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Title: Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist

Authors:
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; more »; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;  [1] « less
  1. Karo Bio
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
INDUSTRY
OSTI Identifier:
1545840
Resource Type:
Journal Article
Journal Name:
J. Med. Chem.
Additional Journal Information:
Journal Volume: 61; Journal Issue: (23) ; 12, 2018
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Schnute, Mark E., Wennerstål, Mattias, Alley, Jennifer, Bengtsson, Martin, Blinn, James R., Bolten, Charles W., Braden, Timothy, Bonn, Tomas, Carlsson, Bo, Caspers, Nicole, Chen, Ming, Choi, Chulho, Collis, Leon P., Crouse, Kimberly, Färnegårdh, Mathias, Fennell, Kimberly F., Fish, Susan, Flick, Andrew C., Goos-Nilsson, Annika, Gullberg, Hjalmar, Harris, Peter K., Heasley, Steven E., Hegen, Martin, Hromockyj, Alexander E., Hu, Xiao, Husman, Bolette, Janosik, Tomasz, Jones, Peter, Kaila, Neelu, Kallin, Elisabet, Kauppi, Björn, Kiefer, James R., Knafels, John, Koehler, Konrad, Kruger, Lars, Kurumbail, Ravi G., Kyne, Jr., Robert E., Li, Wei, Löfstedt, Joakim, Long, Scott A., Menard, Carol A., Mente, Scot, Messing, Dean, Meyers, Marvin J., Napierata, Lee, Nöteberg, Daniel, Nuhant, Philippe, Pelc, Matthew J., Prinsen, Michael J., Rhönnstad, Patrik, Backström-Rydin, Eva, Sandberg, Johnny, Sandström, Maria, Shah, Falgun, Sjöberg, Maria, Sundell, Aron, Taylor, Alexandria P., Thorarensen, Atli, Trujillo, John I., Trzupek, John D., Unwalla, Ray, Vajdos, Felix F., Weinberg, Robin A., Wood, David C., Xing, Li, Zamaratski, Edouard, Zapf, Christoph W., Zhao, Yajuan, Wilhelmsson, Anna, Berstein, Gabriel, and Pfizer). Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist. United States: N. p., 2019. Web. doi:10.1021/acs.jmedchem.8b00392.
Schnute, Mark E., Wennerstål, Mattias, Alley, Jennifer, Bengtsson, Martin, Blinn, James R., Bolten, Charles W., Braden, Timothy, Bonn, Tomas, Carlsson, Bo, Caspers, Nicole, Chen, Ming, Choi, Chulho, Collis, Leon P., Crouse, Kimberly, Färnegårdh, Mathias, Fennell, Kimberly F., Fish, Susan, Flick, Andrew C., Goos-Nilsson, Annika, Gullberg, Hjalmar, Harris, Peter K., Heasley, Steven E., Hegen, Martin, Hromockyj, Alexander E., Hu, Xiao, Husman, Bolette, Janosik, Tomasz, Jones, Peter, Kaila, Neelu, Kallin, Elisabet, Kauppi, Björn, Kiefer, James R., Knafels, John, Koehler, Konrad, Kruger, Lars, Kurumbail, Ravi G., Kyne, Jr., Robert E., Li, Wei, Löfstedt, Joakim, Long, Scott A., Menard, Carol A., Mente, Scot, Messing, Dean, Meyers, Marvin J., Napierata, Lee, Nöteberg, Daniel, Nuhant, Philippe, Pelc, Matthew J., Prinsen, Michael J., Rhönnstad, Patrik, Backström-Rydin, Eva, Sandberg, Johnny, Sandström, Maria, Shah, Falgun, Sjöberg, Maria, Sundell, Aron, Taylor, Alexandria P., Thorarensen, Atli, Trujillo, John I., Trzupek, John D., Unwalla, Ray, Vajdos, Felix F., Weinberg, Robin A., Wood, David C., Xing, Li, Zamaratski, Edouard, Zapf, Christoph W., Zhao, Yajuan, Wilhelmsson, Anna, Berstein, Gabriel, & Pfizer). Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist. United States. doi:10.1021/acs.jmedchem.8b00392.
