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Title: Chemistry and radiochemistry of As, Re and Rh isotopes relevant to radiopharmaceutical applications: high specific activity radionuclides for imaging and treatment

Abstract

Advances in production, separation, target recovery, and chelation chemistry of high specific activity radionuclides will promote new theranostic agent development.

Authors:
 [1];  [1];  [1];  [2];  [3];  [3];  [1];  [4]; ORCiD logo [4]; ORCiD logo [1]
  1. Department of Chemistry; University of Missouri; Columbia; USA
  2. Structural Biology Core; University of Missouri; Columbia; USA
  3. Research Division; Harry S. Truman Memorial Veterans’ Hospital; Columbia; USA
  4. University of Missouri Research Reactor Center (MURR); University of Missouri; Columbia; USA
Publication Date:
Research Org.:
Univ. of Missouri, Columbia, MO (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1539911
DOE Contract Number:  
SC0003851; SC0007348; SC0010283
Resource Type:
Journal Article
Journal Name:
Dalton Transactions
Additional Journal Information:
Journal Volume: 46; Journal Issue: 42; Journal ID: ISSN 1477-9226
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
Chemistry

Citation Formats

Feng, Yutian, Phelps, Tim E., Carroll, Valerie, Gallazzi, Fabio, Sieckman, Gary, Hoffman, Timothy J., Barnes, Charles L., Ketring, Alan R., Hennkens, Heather M., and Jurisson, Silvia S. Chemistry and radiochemistry of As, Re and Rh isotopes relevant to radiopharmaceutical applications: high specific activity radionuclides for imaging and treatment. United States: N. p., 2017. Web. doi:10.1039/c7dt02407j.
Feng, Yutian, Phelps, Tim E., Carroll, Valerie, Gallazzi, Fabio, Sieckman, Gary, Hoffman, Timothy J., Barnes, Charles L., Ketring, Alan R., Hennkens, Heather M., & Jurisson, Silvia S. Chemistry and radiochemistry of As, Re and Rh isotopes relevant to radiopharmaceutical applications: high specific activity radionuclides for imaging and treatment. United States. doi:10.1039/c7dt02407j.
Feng, Yutian, Phelps, Tim E., Carroll, Valerie, Gallazzi, Fabio, Sieckman, Gary, Hoffman, Timothy J., Barnes, Charles L., Ketring, Alan R., Hennkens, Heather M., and Jurisson, Silvia S. Sun . "Chemistry and radiochemistry of As, Re and Rh isotopes relevant to radiopharmaceutical applications: high specific activity radionuclides for imaging and treatment". United States. doi:10.1039/c7dt02407j.
@article{osti_1539911,
title = {Chemistry and radiochemistry of As, Re and Rh isotopes relevant to radiopharmaceutical applications: high specific activity radionuclides for imaging and treatment},
author = {Feng, Yutian and Phelps, Tim E. and Carroll, Valerie and Gallazzi, Fabio and Sieckman, Gary and Hoffman, Timothy J. and Barnes, Charles L. and Ketring, Alan R. and Hennkens, Heather M. and Jurisson, Silvia S.},
abstractNote = {Advances in production, separation, target recovery, and chelation chemistry of high specific activity radionuclides will promote new theranostic agent development.},
doi = {10.1039/c7dt02407j},
journal = {Dalton Transactions},
issn = {1477-9226},
number = 42,
volume = 46,
place = {United States},
year = {2017},
month = {1}
}

Works referenced in this record:

Radium: A Miracle Cure!
journal, October 1998


RADIOACTIVE IODINE THERAPY: Effect on Functioning Metastases of Adenocarcinoma of the Thyroid
journal, December 1946


Technetium, the missing element
journal, March 1996

  • de Jonge, Frederik A. A.; Pauwels, Ernest K. J.
  • European Journal of Nuclear Medicine, Vol. 23, Issue 3
  • DOI: 10.1007/BF00837634

Technetium-99m: An historical perspective
journal, October 1982

  • Richards, Powell; Tucker, Walter D.; Srivastava, Suresh C.
  • The International Journal of Applied Radiation and Isotopes, Vol. 33, Issue 10
  • DOI: 10.1016/0020-708X(82)90120-X

99mTc-propylene amine oxime (99mTc-PnAO); a potential brain radiopharmaceutical
journal, November 1984

