skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Electrochemical Sensors and Biosensors Based on Nanomaterials and Nanostructures

Abstract

Taking advantages of exceptional attributes, such as easy-to-operate, economical, sensitive, portable, and simple-to- construct, considerable attention has been devoted to the integration of recognition elements with electronic elements to develop electrochemical sensors and biosensors. Recent decades tremendous amounts of attention have been witnessed in this active area. Various electrochemical devices such as amperometric sensors, electrochemical impedance sensors, electrochemical luminescence sensors as well as photoelectrochemical sensors, provide wide applications of detecting chemical and biological targets in terms of electrochemical change of electrode interfaces. With remarkable achievements in nanotechnology and nanoscience, nanomaterial-based electrochemical signal amplifications have great potential of improving both in sensitivity and selectivity for electrochemical sensors and biosensors. First of all, it is well known that the electrode materials play a critical role in the construction of high-performance electrochemical sensing platforms for detecting target molecules through various analytical principles. Furthermore, in addition to electrode materials, functional nanomaterials can not only produce a synergic effect among catalytic activity, conductivity and biocompatibility to accelerate the signal transduction, but also amplify biorecognition events by specifically designed signal tags, leading to highly sensitive biosensing. Sig-nificantly, extensive research on construction of functional electrode materials, coupled with numerous electrochemical methods, is advancing wide applications of electrochemicalmore » devices. For example, Walcarius et al. highlighted the recent advances of nano-objects, nano-engineered and/or nanostructured materials for the rational design of bio-functionalized electrodes and related (bio)sensing systems.1 The attractiveness of such nanomaterials relies on their ability to act as effective immobilization matrices, and their intrinsic and unique features as described above. These features combined with the functioning of biomolecules contribute to the improvement of bioelectrode performance in terms of sensitivity and specificity. Our group recently presented a general overview of nanomaterial-enhanced paper-based biosensors including lateral-flow test-strip, and paper microfluidic devices.2With different kinds of nanoparticles (NPs), paper-based biosensor devices have shown great potential in the enhancement of sensitivity and specificity of disease diagnosis in developing countries. This review focuses on recent advances in electrochemical sensors and biosensors based on nanomaterials and nanostructures during 2013 to 2014. The aim of this effort is to provide the reader with a clear and concise view of new advances in areas ranging from electrode engineering, strategies for electrochemical signal amplification, and novel electroanalytical techniques used to the miniaturization and integration of the sensors. Moreover, the authors have attempted to highlight areas of latest and significant development of enhanced elec-trochemical nanosensors and nanobiosensors that inspire broader interests across various disciplines. Electrochemical sensors for small molecules, enzyme-based biosensors, genosensors, immunosensors and cytosensors are reviewed herein (Figure 1). Such novel advances are important for the development of electrochemical sensors as that open up new avenues and methods for future research. Readers interested in the general principles of electrochemical sensors and electrochemical methods are recommended to refer to other excellent literature for a broad scope on this area.3-4 However, due to the explosion of publications in this active field, we do not claim that this review includes all of the published works in the past two years. Due to the large activity in this field we apologize to the authors of excellent work, which is unintentionally left out.« less

Authors:
 [1];  [1];  [1];  [2]; ORCiD logo [2]
  1. Washington State University
  2. WASHINGTON STATE UNIV
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1545036
Report Number(s):
PNNL-SA-107495
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Analytical Chemistry
Additional Journal Information:
Journal Volume: 87; Journal Issue: 1
Country of Publication:
United States
Language:
English

