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Title: Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Authors:
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  1. Pfizer
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
INDUSTRY
OSTI Identifier:
1544834
Resource Type:
Journal Article
Journal Name:
J. Med. Chem.
Additional Journal Information:
Journal Volume: 61; Journal Issue: (19) ; 10, 2018
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Fensome, Andrew, Ambler, Catherine M., Arnold, Eric, Banker, Mary Ellen, Brown, Matthew F., Chrencik, Jill, Clark, James D., Dowty, Martin E., Efremov, Ivan V., Flick, Andrew, Gerstenberger, Brian S., Gopalsamy, Ariamala, Hayward, Matthew M., Hegen, Martin, Hollingshead, Brett D., Jussif, Jason, Knafels, John D., Limburg, David C., Lin, David, Lin, Tsung H., Pierce, Betsy S., Saiah, Eddine, Sharma, Raman, Symanowicz, Peter T., Telliez, Jean-Baptiste, Trujillo, John I., Vajdos, Felix F., Vincent, Fabien, Wan, Zhao-Kui, Xing, Li, Yang, Xiaojing, Yang, Xin, and Zhang, Liying. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). United States: N. p., 2019. Web. doi:10.1021/acs.jmedchem.8b00917.
Fensome, Andrew, Ambler, Catherine M., Arnold, Eric, Banker, Mary Ellen, Brown, Matthew F., Chrencik, Jill, Clark, James D., Dowty, Martin E., Efremov, Ivan V., Flick, Andrew, Gerstenberger, Brian S., Gopalsamy, Ariamala, Hayward, Matthew M., Hegen, Martin, Hollingshead, Brett D., Jussif, Jason, Knafels, John D., Limburg, David C., Lin, David, Lin, Tsung H., Pierce, Betsy S., Saiah, Eddine, Sharma, Raman, Symanowicz, Peter T., Telliez, Jean-Baptiste, Trujillo, John I., Vajdos, Felix F., Vincent, Fabien, Wan, Zhao-Kui, Xing, Li, Yang, Xiaojing, Yang, Xin, & Zhang, Liying. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). United States. doi:10.1021/acs.jmedchem.8b00917.
Fensome, Andrew, Ambler, Catherine M., Arnold, Eric, Banker, Mary Ellen, Brown, Matthew F., Chrencik, Jill, Clark, James D., Dowty, Martin E., Efremov, Ivan V., Flick, Andrew, Gerstenberger, Brian S., Gopalsamy, Ariamala, Hayward, Matthew M., Hegen, Martin, Hollingshead, Brett D., Jussif, Jason, Knafels, John D., Limburg, David C., Lin, David, Lin, Tsung H., Pierce, Betsy S., Saiah, Eddine, Sharma, Raman, Symanowicz, Peter T., Telliez, Jean-Baptiste, Trujillo, John I., Vajdos, Felix F., Vincent, Fabien, Wan, Zhao-Kui, Xing, Li, Yang, Xiaojing, Yang, Xin, and Zhang, Liying. Fri . "Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)". United States. doi:10.1021/acs.jmedchem.8b00917.
@article{osti_1544834,
title = {Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)},
author = {Fensome, Andrew and Ambler, Catherine M. and Arnold, Eric and Banker, Mary Ellen and Brown, Matthew F. and Chrencik, Jill and Clark, James D. and Dowty, Martin E. and Efremov, Ivan V. and Flick, Andrew and Gerstenberger, Brian S. and Gopalsamy, Ariamala and Hayward, Matthew M. and Hegen, Martin and Hollingshead, Brett D. and Jussif, Jason and Knafels, John D. and Limburg, David C. and Lin, David and Lin, Tsung H. and Pierce, Betsy S. and Saiah, Eddine and Sharma, Raman and Symanowicz, Peter T. and Telliez, Jean-Baptiste and Trujillo, John I. and Vajdos, Felix F. and Vincent, Fabien and Wan, Zhao-Kui and Xing, Li and Yang, Xiaojing and Yang, Xin and Zhang, Liying},
abstractNote = {},
doi = {10.1021/acs.jmedchem.8b00917},
journal = {J. Med. Chem.},
number = (19) ; 10, 2018,
volume = 61,
place = {United States},
year = {2019},
month = {7}
}