  • Volkert, W. A.; Hoffman, T. J.; Seger, R. M.
  • European Journal of Nuclear Medicine, Vol. 9, Issue 11
  • DOI: 10.1007/BF00263256

Potential Technetium Small Molecule Radiopharmaceuticals
journal, September 1999

  • Jurisson, Silvia S.; Lydon, John D.
  • Chemical Reviews, Vol. 99, Issue 9
  • DOI: 10.1021/cr980435t

Therapeutic Radiopharmaceuticals
journal, September 1999

  • Volkert, Wynn A.; Hoffman, Timothy J.
  • Chemical Reviews, Vol. 99, Issue 9
  • DOI: 10.1021/cr9804386

Yttrium-90 Microspheres: A Review of Its Emerging Clinical Indications
journal, December 2014

  • Khajornjiraphan, Natthida; Thu, Nyein Aye; Chow, Pierce Kah Hoe
  • Liver Cancer, Vol. 4, Issue 1
  • DOI: 10.1159/000343876

Radiometals for Combined Imaging and Therapy
journal, October 2012

  • Cutler, Cathy S.; Hennkens, Heather M.; Sisay, Nebiat
  • Chemical Reviews, Vol. 113, Issue 2, p. 858-883
  • DOI: 10.1021/cr3003104

Radioimmunoimaging with Longer-Lived Positron-Emitting Radionuclides: Potentials and Challenges
journal, May 2009

  • Nayak, Tapan K.; Brechbiel, Martin W.
  • Bioconjugate Chemistry, Vol. 20, Issue 5
  • DOI: 10.1021/bc800299f

Chromatographic separation of germanium and arsenic for the production of high purity 77As
journal, April 2016


Chromatographic separation of selenium and arsenic: A potential 72Se/72As generator
journal, May 2014


Selenium-72 formation via natBr(p,x) induced by 100MeV Protons: Steps towards a novel 72Se/72As generator system
journal, April 2012


Separation and purification of no-carrier-added arsenic from bulk amounts of germanium for use in radiopharmaceutical labelling
journal, January 2010


A new method for radiochemical separation of arsenic from irradiated germanium oxide
journal, September 2005


An isotope generator for 72As
journal, November 1978

  • Al-Kouraishi, S. H.; Boswell, G. G. J.
  • The International Journal of Applied Radiation and Isotopes, Vol. 29, Issue 11
  • DOI: 10.1016/0020-708X(78)90093-5

A new method for the labelling of proteins with radioactive arsenic isotopes
journal, December 2006

  • Jennewein, M.; Hermanne, A.; Mason, R. P.
  • Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 569, Issue 2
  • DOI: 10.1016/j.nima.2006.08.088

Vascular Imaging of Solid Tumors in Rats with a Radioactive Arsenic-Labeled Antibody that Binds Exposed Phosphatidylserine
journal, March 2008


72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging
journal, September 2010

  • Herth, Matthias M.; Barz, Matthias; Jahn, Markus
  • Bioorganic & Medicinal Chemistry Letters, Vol. 20, Issue 18
  • DOI: 10.1016/j.bmcl.2010.07.092

Dithiol Aryl Arsenic Compounds as Potential Diagnostic and Therapeutic Radiopharmaceuticals
journal, July 2016


Trithiols and their arsenic compounds for potential use in diagnostic and therapeutic radiopharmaceuticals
journal, May 2016


The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity
journal, March 2008


264. Infrared spectra (1000—200 cm. –1 )of some transition-metal complexes with tertiary arsine oxides
journal, January 1965

  • Rodley, G. A.; Goodgame, D. M. L.; Cotton, F. A.
  • J. Chem. Soc., Vol. 0, Issue 0
  • DOI: 10.1039/JR9650001499

The chemistry of rhenium and technetium as related to the use of isotopes of these elements in therapeutic and diagnostic nuclear medicine
journal, January 1986

  • Deutsch, Edward; Libson, Karen; Vanderheyden, Jean-Luc
  • International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 13, Issue 4
  • DOI: 10.1016/0883-2897(86)90027-9

Experience with aluminum perrhenate targets for reactor production of high specific activity Re-186
journal, January 1997


Separation of Clinical Grade 188Re from 188W Using Polymer Embedded Nanocrystalline Titania
journal, March 2009


Production of no-carrier-added 186Re via deuteron induced reactions on isotopically enriched 186W
journal, January 2001


