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Title: Merging roads: chemical tools and cell biology to study unconventional protein secretion


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Publication Date:
Research Org.:
Univ. of California, Riverside, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
DOE Contract Number:  
Resource Type:
Journal Article
Journal Name:
Journal of Experimental Botany
Additional Journal Information:
Journal Volume: 69; Journal Issue: 1; Journal ID: ISSN 0022-0957
Oxford University Press
Country of Publication:
United States
Plant Sciences

Citation Formats

Rodriguez-Furlan, Cecilia, Raikhel, Natasha V., and Hicks, Glenn R. Merging roads: chemical tools and cell biology to study unconventional protein secretion. United States: N. p., 2017. Web. doi:10.1093/jxb/erx261.
Rodriguez-Furlan, Cecilia, Raikhel, Natasha V., & Hicks, Glenn R. Merging roads: chemical tools and cell biology to study unconventional protein secretion. United States. doi:10.1093/jxb/erx261.
Rodriguez-Furlan, Cecilia, Raikhel, Natasha V., and Hicks, Glenn R. Mon . "Merging roads: chemical tools and cell biology to study unconventional protein secretion". United States. doi:10.1093/jxb/erx261.
title = {Merging roads: chemical tools and cell biology to study unconventional protein secretion},
author = {Rodriguez-Furlan, Cecilia and Raikhel, Natasha V. and Hicks, Glenn R.},
abstractNote = {Not provided.},
doi = {10.1093/jxb/erx261},
journal = {Journal of Experimental Botany},
issn = {0022-0957},
number = 1,
volume = 69,
place = {United States},
year = {2017},
month = {8}

Works referenced in this record:

Plant secretome: Unlocking secrets of the secreted proteins
journal, February 2010

  • Agrawal, Ganesh Kumar; Jwa, Nam-Soo; Lebrun, Marc-Henri
  • PROTEOMICS, Vol. 10, Issue 4
  • DOI: 10.1002/pmic.200900514

Large ARF guanine nucleotide exchange factors in membrane trafficking
journal, July 2008

FM-dyes as experimental probes for dissecting vesicle trafficking in living plant cells
journal, May 2004

Endocytosis restricts Arabidopsis KNOLLE syntaxin to the cell division plane during late cytokinesis
journal, December 2009

  • Boutté, Yohann; Frescatada-Rosa, Márcia; Men, Shuzhen
  • The EMBO Journal, Vol. 29, Issue 3
  • DOI: 10.1038/emboj.2009.363

Fluorescent in situ visualization of sterols in Arabidopsis roots
journal, March 2011

Vacuolar H + -ATPase Activity Is Required for Endocytic and Secretory Trafficking in Arabidopsis
journal, February 2006

  • Dettmer, Jan; Hong-Hermesdorf, Anne; Stierhof, York-Dieter
  • The Plant Cell, Vol. 18, Issue 3
  • DOI: 10.1105/tpc.105.037978

Exo70E2 is essential for exocyst subunit recruitment and EXPO formation in both plants and animals
journal, February 2014

  • Ding, Yu; Wang, Juan; Chun Lai, John Ho
  • Molecular Biology of the Cell, Vol. 25, Issue 3
  • DOI: 10.1091/mbc.E13-10-0586

Clusters of bioactive compounds target dynamic endomembrane networks in vivo
journal, October 2011

  • Drakakaki, G.; Robert, S.; Szatmari, A. -M.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 43
  • DOI: 10.1073/pnas.1108581108

Tonoplast and Soluble Vacuolar Proteins Are Targeted by Different Mechanisms.
journal, September 1993

Transport of Storage Proteins to Protein Storage Vacuoles Is Mediated by Large Precursor-Accumulating Vesicles
journal, May 1998

  • Hara-Nishimura, Ikuko; Shimada, Tomoo; Hatano, Kyoko
  • The Plant Cell, Vol. 10, Issue 5
  • DOI: 10.1105/tpc.10.5.825

Small Molecules Present Large Opportunities in Plant Biology
journal, June 2012

The trans-Golgi Network and the Golgi Stacks Behave Independently During Regeneration After Brefeldin A Treatment in Tobacco BY-2 Cells
journal, February 2017

