Microenvironment control of porphyrin binding, organization, and function in peptide nanofiber assemblies

Solomon, Lee A.; Wood, Anna R.; Sykes, Matthew E.; Diroll, Benjamin T.; Wiederrecht, Gary P.; Schaller, Richard D.; Fry, H. Christopher

doi:10.1039/c8nr09556f

Title: Microenvironment control of porphyrin binding, organization, and function in peptide nanofiber assemblies

Journal Article · Thu Mar 07 00:00:00 EST 2019 · Nanoscale

DOI:https://doi.org/10.1039/c8nr09556f· OSTI ID:1542129

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^[1]; Sykes, Matthew E. ^[1];

^[1]; Wiederrecht, Gary P. ^[1];

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Argonne National Lab. (ANL), Lemont, IL (United States). Center for Nanoscale Materials
Argonne National Lab. (ANL), Lemont, IL (United States). Center for Nanoscale Materials; Northwestern Univ., Evanston, IL (United States). Dept. of Chemistry

To take peptide materials from predominantly structural to functional assemblies, variations in cofactor binding sites must be engineered and controlled. Here, we have employed the peptide sequence c16-AHX₃K₃-CO₂H where X₃ represents the aliphatic structural component of the peptide design that dictates β-sheet formation and upon self-assembly yields a change in the overall microenvironment surrounding the Zn protoporphyrin IX ((PPIX)Zn) binding site. All peptides studied yield β-sheet rich nanofibers highlighting the materials’ resiliency to amino acid substitution. We highlight that the (PPIX)Zn binding constants correlate strongly with amino acid side chain volume, where X = L or I yields the lowest dissociation constant values (K_D). The resulting microenvironment highlights the materials’ ability to control interchromophore electronic interactions such that slip-stacked cofacial arrangements are observed via exciton splitting in UV/visible and circular dichroism spectroscopy. Steady state and time-resolved photoluminescence suggests that greater interchromophore packing yields larger excimer populations and corresponding longer excimer association lifetimes (τ_A) which directly translates to shorter exciton diffusion lengths. In comparison to synthetic porphyrin molecular assemblies, this work demonstrates the ability to employ the peptide assembly to modulate the degree of cofactor arrangement, extent of excimer formation, and the exciton hopping rates all while in a platform amenable for producing polymer-like material

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1542129

Alternate ID(s):: OSTI ID: 1498806

Journal Information:: Nanoscale, Vol. 11, Issue 12; ISSN 2040-3364

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 5 works

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