Opening new paths for biological applications of ion mobility - Mass spectrometry using structures for lossless ion manipulations

Journal Article · Mon Jul 01 00:00:00 EDT 2019 · Trends in Analytical Chemistry. TrAC

DOI:https://doi.org/10.1016/j.trac.2019.04.021· OSTI ID:1544781

Garimella, Venkata BS  ^[1]; Nagy, Gavril ^[1]; Ibrahim, Yehia M.  ^[1]; Smith, Richard D.  ^[1]

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1. BATTELLE (PACIFIC NW LAB)

Ion mobility separations coupled to mass spectrometry (IM-MS) have received much attention for their ability to provide complementary structural information to solution-phase-based separations, as well as to aid in the identification of unknown compounds. While IM-MS is an increasingly powerful analytical technique, significant bottlenecks related to the resolution and sensitivity of measurements have kept it from becoming broadly applied for biological analyses. Structures for Lossless Ion Manipulations (SLIM)-based IM separations have successfully overcome these aforementioned bottlenecks, addressing issues associated with resolution and sensitivity in the omics, and potentially opening the door to broader application.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1544781
• Report Number(s): PNNL-SA-140349
• Journal Information: Trends in Analytical Chemistry. TrAC, Vol. 116
• Country of Publication: United States
• Language: English