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Title: Ion mobility spectrometry and the omics: Distinguishing isomers, molecular classes and contaminant ions in complex samples

Abstract

Ion mobility spectrometry (IMS) is a widely used analytical technique providing rapid gas phase separations. IMS alone is useful, but its coupling with mass spectrometry (IMS-MS) and various front-end separation techniques has greatly increased the molecular information achievable from omic analyses, including the sensitivity and peak capacity extracted from complex biological and environmental sample analyses. Due to these characteristics, IMS-MS is rapidly gaining attention for improving metabolomic, lipidomic, glycomic, proteomic and exposomic analyses. Numerous studies including national security-related analyses, disease screenings and environmental evaluations are illustrating that IMS-MS is able to extract information not possible with MS alone. Furthermore, IMS-MS has shown great utility in salvaging molecular information for low abundance molecules of interest when high concentration contaminant ions are present in the sample. This review highlights how IMS-MS is currently being used in omic analyses to distinguish structurally similar molecules, isomers, molecular classes and contaminant ions.

Authors:
ORCiD logo [1];  [2];  [3];  [3];  [3]; ORCiD logo [1];  [1]; ORCiD logo [1]; ORCiD logo [1];  [1]; ORCiD logo [1]; ORCiD logo [1]
  1. BATTELLE (PACIFIC NW LAB)
  2. Texas A & M University
  3. North Carolina State University
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1544783
Report Number(s):
PNNL-SA-140985
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Trends in Analytical Chemistry. TrAC
Additional Journal Information:
Journal Volume: 116
Country of Publication:
United States
Language:
English
Subject:
Ion mobility spectrometry,, Mass Spectometry, Omics, Proteomics, Lipidomics, Mtabolomics, glycomics, exposomics

Citation Formats

Burnum-Johnson, Kristin E., Zheng, Xueyun, Dodds, James N., Ash, Jeremy, Fourches, Denis, Nicora, Carrie D., Wendler, Jason P., Metz, Thomas O., Waters, Katrina M., Jansson, Janet K., Smith, Richard D., and Baker, Erin M. Ion mobility spectrometry and the omics: Distinguishing isomers, molecular classes and contaminant ions in complex samples. United States: N. p., 2019. Web. doi:10.1016/j.trac.2019.04.022.
Burnum-Johnson, Kristin E., Zheng, Xueyun, Dodds, James N., Ash, Jeremy, Fourches, Denis, Nicora, Carrie D., Wendler, Jason P., Metz, Thomas O., Waters, Katrina M., Jansson, Janet K., Smith, Richard D., & Baker, Erin M. Ion mobility spectrometry and the omics: Distinguishing isomers, molecular classes and contaminant ions in complex samples. United States. doi:10.1016/j.trac.2019.04.022.
Burnum-Johnson, Kristin E., Zheng, Xueyun, Dodds, James N., Ash, Jeremy, Fourches, Denis, Nicora, Carrie D., Wendler, Jason P., Metz, Thomas O., Waters, Katrina M., Jansson, Janet K., Smith, Richard D., and Baker, Erin M. Mon . "Ion mobility spectrometry and the omics: Distinguishing isomers, molecular classes and contaminant ions in complex samples". United States. doi:10.1016/j.trac.2019.04.022.
@article{osti_1544783,
title = {Ion mobility spectrometry and the omics: Distinguishing isomers, molecular classes and contaminant ions in complex samples},
author = {Burnum-Johnson, Kristin E. and Zheng, Xueyun and Dodds, James N. and Ash, Jeremy and Fourches, Denis and Nicora, Carrie D. and Wendler, Jason P. and Metz, Thomas O. and Waters, Katrina M. and Jansson, Janet K. and Smith, Richard D. and Baker, Erin M.},
abstractNote = {Ion mobility spectrometry (IMS) is a widely used analytical technique providing rapid gas phase separations. IMS alone is useful, but its coupling with mass spectrometry (IMS-MS) and various front-end separation techniques has greatly increased the molecular information achievable from omic analyses, including the sensitivity and peak capacity extracted from complex biological and environmental sample analyses. Due to these characteristics, IMS-MS is rapidly gaining attention for improving metabolomic, lipidomic, glycomic, proteomic and exposomic analyses. Numerous studies including national security-related analyses, disease screenings and environmental evaluations are illustrating that IMS-MS is able to extract information not possible with MS alone. Furthermore, IMS-MS has shown great utility in salvaging molecular information for low abundance molecules of interest when high concentration contaminant ions are present in the sample. This review highlights how IMS-MS is currently being used in omic analyses to distinguish structurally similar molecules, isomers, molecular classes and contaminant ions.},
doi = {10.1016/j.trac.2019.04.022},
journal = {Trends in Analytical Chemistry. TrAC},
number = ,
volume = 116,
place = {United States},
year = {2019},
month = {7}
}