  • Ito, Yoko; Toyooka, Kiminori; Fujimoto, Masaru
  • Plant and Cell Physiology, Vol. 58, Issue 4
  • DOI: 10.1093/pcp/pcx028

Roles for mannitol and mannitol dehydrogenase in active oxygen-mediated plant defense
journal, December 1998

  • Jennings, D. B.; Ehrenshaft, M.; Pharr, D. M.
  • Proceedings of the National Academy of Sciences, Vol. 95, Issue 25
  • DOI: 10.1073/pnas.95.25.15129

Integral Membrane Protein Sorting to Vacuoles in Plant Cells: Evidence for Two Pathways
journal, November 1998

Plant secretome — From cellular process to biological activity
journal, November 2013

  • Krause, Cornelia; Richter, Sandra; Knöll, Christian
  • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1834, Issue 11
  • DOI: 10.1016/j.bbapap.2013.03.024

Arabidopsis V-ATPase activity at the tonoplast is required for efficient nutrient storage but not for sodium accumulation
journal, January 2010

  • Krebs, M.; Beyhl, D.; Gorlich, E.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 7
  • DOI: 10.1073/pnas.0913035107

Receptor-mediated sorting of soluble vacuolar proteins ends at the trans-Golgi network/early endosome
journal, March 2016

Golgi Regeneration after Brefeldin A Treatment in BY-2 Cells Entails Stack Enlargement and Cisternal Growth followed by Division
journal, August 2007

  • Langhans, Markus; Hawes, Chris; Hillmer, Stefan
  • Plant Physiology, Vol. 145, Issue 2
  • DOI: 10.1104/pp.107.104919

Bright Ideas for Chemical Biology
journal, March 2008

  • Lavis, Luke D.; Raines, Ronald T.
  • ACS Chemical Biology, Vol. 3, Issue 3
  • DOI: 10.1021/cb700248m

Different Endomembrane Trafficking Pathways Establish Apical and Basal Polarities
journal, December 2016

  • Li, Ruixi; Rodriguez-Furlan, Cecilia; Wang, Junqi
  • The Plant Cell, Vol. 29, Issue 1
  • DOI: 10.1105/tpc.16.00524

Advances and perspectives on the use of CRISPR/Cas9 systems in plant genomics research
journal, April 2016

GNOM-LIKE1/ERMO1 and SEC24a/ERMO2 Are Required for Maintenance of Endoplasmic Reticulum Morphology in Arabidopsis thaliana
journal, November 2009

  • Nakano, Ryohei Thomas; Matsushima, Ryo; Ueda, Haruko
  • The Plant Cell, Vol. 21, Issue 11
  • DOI: 10.1105/tpc.109.068270

Brefeldin A: Deciphering an Enigmatic Inhibitor of Secretion
journal, November 2002

Harnessing the Potential of Small Molecule Intracellular Fluorescent Sensors
journal, February 2016

Identification of the Protein Storage Vacuole and Protein Targeting to the Vacuole in Leaf Cells of Three Plant Species
journal, January 2004

  • Park, Misoon; Kim, Soo Jin; Vitale, Alessandro
  • Plant Physiology, Vol. 134, Issue 2
  • DOI: 10.1104/pp.103.030635

Traffic Routes and Signals for the Tonoplast: Protein Sorting to the Tonoplast
journal, February 2013

  • Pedrazzini, Emanuela; Komarova, Nataliya Y.; Rentsch, Doris
  • Traffic, Vol. 14, Issue 6
  • DOI: 10.1111/tra.12051

Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex
journal, March 1999

Arabinogalactan Glycosyltransferases Target to a Unique Subcellular Compartment That May Function in Unconventional Secretion in Plants
journal, September 2014

  • Poulsen, Christian Peter; Dilokpimol, Adiphol; Mouille, Grégory
  • Traffic, Vol. 15, Issue 11
  • DOI: 10.1111/tra.12203

