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Title: Opening new paths for biological applications of ion mobility - Mass spectrometry using structures for lossless ion manipulations

Abstract

Ion mobility separations coupled to mass spectrometry (IM-MS) have received much attention for their ability to provide complementary structural information to solution-phase-based separations, as well as to aid in the identification of unknown compounds. While IM-MS is an increasingly powerful analytical technique, significant bottlenecks related to the resolution and sensitivity of measurements have kept it from becoming broadly applied for biological analyses. Structures for Lossless Ion Manipulations (SLIM)-based IM separations have successfully overcome these aforementioned bottlenecks, addressing issues associated with resolution and sensitivity in the omics, and potentially opening the door to broader application.

Authors:
ORCiD logo [1];  [1]; ORCiD logo [1]; ORCiD logo [1]
  1. BATTELLE (PACIFIC NW LAB)
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1544781
Report Number(s):
PNNL-SA-140349
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Trends in Analytical Chemistry. TrAC
Additional Journal Information:
Journal Volume: 116
Country of Publication:
United States
Language:
English

Citation Formats

Garimella, Venkata BS, Nagy, Gavril, Ibrahim, Yehia M., and Smith, Richard D. Opening new paths for biological applications of ion mobility - Mass spectrometry using structures for lossless ion manipulations. United States: N. p., 2019. Web. doi:10.1016/j.trac.2019.04.021.
Garimella, Venkata BS, Nagy, Gavril, Ibrahim, Yehia M., & Smith, Richard D. Opening new paths for biological applications of ion mobility - Mass spectrometry using structures for lossless ion manipulations. United States. doi:10.1016/j.trac.2019.04.021.
Garimella, Venkata BS, Nagy, Gavril, Ibrahim, Yehia M., and Smith, Richard D. Mon . "Opening new paths for biological applications of ion mobility - Mass spectrometry using structures for lossless ion manipulations". United States. doi:10.1016/j.trac.2019.04.021.
@article{osti_1544781,
title = {Opening new paths for biological applications of ion mobility - Mass spectrometry using structures for lossless ion manipulations},
author = {Garimella, Venkata BS and Nagy, Gavril and Ibrahim, Yehia M. and Smith, Richard D.},
abstractNote = {Ion mobility separations coupled to mass spectrometry (IM-MS) have received much attention for their ability to provide complementary structural information to solution-phase-based separations, as well as to aid in the identification of unknown compounds. While IM-MS is an increasingly powerful analytical technique, significant bottlenecks related to the resolution and sensitivity of measurements have kept it from becoming broadly applied for biological analyses. Structures for Lossless Ion Manipulations (SLIM)-based IM separations have successfully overcome these aforementioned bottlenecks, addressing issues associated with resolution and sensitivity in the omics, and potentially opening the door to broader application.},
doi = {10.1016/j.trac.2019.04.021},
journal = {Trends in Analytical Chemistry. TrAC},
number = ,
volume = 116,
place = {United States},
year = {2019},
month = {7}
}