skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe

Authors:
; ; ; ; ; ; ; ; ; ; ;  [1]
  1. Michigan
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1557319
Resource Type:
Journal Article
Journal Name:
Proc. Natl. Acad. Sci. USA
Additional Journal Information:
Journal Volume: 116; Journal Issue: (32) ; 08, 2019
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Beyett, Tyler S., Fraley, Amy E., Labudde, Emily, Patra, Dhabaleswar, Coleman, Ryan C., Eguchi, Akito, Glukhova, Alisa, Chen, Qiuyan, Williams, Robert M., Koch, Walter J., Sherman, David H., Tesmer, John J.G., Purdue), CSU), and Temple). Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. United States: N. p., 2019. Web. doi:10.1073/pnas.1818547116.
Beyett, Tyler S., Fraley, Amy E., Labudde, Emily, Patra, Dhabaleswar, Coleman, Ryan C., Eguchi, Akito, Glukhova, Alisa, Chen, Qiuyan, Williams, Robert M., Koch, Walter J., Sherman, David H., Tesmer, John J.G., Purdue), CSU), & Temple). Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. United States. doi:10.1073/pnas.1818547116.
Beyett, Tyler S., Fraley, Amy E., Labudde, Emily, Patra, Dhabaleswar, Coleman, Ryan C., Eguchi, Akito, Glukhova, Alisa, Chen, Qiuyan, Williams, Robert M., Koch, Walter J., Sherman, David H., Tesmer, John J.G., Purdue), CSU), and Temple). Thu . "Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe". United States. doi:10.1073/pnas.1818547116.
@article{osti_1557319,
title = {Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe},
author = {Beyett, Tyler S. and Fraley, Amy E. and Labudde, Emily and Patra, Dhabaleswar and Coleman, Ryan C. and Eguchi, Akito and Glukhova, Alisa and Chen, Qiuyan and Williams, Robert M. and Koch, Walter J. and Sherman, David H. and Tesmer, John J.G. and Purdue) and CSU) and Temple)},
abstractNote = {},
doi = {10.1073/pnas.1818547116},
journal = {Proc. Natl. Acad. Sci. USA},
number = (32) ; 08, 2019,
volume = 116,
place = {United States},
year = {2019},
month = {10}
}

Works referenced in this record:

Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes
journal, April 2016

  • Tesmer, John J. G.
  • Nature Reviews Molecular Cell Biology, Vol. 17, Issue 7
  • DOI: 10.1038/nrm.2016.36

G protein-coupled receptor kinases: Past, present and future
journal, January 2018


Inhibition of G Protein-coupled Receptor Kinase Subtypes by Ca 2+ /Calmodulin
journal, November 1996

  • Chuang, Tsu Tshen; Paolucci, Lina; De Blasi, Antonio
  • Journal of Biological Chemistry, Vol. 271, Issue 45
  • DOI: 10.1074/jbc.271.45.28691

Regulation of G Protein-coupled Receptor Kinases by Calmodulin and Localization of the Calmodulin Binding Domain
journal, July 1997

  • Pronin, Alexey N.; Satpaev, Daulet K.; Slepak, Vladlen Z.
  • Journal of Biological Chemistry, Vol. 272, Issue 29
  • DOI: 10.1074/jbc.272.29.18273

Localization of the Sites for Ca 2+ -Binding Proteins on G Protein-Coupled Receptor Kinases
journal, September 1998

  • Levay, Konstantin; Satpaev, Daulet K.; Pronin, Alexey N.
  • Biochemistry, Vol. 37, Issue 39
  • DOI: 10.1021/bi980998z

Regulation of G-protein-coupled receptor kinase subtypes by calcium sensor proteins
journal, January 1999

  • Iacovelli, Luisa; Sallese, Michele; Mariggiò, Stefania
  • The FASEB Journal, Vol. 13, Issue 1
  • DOI: 10.1096/fasebj.13.1.1

Prevalence of left-ventricular hypertrophy in hypertension: an updated review of echocardiographic studies
journal, November 2011

  • Cuspidi, C.; Sala, C.; Negri, F.
  • Journal of Human Hypertension, Vol. 26, Issue 6
  • DOI: 10.1038/jhh.2011.104

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes
journal, August 2008

  • Martini, J. S.; Raake, P.; Vinge, L. E.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 34
  • DOI: 10.1073/pnas.0803153105

GRK5-Mediated Exacerbation of Pathological Cardiac Hypertrophy Involves Facilitation of Nuclear NFAT Activity
journal, December 2014

  • Hullmann, Jonathan E.; Grisanti, Laurel A.; Makarewich, Catherine A.
  • Circulation Research, Vol. 115, Issue 12
  • DOI: 10.1161/CIRCRESAHA.116.304475

The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors
journal, March 2018

  • Sorriento, Daniela; Santulli, Gaetano; Ciccarelli, Michele
  • International Journal of Molecular Sciences, Vol. 19, Issue 3
  • DOI: 10.3390/ijms19030861

The Evolving Impact of G Protein-Coupled Receptor Kinases in Cardiac Health and Disease
journal, April 2015


Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases
journal, June 2015

  • Komolov, Konstantin E.; Bhardwaj, Anshul; Benovic, Jeffrey L.
  • Journal of Biological Chemistry, Vol. 290, Issue 34
  • DOI: 10.1074/jbc.M115.647297

Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor
journal, June 2015

  • Homan, Kristoff T.; Waldschmidt, Helen V.; Glukhova, Alisa
  • Journal of Biological Chemistry, Vol. 290, Issue 34
  • DOI: 10.1074/jbc.M115.647370