Pathways of Unconventional Protein Secretion
journal, March 2017

Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor
journal, December 2003

  • Renault, Louis; Guibert, Bernard; Cherfils, Jacqueline
  • Nature, Vol. 426, Issue 6966
  • DOI: 10.1038/nature02197

Functional diversification of closely related ARF-GEFs in protein secretion and recycling
journal, July 2007

  • Richter, Sandra; Geldner, Niko; Schrader, Jarmo
  • Nature, Vol. 448, Issue 7152
  • DOI: 10.1038/nature05967

A Small Molecule Inhibitor Partitions Two Distinct Pathways for Trafficking of Tonoplast Intrinsic Proteins in Arabidopsis
journal, September 2012

Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain
journal, August 2000

  • Robineau, S.; Chabre, M.; Antonny, B.
  • Proceedings of the National Academy of Sciences, Vol. 97, Issue 18
  • DOI: 10.1073/pnas.170290597

Unconventional protein secretion in plants: a critical assessment
journal, September 2015

BFA effects are tissue and not just plant specific
journal, August 2008

Multivesicular Bodies Mature from the Trans -Golgi Network/Early Endosome in Arabidopsis
journal, September 2011

  • Scheuring, David; Viotti, Corrado; Krüger, Falco
  • The Plant Cell, Vol. 23, Issue 9
  • DOI: 10.1105/tpc.111.086918

A Pumpkin 72-kDa Membrane Protein of Precursor-Accumulating Vesicles Has Characteristics of a Vacuolar Sorting Receptor
journal, January 1997

Two glycosylated vacuolar GFPs are new markers for ER-to-vacuole sorting
journal, December 2013

Morphogenesis of the Endoplasmic Reticulum: Beyond Active Membrane Expansion: ER Morphogenesis
journal, April 2006

Saturation-Transfer Difference (STD) NMR: A Simple and Fast Method for Ligand Screening and Characterization of Protein Binding
journal, July 2011

  • Viegas, Aldino; Manso, João; Nobrega, Franklin L.
  • Journal of Chemical Education, Vol. 88, Issue 7
  • DOI: 10.1021/ed101169t

The Endoplasmic Reticulum Is the Main Membrane Source for Biogenesis of the Lytic Vacuole in Arabidopsis
journal, September 2013

  • Viotti, Corrado; Krüger, Falco; Krebs, Melanie
  • The Plant Cell, Vol. 25, Issue 9
  • DOI: 10.1105/tpc.113.114827

Apical F-actin-regulated exocytic targeting of NtPPME1 is essential for construction and rigidity of the pollen tube cell wall
journal, August 2013

  • Wang, Hao; Zhuang, Xiaohong; Cai, Yi
  • The Plant Journal, Vol. 76, Issue 3
  • DOI: 10.1111/tpj.12300

Wortmannin induces homotypic fusion of plant prevacuolar compartments*
journal, May 2009

  • Wang, Junqi; Cai, Yi; Miao, Yansong
  • Journal of Experimental Botany, Vol. 60, Issue 11
  • DOI: 10.1093/jxb/erp136

Protein secretion in plants: conventional and unconventional pathways and new techniques
journal, August 2017

  • Wang, Xiangfeng; Chung, Kin Pan; Lin, Weili
  • Journal of Experimental Botany, Vol. 69, Issue 1
  • DOI: 10.1093/jxb/erx262

Filipin, an Antifungal Antibiotic: Isolation and Properties
journal, September 1955

  • Whitfield, George B.; Brock, Thomas D.; Ammann, Alfred
  • Journal of the American Chemical Society, Vol. 77, Issue 18
  • DOI: 10.1021/ja01623a032

Protein-binding assays in biological liquids using microscale thermophoresis
journal, October 2010

  • Wienken, Christoph J.; Baaske, Philipp; Rothbauer, Ulrich
  • Nature Communications, Vol. 1, Issue 1
  • DOI: 10.1038/ncomms1093

Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis
journal, November 2015

  • Zhang, Chunhua; Brown, Michelle Q.; van de Ven, Wilhelmina
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 1
  • DOI: 10.1073/pnas.1521248112