The application of poorly crystalline silicotitanate in production of 225Ac

Fitzsimmons, Jonathan; Abraham, Alyson; Catalano, Demetra; Younes, Ali; Cutler, Cathy S.; Medvedev, Dmitri

doi:10.1038/s41598-019-48021-7

Title: The application of poorly crystalline silicotitanate in production of ²²⁵Ac

Journal Article · Wed Aug 14 00:00:00 EDT 2019 · Scientific Reports

DOI:https://doi.org/10.1038/s41598-019-48021-7· OSTI ID:1547020

Fitzsimmons, Jonathan ^[1]; Abraham, Alyson ^[2]; Catalano, Demetra ^[3]; Younes, Ali ^[1]; Cutler, Cathy S. ^[1]; Medvedev, Dmitri ^[1]

Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Division, Medical Isotope Research & Production Lab.
Stony Brook Univ., Stony Brook, NY (United States). Chemistry Dept.
Stony Brook Univ., Stony Brook, NY (United States). Biochemistry Dept.

Actinium-225 (²²⁵Ac) can be produced from a Thorium-229/Radium-225 (²²⁹Th/²²⁵Ra) generator, from high/low energy proton irradiated natural Thorium or Radium-226 target. Titanium based ion exchanger were evaluated for purification of ²²⁵Ac. Poorly crystalline silicotitanate (PCST) ion exchanger had high selectivity for Ba, Ag and Th. ²²⁵Ac was received with trace amounts of ²²⁷Ac, ²²⁷Th and ²²³Ra, and the solution was used to evaluate the retention of the isotopes on PCST ion exchanger. Over 90% of the ²²⁵Ac was recovered from PCST, and the radiopurity was >99% (calculated based on ²²⁵Ac, ²²⁷Th, and ²²³Ra). The capacity of the PCST inorganic ion exchange for Barium and ²³²Th was determined to be 24.19 mg/mL for Barium and 5.05 mg/mL for Thorium. PCST ion exchanger could separate ²²⁵Ac from isotopes of Ra and Th, and the process represents an interesting one step separation that could be used in an ²²⁵Ac generator from ²²⁵Ra and/or ²²⁹Th. Capacity studies indicated PCST could be used to separate ²²⁵Ac produced on small ²²⁶Ra targets (0.3–1 g), but PCST did not have a high enough capacity for production scale Th targets (50–100 g).

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP)

Grant/Contract Number:: SC0012704

OSTI ID:: 1547020

Report Number(s):: BNL-211944-2019-JAAM

Journal Information:: Scientific Reports, Vol. 9, Issue 1; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 5 works

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Guest Edited Collection: Radioisotopes and radiochemistry in health science Fassbender, Michael E. Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-019-56278-1	journal	January 2020

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Related Subjects

43 PARTICLE ACCELERATORS
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inorganic ion exchangers
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irradiation

Title: The application of poorly crystalline silicotitanate in production of 225Ac

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