Citation Formats

Zhu, Chengzhou, Yang, Guohai, Li, He, Du, Dan, and Lin, Yuehe. Electrochemical Sensors and Biosensors Based on Nanomaterials and Nanostructures. United States: N. p., 2015. Web. doi:10.1021/ac5039863.
Zhu, Chengzhou, Yang, Guohai, Li, He, Du, Dan, & Lin, Yuehe. Electrochemical Sensors and Biosensors Based on Nanomaterials and Nanostructures. United States. doi:10.1021/ac5039863.
Zhu, Chengzhou, Yang, Guohai, Li, He, Du, Dan, and Lin, Yuehe. Tue . "Electrochemical Sensors and Biosensors Based on Nanomaterials and Nanostructures". United States. doi:10.1021/ac5039863.
@article{osti_1545036,
title = {Electrochemical Sensors and Biosensors Based on Nanomaterials and Nanostructures},
author = {Zhu, Chengzhou and Yang, Guohai and Li, He and Du, Dan and Lin, Yuehe},
abstractNote = {Taking advantages of exceptional attributes, such as easy-to-operate, economical, sensitive, portable, and simple-to- construct, considerable attention has been devoted to the integration of recognition elements with electronic elements to develop electrochemical sensors and biosensors. Recent decades tremendous amounts of attention have been witnessed in this active area. Various electrochemical devices such as amperometric sensors, electrochemical impedance sensors, electrochemical luminescence sensors as well as photoelectrochemical sensors, provide wide applications of detecting chemical and biological targets in terms of electrochemical change of electrode interfaces. With remarkable achievements in nanotechnology and nanoscience, nanomaterial-based electrochemical signal amplifications have great potential of improving both in sensitivity and selectivity for electrochemical sensors and biosensors. First of all, it is well known that the electrode materials play a critical role in the construction of high-performance electrochemical sensing platforms for detecting target molecules through various analytical principles. Furthermore, in addition to electrode materials, functional nanomaterials can not only produce a synergic effect among catalytic activity, conductivity and biocompatibility to accelerate the signal transduction, but also amplify biorecognition events by specifically designed signal tags, leading to highly sensitive biosensing. Sig-nificantly, extensive research on construction of functional electrode materials, coupled with numerous electrochemical methods, is advancing wide applications of electrochemical devices. For example, Walcarius et al. highlighted the recent advances of nano-objects, nano-engineered and/or nanostructured materials for the rational design of bio-functionalized electrodes and related (bio)sensing systems.1 The attractiveness of such nanomaterials relies on their ability to act as effective immobilization matrices, and their intrinsic and unique features as described above. These features combined with the functioning of biomolecules contribute to the improvement of bioelectrode performance in terms of sensitivity and specificity. Our group recently presented a general overview of nanomaterial-enhanced paper-based biosensors including lateral-flow test-strip, and paper microfluidic devices.2With different kinds of nanoparticles (NPs), paper-based biosensor devices have shown great potential in the enhancement of sensitivity and specificity of disease diagnosis in developing countries. This review focuses on recent advances in electrochemical sensors and biosensors based on nanomaterials and nanostructures during 2013 to 2014. The aim of this effort is to provide the reader with a clear and concise view of new advances in areas ranging from electrode engineering, strategies for electrochemical signal amplification, and novel electroanalytical techniques used to the miniaturization and integration of the sensors. Moreover, the authors have attempted to highlight areas of latest and significant development of enhanced elec-trochemical nanosensors and nanobiosensors that inspire broader interests across various disciplines. Electrochemical sensors for small molecules, enzyme-based biosensors, genosensors, immunosensors and cytosensors are reviewed herein (Figure 1). Such novel advances are important for the development of electrochemical sensors as that open up new avenues and methods for future research. Readers interested in the general principles of electrochemical sensors and electrochemical methods are recommended to refer to other excellent literature for a broad scope on this area.3-4 However, due to the explosion of publications in this active field, we do not claim that this review includes all of the published works in the past two years. Due to the large activity in this field we apologize to the authors of excellent work, which is unintentionally left out.},
doi = {10.1021/ac5039863},
journal = {Analytical Chemistry},
number = 1,
volume = 87,
place = {United States},
year = {2015},
month = {1}
}

Works referencing / citing this record:

Electrochemical sensing of cocaine in real samples based on electrodeposited biomimetic affinity ligands
journal, January 2019

  • Florea, Anca; Cowen, Todd; Piletsky, Sergey
  • The Analyst, Vol. 144, Issue 15
  • DOI: 10.1039/c9an00618d