Production study of high specific activity NCA Re-186g by proton and deuteron cyclotron irradiation
journal, September 2010


Deuteron irradiation of W and WO3 for production of high specific activity 186Re: Challenges associated with thick target preparation
journal, September 2016


Bulk production and evaluation of high specific activity 186gRe for cancer therapy using enriched 186WO3 targets in a proton beam
journal, June 2017


Production and separation of 186gRe from proton bombardment of 186WC
journal, June 2015


Production cross-sections of 181–186Re isotopes from proton bombardment of natural tungsten
journal, March 2007


New measurement and evaluation of the excitation function of the 186W(p,n) nuclear reaction for production of the therapeutic radioisotope 186Re
journal, November 2007

  • Tárkányi, F.; Hermanne, A.; Takács, S.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 264, Issue 2
  • DOI: 10.1016/j.nimb.2007.09.026

Production method of no-carrier-added186Re
journal, April 1996

  • Shigeta, N.; Matsuoka, H.; Osa, A.
  • Journal of Radioanalytical and Nuclear Chemistry Articles, Vol. 205, Issue 1
  • DOI: 10.1007/BF02040553

Thermal Conductivity Measurement of Tungsten Oxide Nanoscale Thin Films
journal, January 2006


On the reduction of tungsten blue oxide in a stream of hydrogen
journal, January 1996

  • Lackner, Andreas; Filzwieser, Andreas; Paschen, Peter
  • International Journal of Refractory Metals and Hard Materials, Vol. 14, Issue 5-6
  • DOI: 10.1016/S0263-4368(96)00008-X

Thermal conductivity determination of suspended mono- and bilayer WS2 by Raman spectroscopy
journal, November 2014


Accelerator-based production of the 99mTc-186Re diagnostic-therapeutic pair using metal disulfide targets (MoS2, WS2, OsS2)
journal, August 2016


SRIM – The stopping and range of ions in matter (2010)
journal, June 2010

  • Ziegler, James F.; Ziegler, M. D.; Biersack, J. P.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 268, Issue 11-12
  • DOI: 10.1016/j.nimb.2010.02.091

Radiochemical Study of Re/W Adsorption Behavior on a Strongly Basic Anion Exchange Resin
journal, January 2014

  • Gott, Matthew D.; Ballard, Beau D.; Redman, Lindsay N.
  • Radiochimica Acta, Vol. 102, Issue 4
  • DOI: 10.1515/ract-2013-2144

Production possibility of 186Re via the 192Os(p,α3n)186Re nuclear reaction
journal, July 2009

  • Szelecsényi, F.; Steyn, G. F.; Kovács, Z.
  • Journal of Radioanalytical and Nuclear Chemistry, Vol. 282, Issue 1
  • DOI: 10.1007/s10967-009-0147-y

Preparation of thin osmium targets by electrodeposition
journal, March 2001

  • Chakrabarty, S.; Tomar, B. S.; Goswami, A.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 174, Issue 1-2
  • DOI: 10.1016/S0168-583X(00)00509-7

Monooxorhenium(V) complexes with 222-N2S2 MAMA ligands for bifunctional chelator agents: Syntheses and preliminary in vivo evaluation
journal, December 2016


Design and characterization of  -melanotropin peptide analogs cyclized through rhenium and technetium metal coordination
journal, October 1998

  • Giblin, M. F.; Wang, N.; Hoffman, T. J.
  • Proceedings of the National Academy of Sciences, Vol. 95, Issue 22
  • DOI: 10.1073/pnas.95.22.12814

In vivo evaluation of 99mTc/188Re-labeled linear alpha-melanocyte stimulating hormone analogs for specific melanoma targeting
journal, August 1999


Preparation of cyclotron-produced 186Re and comparison with reactor-produced 186Re and generator-produced 188Re for the labeling of bombesin
journal, January 2006


105Rh as a potential radiotherapeutic agent
journal, January 1988

  • Grazman, B.; Troutner, D. E.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 39, Issue 3
  • DOI: 10.1016/0883-2889(88)90181-5

Production parameters of the therapeutic 105 Rh radionuclide using medium energy cyclotron
journal, July 2012


An Rh-105 complex of tetrathiacyclohexadecane diol with potential for formulating bifunctional chelates
journal, January 1996


