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Title: Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics

Abstract

Recent advances in the chemical design and synthesis of fluorophores in the second near-infrared biological window (NIR-II) for multimodal imaging and theranostics are summarized and highlighted in this review article.

Authors:
ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [2]
  1. Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province; College of Optoelectronic Engineering; Shenzhen University; Shenzhen 518060; P. R. China
  2. Molecular Imaging Program at Stanford (MIPS); Bio-X Program, and Department of Radiology; Canary Center at Stanford for Cancer Early Detection; Stanford University; Stanford
Publication Date:
Research Org.:
Stanford Univ., CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1540023
DOE Contract Number:  
SC0008397
Resource Type:
Journal Article
Journal Name:
Chemical Society Reviews
Additional Journal Information:
Journal Volume: 47; Journal Issue: 12; Journal ID: ISSN 0306-0012
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
Chemistry

Citation Formats

He, Shuqing, Song, Jun, Qu, Junle, and Cheng, Zhen. Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics. United States: N. p., 2018. Web. doi:10.1039/c8cs00234g.
He, Shuqing, Song, Jun, Qu, Junle, & Cheng, Zhen. Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics. United States. doi:10.1039/c8cs00234g.
He, Shuqing, Song, Jun, Qu, Junle, and Cheng, Zhen. Mon . "Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics". United States. doi:10.1039/c8cs00234g.
@article{osti_1540023,
title = {Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics},
author = {He, Shuqing and Song, Jun and Qu, Junle and Cheng, Zhen},
abstractNote = {Recent advances in the chemical design and synthesis of fluorophores in the second near-infrared biological window (NIR-II) for multimodal imaging and theranostics are summarized and highlighted in this review article.},
doi = {10.1039/c8cs00234g},
journal = {Chemical Society Reviews},
issn = {0306-0012},
number = 12,
volume = 47,
place = {United States},
year = {2018},
month = {1}
}

Works referenced in this record:

Exploiting the biological windows: current perspectives on fluorescent bioprobes emitting above 1000 nm
journal, January 2016

  • Hemmer, Eva; Benayas, Antonio; Légaré, François
  • Nanoscale Horizons, Vol. 1, Issue 3
  • DOI: 10.1039/C5NH00073D

Near-infrared fluorophores for biomedical imaging
journal, January 2017

  • Hong, Guosong; Antaris, Alexander L.; Dai, Hongjie
  • Nature Biomedical Engineering, Vol. 1, Issue 1
  • DOI: 10.1038/s41551-016-0010

Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe
journal, April 2017

  • Shou, Kangquan; Qu, Chunrong; Sun, Yao
  • Advanced Functional Materials, Vol. 27, Issue 23
  • DOI: 10.1002/adfm.201700995

A small-molecule dye for NIR-II imaging
journal, November 2015

  • Antaris, Alexander L.; Chen, Hao; Cheng, Kai
  • Nature Materials, Vol. 15, Issue 2
  • DOI: 10.1038/nmat4476

Rare-earth-doped biological composites as in vivo shortwave infrared reporters
journal, July 2013

  • Naczynski, D. J.; Tan, M. C.; Zevon, M.
  • Nature Communications, Vol. 4, Issue 1
  • DOI: 10.1038/ncomms3199

A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
journal, October 2009

  • Welsher, Kevin; Liu, Zhuang; Sherlock, Sarah P.
  • Nature Nanotechnology, Vol. 4, Issue 11
  • DOI: 10.1038/nnano.2009.294

Indocyanine green fluorescence in second near-infrared (NIR-II) window
journal, November 2017


Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green
journal, April 2018

  • Carr, Jessica A.; Franke, Daniel; Caram, Justin R.
  • Proceedings of the National Academy of Sciences, Vol. 115, Issue 17
  • DOI: 10.1073/pnas.1718917115

A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging
journal, May 2017

  • Antaris, Alexander L.; Chen, Hao; Diao, Shuo
  • Nature Communications, Vol. 8, Issue 1
  • DOI: 10.1038/ncomms15269

Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer
journal, January 2016

  • Sun, Yao; Qu, Chunrong; Chen, Hao
  • Chemical Science, Vol. 7, Issue 9
  • DOI: 10.1039/C6SC01561A

Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery
journal, January 2018

  • Sun, Yao; Zeng, Xiaodong; Xiao, Yuling
  • Chemical Science, Vol. 9, Issue 8
  • DOI: 10.1039/C7SC04774F

Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore
journal, June 2016

  • Zhang, Xiao-Dong; Wang, Huasen; Antaris, Alexander L.
  • Advanced Materials, Vol. 28, Issue 32
  • DOI: 10.1002/adma.201600706

Molecular imaging of biological systems with a clickable dye in the broad 800- to 1,700-nm near-infrared window
journal, January 2017

  • Zhu, Shoujun; Yang, Qinglai; Antaris, Alexander L.
  • Proceedings of the National Academy of Sciences, Vol. 114, Issue 5
  • DOI: 10.1073/pnas.1617990114

Live imaging of follicle stimulating hormone receptors in gonads and bones using near infrared II fluorophore
journal, January 2017

  • Feng, Yi; Zhu, Shoujun; Antaris, Alexander L.
  • Chemical Science, Vol. 8, Issue 5
  • DOI: 10.1039/C6SC04897H

Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery
journal, January 2017

  • Sun, Yao; Ding, Mingmin; Zeng, Xiaodong
  • Chemical Science, Vol. 8, Issue 5
  • DOI: 10.1039/C7SC00251C

Biological Imaging Using Nanoparticles of Small Organic Molecules with Fluorescence Emission at Wavelengths Longer than 1000 nm
journal, October 2013

  • Tao, Zhimin; Hong, Guosong; Shinji, Chihiro
  • Angewandte Chemie International Edition, Vol. 52, Issue 49
  • DOI: 10.1002/anie.201307346

Ultrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window
journal, June 2014

  • Hong, Guosong; Zou, Yingping; Antaris, Alexander L.
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms5206

In Vivo Fluorescence Imaging with Ag 2 S Quantum Dots in the Second Near-Infrared Region
journal, September 2012

  • Hong, Guosong; Robinson, Joshua T.; Zhang, Yejun
  • Angewandte Chemie, Vol. 124, Issue 39
  • DOI: 10.1002/ange.201206059

Tracking of Transplanted Human Mesenchymal Stem Cells in Living Mice using Near-Infrared Ag 2 S Quantum Dots
journal, December 2013

  • Chen, Guangcun; Tian, Fei; Zhang, Yan
  • Advanced Functional Materials, Vol. 24, Issue 17
  • DOI: 10.1002/adfm.201303263

Near-infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate)
journal, January 2011

  • Kamimura, Masao; Kanayama, Naoki; Tokuzen, Kimikazu
  • Nanoscale, Vol. 3, Issue 9
  • DOI: 10.1039/c1nr10466g

CXCR-4 Targeted, Short Wave Infrared (SWIR) Emitting Nanoprobes for Enhanced Deep Tissue Imaging and Micrometastatic Cancer Lesion Detection
journal, October 2015


Tunable Narrow Band Emissions from Dye-Sensitized Core/Shell/Shell Nanocrystals in the Second Near-Infrared Biological Window
journal, December 2016

  • Shao, Wei; Chen, Guanying; Kuzmin, Andrey
  • Journal of the American Chemical Society, Vol. 138, Issue 50
  • DOI: 10.1021/jacs.6b08973

In Vivo Fluorescence Imaging in the Second Near-Infrared Window with Long Circulating Carbon Nanotubes Capable of Ultrahigh Tumor Uptake
journal, June 2012

  • Robinson, Joshua T.; Hong, Guosong; Liang, Yongye
  • Journal of the American Chemical Society, Vol. 134, Issue 25
  • DOI: 10.1021/ja303737a

Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window
journal, May 2011

  • Welsher, K.; Sherlock, S. P.; Dai, H.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 22
  • DOI: 10.1073/pnas.1014501108

