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Mimicking a p53;#8208;MDM2 interaction based on a stable immunoglobulin;#8208;like domain scaffold

Journal Article · · Proteins
DOI:https://doi.org/10.1002/prot.25519· OSTI ID:1544851

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
FOREIGN
OSTI ID:
1544851
Journal Information:
Proteins, Vol. 86, Issue (7) ; 07, 2018
Country of Publication:
United States
Language:
ENGLISH

References (48)

Dominant forces in protein folding journal August 1990
Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2 journal April 1996
Bacterial expression of immunoglobulin fragments journal January 1993
Isolation of engineered, full-length antibodies from libraries expressed in Escherichia coli journal April 2007
Comprehensive engineering of Escherichia coli for enhanced expression of IgG antibodies journal March 2011
High-affinity, Peptide-specific T Cell Receptors can be Generated by Mutations in CDR1, CDR2 or CDR3 journal February 2005
SH3 domains with high affinity and engineered ligand specificities targeted to HIV-1 Nef 1 1Edited by J. Karn journal November 1999
The fibronectin type III domain as a scaffold for novel binding proteins journal December 1998
High-affinity binders selected from designed ankyrin repeat protein libraries journal April 2004
Green fluorescent protein as a scaffold for intracellular presentation of peptides journal January 1998
Peptide Aptamers: Development and Applications journal April 2015
Alternative non-antibody scaffolds for molecular recognition journal August 2007
Proposed acquisition of an animal protein domain by bacteria. journal October 1992
Solution structure of a bacterial immunoglobulin-like domain of the outer membrane protein (LigB) from L eptospira : Structure of Big Domain journal November 2014
Exploring the potential of the monobody scaffold: effects of loop elongation on the stability of a fibronectin type III domain journal December 2002
Cysteine Proteases Inhibitors with Immunoglobulin-Like Fold in Protozoan Parasites and their Role in Pathogenesis journal August 2017
Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors journal November 2015
Natural cysteine protease inhibitors in protozoa: Fifteen years of the chagasin family journal March 2016
The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of an Inhibitor Family journal May 2007
Crystal structure of the cysteine protease inhibitor 2 from Entamoeba histolytica: Functional convergence of a common protein fold journal January 2011
A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein–Protein Interfaces journal August 2008
Evolution of an Interloop Disulfide Bond in High-Affinity Antibody Mimics Based on Fibronectin Type III Domain and Selected by Yeast Surface Display: Molecular Convergence with Single-Domain Camelid and Shark Antibodies journal May 2007
Molecular Recognition Properties of FN3 Monobodies that Bind the Src SH3 Domain journal June 2004
Design of protein function leaps by directed domain interface evolution journal April 2008
Picomolar Affinity Fibronectin Domains Engineered Utilizing Loop Length Diversity, Recursive Mutagenesis, and Loop Shuffling journal September 2008
Crystal structure of chagasin, the endogenous cysteine-protease inhibitor from Trypanosoma cruzi journal February 2007
Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases: Chagasin-papain complex structure journal January 2009
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution journal March 1992
Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen journal February 1998
Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX journal March 2009
Mapping the Folding Pathway of an Immunoglobulin Domain journal May 2001
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM journal March 2011
Phaser crystallographic software journal July 2007
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Towards automated crystallographic structure refinement with phenix.refine journal March 2012
REFMAC 5 dictionary: organization of prior chemical knowledge and guidelines for its use journal November 2004
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009
Rational Design and Biophysical Characterization of Thioredoxin-Based Aptamers: Insights into Peptide Grafting journal January 2010
Antibody mimics based on human fibronectin type three domain engineered for thermostability and high-affinity binding to vascular endothelial growth factor receptor two journal August 2005
The central region of HDM2 provides a second binding site for p53 journal January 2006
The I-TASSER Suite: protein structure and function prediction journal December 2014
Extraction of Thermodynamic Parameters of Protein Unfolding Using Parallelized Differential Scanning Fluorimetry journal January 2017
Structure of Human MDM4 N-Terminal Domain Bound to a Single-Domain Antibody journal February 2009
A Novel Unstructured Scaffold Based on 4EBP1 Enables the Functional Display of a Wide Range of Bioactive Peptides journal December 2010
The importance of loop length in the folding of an immunoglobulin domain journal June 2004
Cross-Talk between Malarial Cysteine Proteases and Falstatin: The BC Loop as a Hot-Spot Target journal April 2014
Systemic Amyloidoses journal June 2013
A script to highlight hydrophobicity and charge on protein surfaces journal October 2015

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