Schnute, Mark E., Wennerstål, Mattias, Alley, Jennifer, Bengtsson, Martin, Blinn, James R., Bolten, Charles W., Braden, Timothy, Bonn, Tomas, Carlsson, Bo, Caspers, Nicole, Chen, Ming, Choi, Chulho, Collis, Leon P., Crouse, Kimberly, Färnegårdh, Mathias, Fennell, Kimberly F., Fish, Susan, Flick, Andrew C., Goos-Nilsson, Annika, Gullberg, Hjalmar, Harris, Peter K., Heasley, Steven E., Hegen, Martin, Hromockyj, Alexander E., Hu, Xiao, Husman, Bolette, Janosik, Tomasz, Jones, Peter, Kaila, Neelu, Kallin, Elisabet, Kauppi, Björn, Kiefer, James R., Knafels, John, Koehler, Konrad, Kruger, Lars, Kurumbail, Ravi G., Kyne, Jr., Robert E., Li, Wei, Löfstedt, Joakim, Long, Scott A., Menard, Carol A., Mente, Scot, Messing, Dean, Meyers, Marvin J., Napierata, Lee, Nöteberg, Daniel, Nuhant, Philippe, Pelc, Matthew J., Prinsen, Michael J., Rhönnstad, Patrik, Backström-Rydin, Eva, Sandberg, Johnny, Sandström, Maria, Shah, Falgun, Sjöberg, Maria, Sundell, Aron, Taylor, Alexandria P., Thorarensen, Atli, Trujillo, John I., Trzupek, John D., Unwalla, Ray, Vajdos, Felix F., Weinberg, Robin A., Wood, David C., Xing, Li, Zamaratski, Edouard, Zapf, Christoph W., Zhao, Yajuan, Wilhelmsson, Anna, Berstein, Gabriel, and Pfizer). Fri . "Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist". United States. doi:10.1021/acs.jmedchem.8b00392.
@article{osti_1545840,
title = {Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist},
author = {Schnute, Mark E. and Wennerstål, Mattias and Alley, Jennifer and Bengtsson, Martin and Blinn, James R. and Bolten, Charles W. and Braden, Timothy and Bonn, Tomas and Carlsson, Bo and Caspers, Nicole and Chen, Ming and Choi, Chulho and Collis, Leon P. and Crouse, Kimberly and Färnegårdh, Mathias and Fennell, Kimberly F. and Fish, Susan and Flick, Andrew C. and Goos-Nilsson, Annika and Gullberg, Hjalmar and Harris, Peter K. and Heasley, Steven E. and Hegen, Martin and Hromockyj, Alexander E. and Hu, Xiao and Husman, Bolette and Janosik, Tomasz and Jones, Peter and Kaila, Neelu and Kallin, Elisabet and Kauppi, Björn and Kiefer, James R. and Knafels, John and Koehler, Konrad and Kruger, Lars and Kurumbail, Ravi G. and Kyne, Jr., Robert E. and Li, Wei and Löfstedt, Joakim and Long, Scott A. and Menard, Carol A. and Mente, Scot and Messing, Dean and Meyers, Marvin J. and Napierata, Lee and Nöteberg, Daniel and Nuhant, Philippe and Pelc, Matthew J. and Prinsen, Michael J. and Rhönnstad, Patrik and Backström-Rydin, Eva and Sandberg, Johnny and Sandström, Maria and Shah, Falgun and Sjöberg, Maria and Sundell, Aron and Taylor, Alexandria P. and Thorarensen, Atli and Trujillo, John I. and Trzupek, John D. and Unwalla, Ray and Vajdos, Felix F. and Weinberg, Robin A. and Wood, David C. and Xing, Li and Zamaratski, Edouard and Zapf, Christoph W. and Zhao, Yajuan and Wilhelmsson, Anna and Berstein, Gabriel and Pfizer)},
abstractNote = {},
doi = {10.1021/acs.jmedchem.8b00392},
journal = {J. Med. Chem.},
number = (23) ; 12, 2018,
volume = 61,
place = {United States},
year = {2019},
month = {7}
}