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Title: Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes

Abstract

Biological membranes reflect a fascinating example of a separation system that is multifunctional, tunable, precise, and efficient. Biomimetic membranes, which mimic the architecture of cellular membranes, have the potential to deliver significant improvements in specificity and permeability. In this work, a fully synthetic biomimetic membrane is introduced that incorporates ultra-efficient 1.5 nm diameter carbon nanotube porin (CNTPs) channels in a block-copolymer matrix. It is demonstrated that CNTPs maintain high proton and water permeability in these membranes. CNTPs can also mimic the behavior of biological gap junctions by forming bridges between vesicular compartments that allow transport of small molecules.

Authors:
 [1];  [2];  [2];  [3];  [3];  [3];  [4];  [4];  [5];  [3];  [6]; ORCiD logo [2]
  1. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Univ. of California, Davis, CA (United States)
  2. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Univ. of California Merced, Merced, CA (United States)
  3. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
  4. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  5. Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Univ. of Washington, Seattle, WA (United States)
  6. Univ. of California, Davis, CA (United States)
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA); National Institutes of Health (NIH); National Institute of General Medical Sciences
OSTI Identifier:
1542739
Alternate Identifier(s):
OSTI ID: 1479554
Report Number(s):
LLNL-JRNL-761054
Journal ID: ISSN 0935-9648; 949988
Grant/Contract Number:  
AC52-07NA27344; SCW0972; AC02‐05CH11231; AC02‐76SF00515; AC05–76RL01830; AC02-05CH11231; AC02-76SF00515
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Advanced Materials
Additional Journal Information:
Journal Volume: 30; Journal Issue: 51; Journal ID: ISSN 0935-9648
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; artificial membranes; carbon nanotube porins; carbon nanotubes; fast transport; polymersomes

Citation Formats

Sanborn, Jeremy R., Chen, Xi, Yao, Yun-Chiao, Hammons, Joshua A., Tunuguntla, Ramya H., Zhang, Yuliang, Newcomb, Christina C., Soltis, Jennifer A., De Yoreo, James J., Van Buuren, Anthony, Parikh, Atul N., and Noy, Aleksandr. Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes. United States: N. p., 2018. Web. doi:10.1002/adma.201803355.
Sanborn, Jeremy R., Chen, Xi, Yao, Yun-Chiao, Hammons, Joshua A., Tunuguntla, Ramya H., Zhang, Yuliang, Newcomb, Christina C., Soltis, Jennifer A., De Yoreo, James J., Van Buuren, Anthony, Parikh, Atul N., & Noy, Aleksandr. Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes. United States. doi:10.1002/adma.201803355.
Sanborn, Jeremy R., Chen, Xi, Yao, Yun-Chiao, Hammons, Joshua A., Tunuguntla, Ramya H., Zhang, Yuliang, Newcomb, Christina C., Soltis, Jennifer A., De Yoreo, James J., Van Buuren, Anthony, Parikh, Atul N., and Noy, Aleksandr. Wed . "Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes". United States. doi:10.1002/adma.201803355. https://www.osti.gov/servlets/purl/1542739.
@article{osti_1542739,
title = {Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes},
author = {Sanborn, Jeremy R. and Chen, Xi and Yao, Yun-Chiao and Hammons, Joshua A. and Tunuguntla, Ramya H. and Zhang, Yuliang and Newcomb, Christina C. and Soltis, Jennifer A. and De Yoreo, James J. and Van Buuren, Anthony and Parikh, Atul N. and Noy, Aleksandr},
abstractNote = {Biological membranes reflect a fascinating example of a separation system that is multifunctional, tunable, precise, and efficient. Biomimetic membranes, which mimic the architecture of cellular membranes, have the potential to deliver significant improvements in specificity and permeability. In this work, a fully synthetic biomimetic membrane is introduced that incorporates ultra-efficient 1.5 nm diameter carbon nanotube porin (CNTPs) channels in a block-copolymer matrix. It is demonstrated that CNTPs maintain high proton and water permeability in these membranes. CNTPs can also mimic the behavior of biological gap junctions by forming bridges between vesicular compartments that allow transport of small molecules.},
doi = {10.1002/adma.201803355},
journal = {Advanced Materials},
issn = {0935-9648},
number = 51,
volume = 30,
place = {United States},
year = {2018},
month = {10}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

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Cited by: 1 work
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Figures / Tables:

Figure 1 Figure 1: CNTPs in polymersome membranes. a. Schematic of the CNTP incorporation into PB-PEO 1800 polymersomes. b. Cryogenic TEM image of a polymersome wall with CNTPs. Inset highlights the location of the CNTPs in the image. c. A frame from a HS-AFM movie of the CNTP/polymersome membrane fused onto amore » mica surface. Image shows several CNTPs protruding above the polymersome membrane plane.« less

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    Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.