

    • Chao, Ginger; Lau, Wai L.; Hackel, Benjamin J.
    • Nature Protocols, Vol. 1, Issue 2
    • DOI: 10.1038/nprot.2006.94

    Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 A
    journal, July 1996


    IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance
    journal, December 2011


    An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway
    journal, May 2008

    • Rowlinson, Scott W.; Yoshizato, Hideo; Barclay, Johanna L.
    • Nature Cell Biology, Vol. 10, Issue 6
    • DOI: 10.1038/ncb1737

    Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy
    journal, January 2015


    Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases
    journal, October 2016

    • Akdis, Mübeccel; Aab, Alar; Altunbulakli, Can
    • Journal of Allergy and Clinical Immunology, Vol. 138, Issue 4
    • DOI: 10.1016/j.jaci.2016.06.033

    Interpreting mixed signals: the cell's cytokine conundrum
    journal, October 2011

    • Delgoffe, Greg M.; Murray, Peter J.; Vignali, Dario AA
    • Current Opinion in Immunology, Vol. 23, Issue 5
    • DOI: 10.1016/j.coi.2011.07.013

    Dimerization of the Erythropoietin Receptor Transmembrane Domain in Micelles
    journal, February 2007


    Computational design of self-assembling cyclic protein homo-oligomers
    journal, December 2016

    • Fallas, Jorge A.; Ueda, George; Sheffler, William
    • Nature Chemistry, Vol. 9, Issue 4
    • DOI: 10.1038/nchem.2673

    Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps
    journal, May 2015


    Hematopoietic cytokines
    journal, January 2008


    Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
    journal, March 2018

    • Sockolosky, Jonathan T.; Trotta, Eleonora; Parisi, Giulia
    • Science, Vol. 359, Issue 6379
    • DOI: 10.1126/science.aar3246

    Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells
    journal, January 2016


    Recent developments in biased agonism
    journal, April 2014


    Ankyrin Repeat:  A Unique Motif Mediating Protein−Protein Interactions
    journal, December 2006

    • Li, Junan; Mahajan, Anjali; Tsai, Ming-Daw
    • Biochemistry, Vol. 45, Issue 51
    • DOI: 10.1021/bi062188q

    From DARPins to LoopDARPins: Novel LoopDARPin Design Allows the Selection of Low Picomolar Binders in a Single Round of Ribosome Display
    journal, February 2014

    • Schilling, Johannes; Schöppe, Jendrik; Plückthun, Andreas
    • Journal of Molecular Biology, Vol. 426, Issue 3
    • DOI: 10.1016/j.jmb.2013.10.026

    Mechanistic Diversity of Cytokine Receptor Signaling Across Cell Membranes
    journal, April 2004


    Will any dimer do?
    journal, November 1998

    • Ballinger, Marcus D.; Wells, James A.
    • Nature Structural Biology, Vol. 5, Issue 11
    • DOI: 10.1038/2911

    Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation
    journal, March 2017


    High-affinity binders selected from designed ankyrin repeat protein libraries
    journal, April 2004

    • Binz, H. Kaspar; Amstutz, Patrick; Kohl, Andreas
    • Nature Biotechnology, Vol. 22, Issue 5, p. 575-582
    • DOI: 10.1038/nbt962

    A Reducing and Oxidizing System Minimizes Photobleaching and Blinking of Fluorescent Dyes
    journal, July 2008

    • Vogelsang, Jan; Kasper, Robert; Steinhauer, Christian
    • Angewandte Chemie International Edition, Vol. 47, Issue 29, p. 5465-5469
    • DOI: 10.1002/anie.200801518

    X-Ray Diffraction data from dimeric DARPin E2C, source of 6MOG structure
    dataset, January 2019


    Orientation-specific signalling by thrombopoietin receptor dimers: Orientation-specific TpoR signalling
    journal, September 2011

    • Staerk, Judith; Defour, Jean-Philippe; Pecquet, Christian
    • The EMBO Journal, Vol. 30, Issue 21
    • DOI: 10.1038/emboj.2011.315

    EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics
    journal, October 2017


    Effective screening method of agonistic diabodies based on autocrine growth
    journal, August 2009

    • Nakano, Kiyotaka; Kojima, Tetsuo; Kasutani, Keiko
    • Journal of Immunological Methods, Vol. 347, Issue 1-2
    • DOI: 10.1016/j.jim.2009.05.012

    Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling
    journal, March 2017


    Cell Signaling by Receptor Tyrosine Kinases
    journal, June 2010