Malbrancheamide, a new calmodulin inhibitor from the fungus Malbranchea aurantiaca
journal, February 2006


Fluorescence, circular dichroism, NMR, and docking studies of the interaction of the alkaloid malbrancheamide with calmodulin
journal, October 2010

  • Figueroa, Mario; González-Andrade, Martín; Sosa-Peinado, Alejandro
  • Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 26, Issue 3
  • DOI: 10.3109/14756366.2010.518964

Insights into molecular interactions between CaM and its inhibitors from molecular dynamics simulations and experimental data
journal, February 2015

  • González-Andrade, Martin; Rodríguez-Sotres, Rogelio; Madariaga-Mazón, Abraham
  • Journal of Biomolecular Structure and Dynamics, Vol. 34, Issue 1
  • DOI: 10.1080/07391102.2015.1022225

Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law
journal, April 2011

  • Rambo, Robert P.; Tainer, John A.
  • Biopolymers, Vol. 95, Issue 8
  • DOI: 10.1002/bip.21638

Ab initio electron density determination directly from solution scattering data
journal, January 2018


Molecular basis for activation of G protein-coupled receptor kinases
journal, August 2010

  • Boguth, Cassandra A.; Singh, Puja; Huang, Chih-chin
  • The EMBO Journal, Vol. 29, Issue 19
  • DOI: 10.1038/emboj.2010.206

Accurate SAXS Profile Computation and its Assessment by Contrast Variation Experiments
journal, August 2013

  • Schneidman-Duhovny, Dina; Hammel, Michal; Tainer, John A.
  • Biophysical Journal, Vol. 105, Issue 4
  • DOI: 10.1016/j.bpj.2013.07.020

CRYSOL – a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates
journal, December 1995

  • Svergun, D.; Barberato, C.; Koch, M. H. J.
  • Journal of Applied Crystallography, Vol. 28, Issue 6
  • DOI: 10.1107/S0021889895007047

Synucleins Are a Novel Class of Substrates for G Protein-coupled Receptor Kinases
journal, June 2000

  • Pronin, Alexey N.; Morris, Andrew J.; Surguchov, Andrei
  • Journal of Biological Chemistry, Vol. 275, Issue 34
  • DOI: 10.1074/jbc.M003542200

Myelin basic protein: a multifunctional protein
journal, June 2006


Function and Structure of MalA/MalA′, Iterative Halogenases for Late-Stage C–H Functionalization of Indole Alkaloids
journal, August 2017

  • Fraley, Amy E.; Garcia-Borràs, Marc; Tripathi, Ashootosh
  • Journal of the American Chemical Society, Vol. 139, Issue 34
  • DOI: 10.1021/jacs.7b06773

Inference of Macromolecular Assemblies from Crystalline State
journal, September 2007


Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors
journal, November 2015

  • Waldschmidt, Helen V.; Homan, Kristoff T.; Cruz-Rodríguez, Osvaldo
  • Journal of Medicinal Chemistry, Vol. 59, Issue 8
  • DOI: 10.1021/acs.jmedchem.5b02000

The many structural faces of calmodulin: a multitasking molecular jackknife
journal, July 2014


Target selectivity in EF-hand calcium binding proteins
journal, December 2004

  • Bhattacharya, Shibani; Bunick, Christopher G.; Chazin, Walter J.
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1742, Issue 1-3
  • DOI: 10.1016/j.bbamcr.2004.09.002

Recognition in the Face of Diversity: Interactions of Heterotrimeric G proteins and G Protein-coupled Receptor (GPCR) Kinases with Activated GPCRs
journal, January 2011

  • Huang, Chih-chin; Tesmer, John J. G.
  • Journal of Biological Chemistry, Vol. 286, Issue 10
  • DOI: 10.1074/jbc.R109.051847

Role of the Amino Terminus of G Protein-Coupled Receptor Kinase 2 in Receptor Phosphorylation
journal, August 2009

  • Pao, Christina S.; Barker, Breann L.; Benovic, Jeffrey L.
  • Biochemistry, Vol. 48, Issue 30
  • DOI: 10.1021/bi900408g

A Predicted Amphipathic Helix Mediates Plasma Membrane Localization of GRK5
journal, February 2004

  • Thiyagarajan, Manimekalai M.; Stracquatanio, RoseAnn P.; Pronin, Alexey N.
  • Journal of Biological Chemistry, Vol. 279, Issue 17
  • DOI: 10.1074/jbc.M310738200

Structure-Function Analysis of G Protein-coupled Receptor Kinase-5: ROLE OF THE CARBOXYL TERMINUS IN KINASE REGULATION
journal, November 1998

  • Pronin, Alexey N.; Carman, Christopher V.; Benovic, Jeffrey L.
  • Journal of Biological Chemistry, Vol. 273, Issue 47
  • DOI: 10.1074/jbc.273.47.31510

Regulation of the G Protein-coupled Receptor Kinase GRK5 by Protein Kinase C
journal, February 1997

  • Pronin, Alexey N.; Benovic, Jeffrey L.
  • Journal of Biological Chemistry, Vol. 272, Issue 6
  • DOI: 10.1074/jbc.272.6.3806

Regulation of G Protein-Coupled Receptor Kinases
journal, February 2000


G Protein-Coupled Receptor Kinase 5 Contains a DNA-Binding Nuclear Localization Sequence
journal, November 2004


Regulation of CaV2 calcium channels by G protein coupled receptors
journal, July 2013

  • Zamponi, Gerald W.; Currie, Kevin P. M.
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1828, Issue 7
  • DOI: 10.1016/j.bbamem.2012.10.004