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Title: Structural and functional consequences of the STAT5B[superscript N642H] driver mutation

Authors:
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  1. DFCI
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
FOREIGN
OSTI Identifier:
1560094
Resource Type:
Journal Article
Journal Name:
Nat. Commun.
Additional Journal Information:
Journal Volume: 10; Journal Issue: 2019
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

de Araujo, Elvin D., Erdogan, Fettah, Neubauer, Heidi A., Meneksedag-Erol, Deniz, Manaswiyoungkul, Pimyupa, Eram, Mohammad S., Seo, Hyuk-Soo, Qadree, Abdul K., Israelian, Johan, Orlova, Anna, Suske, Tobias, Pham, Ha T.T., Boersma, Auke, Tangermann, Simone, Kenner, Lukas, Rülicke, Thomas, Dong, Aiping, Ravichandran, Manimekalai, Brown, Peter J., Audette, Gerald F., Rauscher, Sarah, Dhe-Paganon, Sirano, Moriggl, Richard, Gunning, Patrick T., U. Vet. Med.), Toronto), and York). Structural and functional consequences of the STAT5B[superscript N642H] driver mutation. United States: N. p., 2019. Web. doi:10.1038/s41467-019-10422-7.
de Araujo, Elvin D., Erdogan, Fettah, Neubauer, Heidi A., Meneksedag-Erol, Deniz, Manaswiyoungkul, Pimyupa, Eram, Mohammad S., Seo, Hyuk-Soo, Qadree, Abdul K., Israelian, Johan, Orlova, Anna, Suske, Tobias, Pham, Ha T.T., Boersma, Auke, Tangermann, Simone, Kenner, Lukas, Rülicke, Thomas, Dong, Aiping, Ravichandran, Manimekalai, Brown, Peter J., Audette, Gerald F., Rauscher, Sarah, Dhe-Paganon, Sirano, Moriggl, Richard, Gunning, Patrick T., U. Vet. Med.), Toronto), & York). Structural and functional consequences of the STAT5B[superscript N642H] driver mutation. United States. doi:10.1038/s41467-019-10422-7.
de Araujo, Elvin D., Erdogan, Fettah, Neubauer, Heidi A., Meneksedag-Erol, Deniz, Manaswiyoungkul, Pimyupa, Eram, Mohammad S., Seo, Hyuk-Soo, Qadree, Abdul K., Israelian, Johan, Orlova, Anna, Suske, Tobias, Pham, Ha T.T., Boersma, Auke, Tangermann, Simone, Kenner, Lukas, Rülicke, Thomas, Dong, Aiping, Ravichandran, Manimekalai, Brown, Peter J., Audette, Gerald F., Rauscher, Sarah, Dhe-Paganon, Sirano, Moriggl, Richard, Gunning, Patrick T., U. Vet. Med.), Toronto), and York). Tue . "Structural and functional consequences of the STAT5B[superscript N642H] driver mutation". United States. doi:10.1038/s41467-019-10422-7.
@article{osti_1560094,
title = {Structural and functional consequences of the STAT5B[superscript N642H] driver mutation},
author = {de Araujo, Elvin D. and Erdogan, Fettah and Neubauer, Heidi A. and Meneksedag-Erol, Deniz and Manaswiyoungkul, Pimyupa and Eram, Mohammad S. and Seo, Hyuk-Soo and Qadree, Abdul K. and Israelian, Johan and Orlova, Anna and Suske, Tobias and Pham, Ha T.T. and Boersma, Auke and Tangermann, Simone and Kenner, Lukas and Rülicke, Thomas and Dong, Aiping and Ravichandran, Manimekalai and Brown, Peter J. and Audette, Gerald F. and Rauscher, Sarah and Dhe-Paganon, Sirano and Moriggl, Richard and Gunning, Patrick T. and U. Vet. Med.) and Toronto) and York)},
abstractNote = {},
doi = {10.1038/s41467-019-10422-7},
journal = {Nat. Commun.},
number = 2019,
volume = 10,
place = {United States},
year = {2019},
month = {9}
}

Works referenced in this record:

The JAK-STAT Pathway at Twenty
journal, April 2012


Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B
journal, March 2008

  • Hennighausen, L.; Robinson, G. W.
  • Genes & Development, Vol. 22, Issue 6
  • DOI: 10.1101/gad.1643908

STATs get their move on
journal, October 2013


Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome
journal, May 2017

  • Schwartzman, Omer; Savino, Angela Maria; Gombert, Michael
  • Proceedings of the National Academy of Sciences, Vol. 114, Issue 20
  • DOI: 10.1073/pnas.1702489114

STAT5BN642H is a driver mutation for T cell neoplasia
journal, December 2017

  • Pham, Ha Thi Thanh; Maurer, Barbara; Prchal-Murphy, Michaela
  • Journal of Clinical Investigation, Vol. 128, Issue 1
  • DOI: 10.1172/JCI94509

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia
journal, February 2014


Disorders of the JAK/STAT Pathway in T Cell Lymphoma Pathogenesis: Implications for Immunotherapy
journal, April 2017