Multifunctional in vivo vascular imaging using near-infrared II fluorescence
journal, November 2012

  • Hong, Guosong; Lee, Jerry C.; Robinson, Joshua T.
  • Nature Medicine, Vol. 18, Issue 12
  • DOI: 10.1038/nm.2995

Through-skull fluorescence imaging of the brain in a new near-infrared window
journal, August 2014


Industrial-scale separation of high-purity single-chirality single-wall carbon nanotubes for biological imaging
journal, June 2016

  • Yomogida, Yohei; Tanaka, Takeshi; Zhang, Minfang
  • Nature Communications, Vol. 7, Issue 1
  • DOI: 10.1038/ncomms12056

Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm
journal, October 2015

  • Diao, Shuo; Blackburn, Jeffrey L.; Hong, Guosong
  • Angewandte Chemie International Edition, Vol. 54, Issue 49
  • DOI: 10.1002/anie.201507473

In vivo biosensing via tissue-localizable near-infrared-fluorescent single-walled carbon nanotubes
journal, November 2013

  • Iverson, Nicole M.; Barone, Paul W.; Shandell, Mia
  • Nature Nanotechnology, Vol. 8, Issue 11
  • DOI: 10.1038/nnano.2013.222

X-ray-Induced Shortwave Infrared Biomedical Imaging Using Rare-Earth Nanoprobes
journal, December 2014

  • Naczynski, Dominik Jan; Sun, Conroy; Türkcan, Silvan
  • Nano Letters, Vol. 15, Issue 1
  • DOI: 10.1021/nl504123r

Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes
journal, September 2014

  • Ghosh, D.; Bagley, A. F.; Na, Y. J.
  • Proceedings of the National Academy of Sciences, Vol. 111, Issue 38
  • DOI: 10.1073/pnas.1400821111

Size and Shell Effects on the Photoacoustic and Luminescence Properties of Dual Modal Rare-Earth-Doped Nanoparticles for Infrared Photoacoustic Imaging
journal, April 2016


Multimodal Biomedical Imaging with Asymmetric Single-Walled Carbon Nanotube/Iron Oxide Nanoparticle Complexes
journal, April 2007

  • Choi, Jong Hyun; Nguyen, Freddy T.; Barone, Paul W.
  • Nano Letters, Vol. 7, Issue 4
  • DOI: 10.1021/nl062306v

A novel photoacoustic nanoprobe of ICG@PEG-Ag 2 S for atherosclerosis targeting and imaging in vivo
journal, January 2016


Highly Efficient NIR-II Photothermal Conversion Based on an Organic Conjugated Polymer
journal, December 2016


Surface Plasmon Resonance Enhanced Light Absorption and Photothermal Therapy in the Second Near-Infrared Window
journal, October 2014

  • Ding, Xianguang; Liow, Chi Hao; Zhang, Mengxin
  • Journal of the American Chemical Society, Vol. 136, Issue 44
  • DOI: 10.1021/ja508641z

A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows
journal, November 2017

  • Lin, Han; Gao, Shanshan; Dai, Chen
  • Journal of the American Chemical Society, Vol. 139, Issue 45
  • DOI: 10.1021/jacs.7b07818

Hybrid Nanostructures for High-Sensitivity Luminescence Nanothermometry in the Second Biological Window
journal, July 2015

  • Cerón, Elizabeth Navarro; Ortgies, Dirk H.; del Rosal, Blanca
  • Advanced Materials, Vol. 27, Issue 32
  • DOI: 10.1002/adma.201501014

Designing Multi-Branched Gold Nanoechinus for NIR Light Activated Dual Modal Photodynamic and Photothermal Therapy in the Second Biological Window
journal, July 2014

  • Vijayaraghavan, Priya; Liu, Cheng-Hong; Vankayala, Raviraj
  • Advanced Materials, Vol. 26, Issue 39
  • DOI: 10.1002/adma.201400703

Real-time in vivo visualization of tumor therapy by a near-infrared-II Ag2S quantum dot-based theranostic nanoplatform
journal, April 2015