The influence of the shape of Au nanoparticles on the catalytic current of fructose dehydrogenase
journal, July 2019

  • Bollella, Paolo; Hibino, Yuya; Conejo-Valverde, Paolo
  • Analytical and Bioanalytical Chemistry, Vol. 411, Issue 29
  • DOI: 10.1007/s00216-019-01944-6

A review on graphene-based nanocomposites for electrochemical and fluorescent biosensors
journal, January 2019

  • Krishnan, Siva Kumar; Singh, Eric; Singh, Pragya
  • RSC Advances, Vol. 9, Issue 16
  • DOI: 10.1039/c8ra09577a

The Use of Electrochemical Biosensors in Food Analysis
journal, October 2017

  • Bunney, John; Williamson, Shae; Atkin, Dianne
  • Current Research in Nutrition and Food Science Journal, Vol. 5, Issue 3
  • DOI: 10.12944/crnfsj.5.3.02

Fast Procedures for the Electrodeposition of Platinum Nanostructures on Miniaturized Electrodes for Improved Ion Sensing
journal, May 2019

  • Criscuolo, Francesca; Taurino, Irene; Dam, Van
  • Sensors, Vol. 19, Issue 10
  • DOI: 10.3390/s19102260

The influence of the shape of Au nanoparticles on the catalytic current of fructose dehydrogenase
journal, July 2019

  • Bollella, Paolo; Hibino, Yuya; Conejo-Valverde, Paolo
  • Analytical and Bioanalytical Chemistry, Vol. 411, Issue 29
  • DOI: 10.1007/s00216-019-01944-6

Novel fabrication of a laccase biosensor to detect phenolic compounds using a carboxylated multiwalled carbon nanotube on the electropolymerized support
journal, June 2019

  • Albayati, Shahad Abdul Rasol; Kashanian, Soheila; Nazari, Maryam
  • Bulletin of Materials Science, Vol. 42, Issue 4
  • DOI: 10.1007/s12034-019-1850-0

Nanomaterials in label-free impedimetric biosensor: Current process and future perspectives
journal, November 2016


A review on graphene-based nanocomposites for electrochemical and fluorescent biosensors
journal, January 2019

  • Krishnan, Siva Kumar; Singh, Eric; Singh, Pragya
  • RSC Advances, Vol. 9, Issue 16
  • DOI: 10.1039/c8ra09577a

Electrochemical sensing of cocaine in real samples based on electrodeposited biomimetic affinity ligands
journal, January 2019

  • Florea, Anca; Cowen, Todd; Piletsky, Sergey
  • The Analyst, Vol. 144, Issue 15
  • DOI: 10.1039/c9an00618d

The Use of Electrochemical Biosensors in Food Analysis
journal, October 2017

  • Bunney, John; Williamson, Shae; Atkin, Dianne
  • Current Research in Nutrition and Food Science Journal, Vol. 5, Issue 3
  • DOI: 10.12944/crnfsj.5.3.02

Development of MoSe2 Nano-Urchins as a Sensing Platform for a Selective Bio-Capturing of Escherichia. coli Shiga Toxin DNA
journal, August 2018

  • Narang, Jagriti; Mishra, Annu; Pilloton, Roberto
  • Biosensors, Vol. 8, Issue 3
  • DOI: 10.3390/bios8030077

Fast Procedures for the Electrodeposition of Platinum Nanostructures on Miniaturized Electrodes for Improved Ion Sensing
journal, May 2019

  • Criscuolo, Francesca; Taurino, Irene; Dam, Van
  • Sensors, Vol. 19, Issue 10
  • DOI: 10.3390/s19102260

Enzyme-Based Electrochemical Biosensors for Microfluidic Platforms to Detect Pharmaceutical Residues in Wastewater
journal, March 2019

  • Campaña, Ana; Florez, Sergio; Noguera, Mabel
  • Biosensors, Vol. 9, Issue 1
  • DOI: 10.3390/bios9010041