A gravimetric method for the determination of ruthenium
journal, December 1929


Spectrophotometric Determination of Ruthenium
journal, February 1959


Thermal decomposition of rhodium, iridium, and ruthenium chlorides
journal, August 1968


Labeling of proteins with 105Rh
journal, January 1989

  • John, C. S.; Pillai, M. R. A.; Lo, J. M.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 40, Issue 8
  • DOI: 10.1016/0883-2889(89)90081-6

Labeling of human IgG with rhodium-105 using a new pentadentate bifunctional ligand
journal, May 1990

  • Pillai, M. R. A.; John, C. S.; Troutner, David E.
  • Bioconjugate Chemistry, Vol. 1, Issue 3
  • DOI: 10.1021/bc00003a003

Labeling of hematoporphyrin with 105Rh and binding studies with human gamma globulin
journal, January 1990

  • Pillai, M. R. A.; Lo, J. M.; Troutner, D. E.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 41, Issue 1
  • DOI: 10.1016/0883-2889(90)90132-Z

Labeling of human serum albumin with 105Rhcysteine complexes
journal, January 1990

  • Lo, J. M.; Pillai, M. R. A.; John, C. S.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 41, Issue 1
  • DOI: 10.1016/0883-2889(90)90131-Y

Comparisons of 105Rh(III) Chloride Complexation with [14]aneNS3, [14]aneN2S2 and [14]aneN4 Macrocycles in Aqueous Solution
journal, January 1996


Biodistribution of model 105Rh-labeled tetradentate thiamacrocycles in rats
journal, January 1997


Rhodium(III) Complexes with Acyclic Tetrathioether Ligands. Effects of Backbone Chain Length on the Conformation of the Rh(III) Complex
journal, January 1996

  • Goswami, Niranjan; Alberto, Roger; Barnes, Charles L.
  • Inorganic Chemistry, Vol. 35, Issue 26
  • DOI: 10.1021/ic960952z

Rhodium-105 tetrathioether complexes: radiochemistry and initial biological evaluation
journal, November 1999


The complexation of rhodium(iii) with acyclic diaminedithioether (DADTE) ligands
journal, January 2010

  • Akgun, Zeynep; Engelbrecht, Hendrik; Fan, Kuo-Hsien
  • Dalton Transactions, Vol. 39, Issue 42
  • DOI: 10.1039/c0dt00813c

241. Complexes of rhodium(III) with chlorine and pyridine
journal, January 1964


Catalysis of Substitution Reactions of Rhodium(III) Complexes. The Reaction of Aquopentachlororhodate(III) Ion with Pyridine
journal, May 1964

  • Rund, John V.; Basolo, Fred; Pearson, Ralph G.
  • Inorganic Chemistry, Vol. 3, Issue 5
  • DOI: 10.1021/ic50015a011

Polarography of some rhodium(III) complexes
journal, January 1973

  • Addison, A. W.; Gillard, R. D.; Vaughan, D. H.
  • Journal of the Chemical Society, Dalton Transactions, Issue 11
  • DOI: 10.1039/dt9730001187

A 99m Tc(I)-Postlabeled High Affinity Bombesin Analogue as a Potential Tumor Imaging Agent
journal, May 2002

  • La Bella, ; Garcia-Garayoa, E.
  • Bioconjugate Chemistry, Vol. 13, Issue 3
  • DOI: 10.1021/bc015571a

In vitro and in vivo evaluation of a 99mTc(I)-labeled bombesin analogue for imaging of gastrin releasing peptide receptor-positive tumors
journal, July 2002


99mTc(CO)3-DTMA bombesin conjugates having high affinity for the GRP receptor
journal, April 2008


MicroPET Imaging of a Gastrin-Releasing Peptide Receptor-Positive Tumor in a Mouse Model of Human Prostate Cancer Using a 64 Cu-Labeled Bombesin Analogue
journal, July 2003

  • Rogers, Buck E.; Bigott, Heather M.; McCarthy, Deborah W.
  • Bioconjugate Chemistry, Vol. 14, Issue 4
  • DOI: 10.1021/bc034018l

Potent Bombesin-like Peptides for GRP-Receptor Targeting of Tumors with 99m Tc:  A Preclinical Study
journal, January 2005

  • Nock, Berthold A.; Nikolopoulou, Anastasia; Galanis, Athanassios
  • Journal of Medicinal Chemistry, Vol. 48, Issue 1
  • DOI: 10.1021/jm049437y