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Title: HDX-MS reveals structural determinants for ROR[gamma] hyperactivation by synthetic agonists

Authors:
; ; ; ; ; ; ; ; ;  [1]
  1. Scripps
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
NCINIGMS
OSTI Identifier:
1545855
Resource Type:
Journal Article
Journal Name:
eLIFE J.
Additional Journal Information:
Journal Volume: 8; Journal Issue: 06, 2019
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Strutzenberg, Timothy S., Garcia-Ordonez, Ruben D., Novick, Scott J., Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Remi, Kamenecka, Theodore M., and Griffin, Patrick R. HDX-MS reveals structural determinants for ROR[gamma] hyperactivation by synthetic agonists. United States: N. p., 2020. Web. doi:10.7554/eLife.47172.
Strutzenberg, Timothy S., Garcia-Ordonez, Ruben D., Novick, Scott J., Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Remi, Kamenecka, Theodore M., & Griffin, Patrick R. HDX-MS reveals structural determinants for ROR[gamma] hyperactivation by synthetic agonists. United States. doi:10.7554/eLife.47172.
Strutzenberg, Timothy S., Garcia-Ordonez, Ruben D., Novick, Scott J., Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Remi, Kamenecka, Theodore M., and Griffin, Patrick R. Mon . "HDX-MS reveals structural determinants for ROR[gamma] hyperactivation by synthetic agonists". United States. doi:10.7554/eLife.47172.
@article{osti_1545855,
title = {HDX-MS reveals structural determinants for ROR[gamma] hyperactivation by synthetic agonists},
author = {Strutzenberg, Timothy S. and Garcia-Ordonez, Ruben D. and Novick, Scott J. and Park, HaJeung and Chang, Mi Ra and Doebellin, Christelle and He, Yuanjun and Patouret, Remi and Kamenecka, Theodore M. and Griffin, Patrick R.},
abstractNote = {},
doi = {10.7554/eLife.47172},
journal = {eLIFE J.},
number = 06, 2019,
volume = 8,
place = {United States},
year = {2020},
month = {8}
}

Works referenced in this record:

PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

Targeting the IL-17–TH17 pathway
journal, December 2014

  • Bartlett, Hilary S.; Million, Ryan P.
  • Nature Reviews Drug Discovery, Vol. 14, Issue 1
  • DOI: 10.1038/nrd4518

iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM
journal, March 2011

  • Battye, T. Geoff G.; Kontogiannis, Luke; Johnson, Owen
  • Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4
  • DOI: 10.1107/S0907444910048675

Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network
journal, August 2006


Probing Protein Ligand Interactions by Automated Hydrogen/Deuterium Exchange Mass Spectrometry
journal, February 2006

  • Chalmers, Michael J.; Busby, Scott A.; Pascal, Bruce D.
  • Analytical Chemistry, Vol. 78, Issue 4
  • DOI: 10.1021/ac051294f

Synthetic RORγt Agonists Enhance Protective Immunity
journal, January 2016

  • Chang, Mi Ra; Dharmarajan, Venkatasubramanian; Doebelin, Christelle
  • ACS Chemical Biology, Vol. 11, Issue 4
  • DOI: 10.1021/acschembio.5b00899

MolProbity : all-atom structure validation for macromolecular crystallography
journal, December 2009

  • Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1
  • DOI: 10.1107/S0907444909042073

N -Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists
journal, November 2016

  • Doebelin, Christelle; Patouret, Rémi; Garcia-Ordonez, Ruben D.
  • ChemMedChem, Vol. 11, Issue 23
  • DOI: 10.1002/cmdc.201600491

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists
journal, January 2015

  • Hu, Xiao; Wang, Yahong; Hao, Ling-Yang
  • Nature Chemical Biology, Vol. 11, Issue 2
  • DOI: 10.1038/nchembio.1714

Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity
journal, October 2016


The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
journal, September 2006


Structural Basis for Hydroxycholesterols as Natural Ligands of Orphan Nuclear Receptor RORγ
journal, May 2010

  • Jin, Lihua; Martynowski, Dariusz; Zheng, Songyang
  • Molecular Endocrinology, Vol. 24, Issue 5
  • DOI: 10.1210/me.2009-0507

Therapeutic potential of targeting IL-17
journal, October 2012

  • Jones, Sarah A.; Sutton, Caroline E.; Cua, Daniel
  • Nature Immunology, Vol. 13, Issue 11
  • DOI: 10.1038/ni.2450

XDS
journal, January 2010

  • Kabsch, Wolfgang
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2
  • DOI: 10.1107/S0907444909047337

Mapping Residual Structure in Intrinsically Disordered Proteins at Residue Resolution Using Millisecond Hydrogen/Deuterium Exchange and Residue Averaging
journal, December 2014

  • Keppel, Theodore R.; Weis, David D.
  • Journal of The American Society for Mass Spectrometry, Vol. 26, Issue 4
  • DOI: 10.1007/s13361-014-1033-6

Identification of SR2211: A Potent Synthetic RORγ-Selective Modulator
journal, February 2012

  • Kumar, Naresh; Lyda, Brent; Chang, Mi Ra
  • ACS Chemical Biology, Vol. 7, Issue 4
  • DOI: 10.1021/cb200496y

Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors
journal, May 2017

  • Li, Xiang; Anderson, Marie; Collin, Delphine
  • Journal of Biological Chemistry, Vol. 292, Issue 28
  • DOI: 10.1074/jbc.M117.789024

Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand
journal, June 2016


Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations
journal, July 2015


HDX Workbench: Software for the Analysis of H/D Exchange MS Data
journal, June 2012

  • Pascal, Bruce D.; Willis, Scooter; Lauer, Janelle L.
  • Journal of The American Society for Mass Spectrometry, Vol. 23, Issue 9
  • DOI: 10.1007/s13361-012-0419-6

UCSF Chimera?A visualization system for exploratory research and analysis
journal, January 2004

  • Pettersen, Eric F.; Goddard, Thomas D.; Huang, Conrad C.
  • Journal of Computational Chemistry, Vol. 25, Issue 13
  • DOI: 10.1002/jcc.20084

Nuclear receptor full-length architectures: confronting myth and illusion with high resolution
journal, January 2015

  • Rastinejad, Fraydoon; Ollendorff, Vincent; Polikarpov, Igor
  • Trends in Biochemical Sciences, Vol. 40, Issue 1
  • DOI: 10.1016/j.tibs.2014.10.011

Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells
journal, February 2015

  • Santori, Fabio R.; Huang, Pengxiang; van de Pavert, Serge A.
  • Cell Metabolism, Vol. 21, Issue 2
  • DOI: 10.1016/j.cmet.2015.01.004

Molecular Mechanism of Action of RORγt Agonists and Inverse Agonists: Insights from Molecular Dynamics Simulation
journal, December 2018


Current state of anti-PD-L1 and anti-PD-1 agents in cancer therapy
journal, October 2015


RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo
journal, June 2012

  • Takeda, Yukimasa; Jothi, Raja; Birault, Veronique
  • Nucleic Acids Research, Vol. 40, Issue 17
  • DOI: 10.1093/nar/gks630

ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer
journal, March 2016

  • Wang, Junjian; Zou, June X.; Xue, Xiaoqian
  • Nature Medicine, Vol. 22, Issue 5
  • DOI: 10.1038/nm.4070

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation
journal, April 1993