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Title: Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase


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Harris, Philip A., Faucher, Nicolas, George, Nicolas, Eidam, Patrick M., King, Bryan W., White, Gemma V., Anderson, Niall A., Bandyopadhyay, Deepak, Beal, Allison M., Beneton, Veronique, Berger, Scott B., Campobasso, Nino, Campos, Sebastien, Capriotti, Carol A., Cox, Julie A., Daugan, Alain, Donche, Frederic, Fouchet, Marie-Hélène, Finger, Joshua N., Geddes, Brad, Gough, Peter J., Grondin, Pascal, Hoffman, Bonnie L., Hoffman, Sandra J., Hutchinson, Susan E., Jeong, Jae U., Jigorel, Emilie, Lamoureux, Pauline, Leister, Lara K., Lich, John D., Mahajan, Mukesh K., Meslamani, Jamel, Mosley, Julie E., Nagilla, Rakesh, Nassau, Pamela M., Ng, Sze-Ling, Ouellette, Michael T., Pasikanti, Kishore K., Potvain, Florent, Reilly, Michael A., Rivera, Elizabeth J., Sautet, Stéphane, Schaeffer, Michelle C., Sehon, Clark A., Sun, Helen, Thorpe, James H., Totoritis, Rachel D., Ward, Paris, Wellaway, Natalie, Wisnoski, David D., Woolven, James M., Bertin, John, Marquis, Robert W., and GSKPA). Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. United States: N. p., 2019. Web. doi:10.1021/acs.jmedchem.9b00318.
Harris, Philip A., Faucher, Nicolas, George, Nicolas, Eidam, Patrick M., King, Bryan W., White, Gemma V., Anderson, Niall A., Bandyopadhyay, Deepak, Beal, Allison M., Beneton, Veronique, Berger, Scott B., Campobasso, Nino, Campos, Sebastien, Capriotti, Carol A., Cox, Julie A., Daugan, Alain, Donche, Frederic, Fouchet, Marie-Hélène, Finger, Joshua N., Geddes, Brad, Gough, Peter J., Grondin, Pascal, Hoffman, Bonnie L., Hoffman, Sandra J., Hutchinson, Susan E., Jeong, Jae U., Jigorel, Emilie, Lamoureux, Pauline, Leister, Lara K., Lich, John D., Mahajan, Mukesh K., Meslamani, Jamel, Mosley, Julie E., Nagilla, Rakesh, Nassau, Pamela M., Ng, Sze-Ling, Ouellette, Michael T., Pasikanti, Kishore K., Potvain, Florent, Reilly, Michael A., Rivera, Elizabeth J., Sautet, Stéphane, Schaeffer, Michelle C., Sehon, Clark A., Sun, Helen, Thorpe, James H., Totoritis, Rachel D., Ward, Paris, Wellaway, Natalie, Wisnoski, David D., Woolven, James M., Bertin, John, Marquis, Robert W., & GSKPA). Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. United States. doi:10.1021/acs.jmedchem.9b00318.
Harris, Philip A., Faucher, Nicolas, George, Nicolas, Eidam, Patrick M., King, Bryan W., White, Gemma V., Anderson, Niall A., Bandyopadhyay, Deepak, Beal, Allison M., Beneton, Veronique, Berger, Scott B., Campobasso, Nino, Campos, Sebastien, Capriotti, Carol A., Cox, Julie A., Daugan, Alain, Donche, Frederic, Fouchet, Marie-Hélène, Finger, Joshua N., Geddes, Brad, Gough, Peter J., Grondin, Pascal, Hoffman, Bonnie L., Hoffman, Sandra J., Hutchinson, Susan E., Jeong, Jae U., Jigorel, Emilie, Lamoureux, Pauline, Leister, Lara K., Lich, John D., Mahajan, Mukesh K., Meslamani, Jamel, Mosley, Julie E., Nagilla, Rakesh, Nassau, Pamela M., Ng, Sze-Ling, Ouellette, Michael T., Pasikanti, Kishore K., Potvain, Florent, Reilly, Michael A., Rivera, Elizabeth J., Sautet, Stéphane, Schaeffer, Michelle C., Sehon, Clark A., Sun, Helen, Thorpe, James H., Totoritis, Rachel D., Ward, Paris, Wellaway, Natalie, Wisnoski, David D., Woolven, James M., Bertin, John, Marquis, Robert W., and GSKPA). Tue . "Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase". United States. doi:10.1021/acs.jmedchem.9b00318.
@article{osti_1544867,
title = {Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase},
author = {Harris, Philip A. and Faucher, Nicolas and George, Nicolas and Eidam, Patrick M. and King, Bryan W. and White, Gemma V. and Anderson, Niall A. and Bandyopadhyay, Deepak and Beal, Allison M. and Beneton, Veronique and Berger, Scott B. and Campobasso, Nino and Campos, Sebastien and Capriotti, Carol A. and Cox, Julie A. and Daugan, Alain and Donche, Frederic and Fouchet, Marie-Hélène and Finger, Joshua N. and Geddes, Brad and Gough, Peter J. and Grondin, Pascal and Hoffman, Bonnie L. and Hoffman, Sandra J. and Hutchinson, Susan E. and Jeong, Jae U. and Jigorel, Emilie and Lamoureux, Pauline and Leister, Lara K. and Lich, John D. and Mahajan, Mukesh K. and Meslamani, Jamel and Mosley, Julie E. and Nagilla, Rakesh and Nassau, Pamela M. and Ng, Sze-Ling and Ouellette, Michael T. and Pasikanti, Kishore K. and Potvain, Florent and Reilly, Michael A. and Rivera, Elizabeth J. and Sautet, Stéphane and Schaeffer, Michelle C. and Sehon, Clark A. and Sun, Helen and Thorpe, James H. and Totoritis, Rachel D. and Ward, Paris and Wellaway, Natalie and Wisnoski, David D. and Woolven, James M. and Bertin, John and Marquis, Robert W. and GSKPA)},
abstractNote = {},
doi = {10.1021/acs.jmedchem.9b00318},
journal = {J. Med. Chem.},
number = (10) ; 04, 2019,
volume = 62,
place = {United States},
year = {2019},
month = {7}
}