BCR-ABL Affects STAT5A and STAT5B Differentially
journal, May 2014


Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia
journal, January 2019


STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression
journal, October 2007

  • Zhang, Qian; Wang, Hong Y.; Liu, Xiaobin
  • Nature Medicine, Vol. 13, Issue 11
  • DOI: 10.1038/nm1659

Prognostic significance of signal transducer and activator of transcription 5 and 5b expression in Epstein-Barr virus-positive patients with chronic lymphocytic leukemia
journal, July 2016

  • Diamantopoulos, Panagiotis T.; Sofotasiou, Maria; Georgoussi, Zafiroula
  • Cancer Medicine, Vol. 5, Issue 9
  • DOI: 10.1002/cam4.804

Stat5 Synergizes with T Cell Receptor/Antigen Stimulation in the Development of Lymphoblastic Lymphoma
journal, June 2003

  • Kelly, John A.; Spolski, Rosanne; Kovanen, Panu E.
  • The Journal of Experimental Medicine, Vol. 198, Issue 1
  • DOI: 10.1084/jem.20021548

Molecular Insights Into Pathogenesis of Peripheral T Cell Lymphoma: a Review
journal, June 2018

  • Lone, Waseem; Alkhiniji, Aisha; Manikkam Umakanthan, Jayadev
  • Current Hematologic Malignancy Reports, Vol. 13, Issue 4
  • DOI: 10.1007/s11899-018-0460-z

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
journal, June 2009

  • Buonamici, Silvia; Trimarchi, Thomas; Ruocco, Maria Grazia
  • Nature, Vol. 459, Issue 7249
  • DOI: 10.1038/nature08020

Primary CNS T-cell Lymphomas: A Clinical, Morphologic, Immunophenotypic, and Molecular Analysis
journal, January 2015

  • Menon, Madhu P.; Nicolae, Alina; Meeker, Hillary
  • The American Journal of Surgical Pathology, Vol. 39, Issue 12
  • DOI: 10.1097/PAS.0000000000000503

High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia
journal, November 2016


<i>STAT3</i> mutation impacts biological and clinical features of T-LGL leukemia
journal, June 2017


Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia
journal, May 2013


High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia
journal, January 2008


Frequent STAT5B mutations in γδ hepatosplenic T-cell lymphomas
journal, June 2014


Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization
journal, October 2016

  • Fahrenkamp, Dirk; Li, Jinyu; Ernst, Sabrina
  • Scientific Reports, Vol. 6, Issue 1
  • DOI: 10.1038/srep35454

Structure of the Unphosphorylated STAT5a Dimer
journal, September 2005

  • Neculai, Dante; Neculai, Ana Mirela; Verrier, Sophie
  • Journal of Biological Chemistry, Vol. 280, Issue 49
  • DOI: 10.1074/jbc.M507682200

Crystal structure of unphosphorylated STAT3 core fragment
journal, September 2008

  • Ren, Zhiyong; Mao, Xiang; Mertens, Claudia
  • Biochemical and Biophysical Research Communications, Vol. 374, Issue 1
  • DOI: 10.1016/j.bbrc.2008.04.049

Structural Bases of Unphosphorylated STAT1 Association and Receptor Binding
journal, March 2005


Identification of the Linker-SH2 Domain of STAT as the Origin of the SH2 Domain Using Two-dimensional Structural Alignment
journal, April 2004


The language of SH2 domain interactions defines phosphotyrosine-mediated signal transduction
journal, May 2012


A functional in vitro assay for screening inhibitors of STAT5B phosphorylation
journal, January 2019

  • de Araujo, Elvin D.; Manaswiyoungkul, Pimyupa; Erdogan, Fettah
  • Journal of Pharmaceutical and Biomedical Analysis, Vol. 162
  • DOI: 10.1016/j.jpba.2018.08.036

Purification and identification of the STAT5 protease in myeloid cells
journal, April 2007

  • Schuster, Björn; Hendry, Lisa; Byers, Helen
  • Biochemical Journal, Vol. 404, Issue 1
  • DOI: 10.1042/BJ20061877

Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia
journal, August 2014


Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia
journal, February 2016

  • López, Cristina; Bergmann, Anke K.; Paul, Ulrike
  • British Journal of Haematology, Vol. 173, Issue 2
  • DOI: 10.1111/bjh.13952

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling
journal, August 2017


Comprehensive Analysis of Transcriptome Variation Uncovers Known and Novel Driver Events in T-Cell Acute Lymphoblastic Leukemia
journal, December 2013


Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors
journal, June 2016


Identification of Gene Mutations and Fusion Genes in Patients with Sézary Syndrome
journal, July 2016

  • Prasad, Aparna; Rabionet, Raquel; Espinet, Blanca
  • Journal of Investigative Dermatology, Vol. 136, Issue 7
  • DOI: 10.1016/j.jid.2016.03.024

Rare occurrence of a STAT5B N642H mutation in adult T-cell acute lymphoblastic leukemia
journal, January 2015


Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations
journal, September 2016

  • Roberti, Annalisa; Dobay, Maria Pamela; Bisig, Bettina
  • Nature Communications, Vol. 7, Issue 1
  • DOI: 10.1038/ncomms12602

Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia
journal, December 2018


Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma
journal, November 2015


Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
journal, July 2015

  • Jiang, Lu; Gu, Zhao-Hui; Yan, Zi-Xun
  • Nature Genetics, Vol. 47, Issue 9
  • DOI: 10.1038/ng.3358

Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia
journal, April 2015


ONCOMINE: A Cancer Microarray Database and Integrated Data-Mining Platform
journal, January 2004


Strategies for over-expression and purification of recombinant full length STAT5B in Escherichia coli
journal, January 2017

  • de Araujo, Elvin D.; Geletu, Mulu; Gunning, Patrick T.
  • Protein Expression and Purification, Vol. 129
  • DOI: 10.1016/j.pep.2016.08.017

Tandem SUMO fusion vectors for improving soluble protein expression and purification
journal, December 2015

  • Guerrero, Fernando; Ciragan, Annika; Iwaï, Hideo
  • Protein Expression and Purification, Vol. 116
  • DOI: 10.1016/j.pep.2015.08.019

xia2 : an expert system for macromolecular crystallography data reduction
journal, December 2009


Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206

Towards automated crystallographic structure refinement with phenix.refine
journal, March 2012

  • Afonine, Pavel V.; Grosse-Kunstleve, Ralf W.; Echols, Nathaniel
  • Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 4
  • DOI: 10.1107/S0907444912001308

Use of knowledge-based restraints in phenix.refine to improve macromolecular refinement at low resolution
journal, March 2012

  • Headd, Jeffrey J.; Echols, Nathaniel; Afonine, Pavel V.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 4
  • DOI: 10.1107/S0907444911047834

Bulk-solvent and overall scaling revisited: faster calculations, improved results
journal, March 2013

  • Afonine, P. V.; Grosse-Kunstleve, R. W.; Adams, P. D.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 69, Issue 4
  • DOI: 10.1107/S0907444913000462

Automatic multiple-zone rigid-body refinement with a large convergence radius
journal, July 2009

  • Afonine, Pavel V.; Grosse-Kunstleve, Ralf W.; Urzhumtsev, Alexandre
  • Journal of Applied Crystallography, Vol. 42, Issue 4
  • DOI: 10.1107/S0021889809023528

Features and development of Coot
journal, March 2010

  • Emsley, P.; Lohkamp, B.; Scott, W. G.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
  • DOI: 10.1107/S0907444910007493

MolProbity : all-atom structure validation for macromolecular crystallography
journal, December 2009

  • Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1
  • DOI: 10.1107/S0907444909042073

UCSF Chimera?A visualization system for exploratory research and analysis
journal, January 2004

  • Pettersen, Eric F.; Goddard, Thomas D.; Huang, Conrad C.
  • Journal of Computational Chemistry, Vol. 25, Issue 13
  • DOI: 10.1002/jcc.20084

SWISS-MODEL and the Swiss-Pdb Viewer: An environment for comparative protein modeling
journal, January 1997


Modeling of loops in protein structures
journal, January 2000

  • Fiser, András; Do, Richard Kinh Gian; Šali, Andrej
  • Protein Science, Vol. 9, Issue 9
  • DOI: 10.1110/ps.9.9.1753

All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins
journal, April 1998

  • MacKerell, A. D.; Bashford, D.; Bellott, M.
  • The Journal of Physical Chemistry B, Vol. 102, Issue 18
  • DOI: 10.1021/jp973084f

GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers
journal, September 2015


Improving efficiency of large time-scale molecular dynamics simulations of hydrogen-rich systems
journal, June 1999


A smooth particle mesh Ewald method
journal, November 1995

  • Essmann, Ulrich; Perera, Lalith; Berkowitz, Max L.
  • The Journal of Chemical Physics, Vol. 103, Issue 19
  • DOI: 10.1063/1.470117

LINCS: A linear constraint solver for molecular simulations
journal, September 1997


Settle: An analytical version of the SHAKE and RATTLE algorithm for rigid water models
journal, October 1992

  • Miyamoto, Shuichi; Kollman, Peter A.
  • Journal of Computational Chemistry, Vol. 13, Issue 8
  • DOI: 10.1002/jcc.540130805

Molecular dynamics with coupling to an external bath
journal, October 1984

  • Berendsen, H. J. C.; Postma, J. P. M.; van Gunsteren, W. F.
  • The Journal of Chemical Physics, Vol. 81, Issue 8
  • DOI: 10.1063/1.448118

Polymorphic transitions in single crystals: A new molecular dynamics method
journal, December 1981

  • Parrinello, M.; Rahman, A.
  • Journal of Applied Physics, Vol. 52, Issue 12
  • DOI: 10.1063/1.328693

CHARMM36m: an improved force field for folded and intrinsically disordered proteins
journal, November 2016

  • Huang, Jing; Rauscher, Sarah; Nawrocki, Grzegorz
  • Nature Methods, Vol. 14, Issue 1
  • DOI: 10.1038/nmeth.4067

VMD: Visual molecular dynamics
journal, February 1996