skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: G-Quartet hydrogels for effective cell growth applications

Abstract

Functional G-quartet hydrogels formed from natural guanosine cross linked with benzene-1,4-diboronic acid and Mg 2+support cell growth with no visible signs of gel degradation.

Authors:
ORCiD logo [1];  [1];  [2];  [1];  [1]; ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [3]
  1. “Petru Poni” Institute of Macromolecular Chemistry; Centre Advanced Research in Bionanoconjugates and Biopolymers; Romania
  2. Department of Chemistry and Biochemistry; University of Maryland; College Park; USA
  3. “Petru Poni” Institute of Macromolecular Chemistry; Centre Advanced Research in Bionanoconjugates and Biopolymers; Romania; Institut Europeen Membranes; Adaptive Supramolecular Nanosystems Group
Publication Date:
Research Org.:
Univ. of Maryland, College Park, MD (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1539867
DOE Contract Number:  
FG02-98ER14888
Resource Type:
Journal Article
Journal Name:
ChemComm
Additional Journal Information:
Journal Volume: 53; Journal Issue: 94; Journal ID: ISSN 1359-7345
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
Chemistry

Citation Formats

Rotaru, Alexandru, Pricope, Gabriela, Plank, Taylor N., Clima, Lilia, Ursu, Elena L., Pinteala, Mariana, Davis, Jeffery T., and Barboiu, Mihail. G-Quartet hydrogels for effective cell growth applications. United States: N. p., 2017. Web. doi:10.1039/c7cc07806d.
Rotaru, Alexandru, Pricope, Gabriela, Plank, Taylor N., Clima, Lilia, Ursu, Elena L., Pinteala, Mariana, Davis, Jeffery T., & Barboiu, Mihail. G-Quartet hydrogels for effective cell growth applications. United States. doi:10.1039/c7cc07806d.
Rotaru, Alexandru, Pricope, Gabriela, Plank, Taylor N., Clima, Lilia, Ursu, Elena L., Pinteala, Mariana, Davis, Jeffery T., and Barboiu, Mihail. Sun . "G-Quartet hydrogels for effective cell growth applications". United States. doi:10.1039/c7cc07806d.
@article{osti_1539867,
title = {G-Quartet hydrogels for effective cell growth applications},
author = {Rotaru, Alexandru and Pricope, Gabriela and Plank, Taylor N. and Clima, Lilia and Ursu, Elena L. and Pinteala, Mariana and Davis, Jeffery T. and Barboiu, Mihail},
abstractNote = {Functional G-quartet hydrogels formed from natural guanosine cross linked with benzene-1,4-diboronic acid and Mg2+support cell growth with no visible signs of gel degradation.},
doi = {10.1039/c7cc07806d},
journal = {ChemComm},
issn = {1359-7345},
number = 94,
volume = 53,
place = {United States},
year = {2017},
month = {1}
}

Works referenced in this record:

From supramolecular chemistry towards constitutional dynamic chemistry and adaptive chemistry
journal, January 2007


Dynamic interactive systems: dynamic selection in hybrid organic–inorganic constitutional networks
journal, January 2010


Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
journal, December 2015


Characterization of supramolecular gels
journal, January 2013

  • Yu, Guocan; Yan, Xuzhou; Han, Chengyou
  • Chemical Society Reviews, Vol. 42, Issue 16
  • DOI: 10.1039/c3cs60080g

Supramolecular gels formed from multi-component low molecular weight species
journal, January 2012

  • Buerkle, Lauren E.; Rowan, Stuart J.
  • Chemical Society Reviews, Vol. 41, Issue 18
  • DOI: 10.1039/c2cs35106d

Supramolecular gels made from nucleobase, nucleoside and nucleotide analogs
journal, January 2016

  • Peters, Gretchen Marie; Davis, Jeffery T.
  • Chemical Society Reviews, Vol. 45, Issue 11
  • DOI: 10.1039/C6CS00183A

G-Quartets 40 Years Later: From 5′-GMP to Molecular Biology and Supramolecular Chemistry
journal, January 2004


Functional architectures derived from guanine quartets
journal, January 2016

  • Dash, Jyotirmayee; Saha, Puja
  • Organic & Biomolecular Chemistry, Vol. 14, Issue 7
  • DOI: 10.1039/C5OB02464A

Supramolecular self-organization in constitutional hybrid materials
journal, January 2009

  • Mihai, Simona; Cazacu, Adinela; Arnal-Herault, Carole
  • New Journal of Chemistry, Vol. 33, Issue 11
  • DOI: 10.1039/b908641m

Sol–gel selection of hybrid G-quadruplex architectures from dynamic supramolecular guanosine libraries
journal, January 2010

  • Mihai, Simona; Le Duc, Yann; Cot, Didier
  • Journal of Materials Chemistry, Vol. 20, Issue 42
  • DOI: 10.1039/c0jm01248c

Gelation-driven component selection in the generation of constitutional dynamic hydrogels based on guanine-quartet formation
journal, April 2005

  • Sreenivasachary, N.; Lehn, J. -M.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 17
  • DOI: 10.1073/pnas.0501663102

Efficient Self-Assembly in Water of Long Noncovalent Polymers by Nucleobase Analogues
journal, February 2013

  • Cafferty, Brian J.; Gállego, Isaac; Chen, Michael C.
  • Journal of the American Chemical Society, Vol. 135, Issue 7
  • DOI: 10.1021/ja312155v

Tunable Thermoassociation of Binary Guanosine Gels
journal, January 2008

  • Yu, Yuehua; Nakamura, Darren; DeBoyace, Kevin
  • The Journal of Physical Chemistry B, Vol. 112, Issue 4
  • DOI: 10.1021/jp709613p

Tailoring the Properties of Guanosine-Based Supramolecular Hydrogels
journal, August 2009

  • Buerkle, Lauren E.; Li, Zheng; Jamieson, Alexander M.
  • Langmuir, Vol. 25, Issue 15
  • DOI: 10.1021/la900746w

Diffusion and Birefringence of Bioactive Dyes in a Supramolecular Guanosine Hydrogel
journal, March 2012

  • Das, Rabindra Nath; Kumar, Y. Pavan; Pagoti, Sreenivasarao
  • Chemistry - A European Journal, Vol. 18, Issue 19
  • DOI: 10.1002/chem.201103814

Self-assembly of guanosine and deoxy-guanosine into hydrogels: monovalent cation guided modulation of gelation, morphology and self-healing properties
journal, January 2014

  • Adhikari, Bimalendu; Shah, Afzal; Kraatz, Heinz-Bernhard
  • J. Mater. Chem. B, Vol. 2, Issue 30
  • DOI: 10.1039/C4TB00702F

Guanosine-5′-Monophosphate Polyamine Hybrid Hydrogels: Enhanced Gel Strength Probed by z -Spectroscopy
journal, May 2017

  • Belda, Raquel; García-España, Enrique; Morris, Gareth A.
  • Chemistry - A European Journal, Vol. 23, Issue 32
  • DOI: 10.1002/chem.201700642

Supramolecular Hydrogel Inspired from DNA Structures Mimics Peroxidase Activity
journal, September 2017


Supramolecular biomaterials
journal, December 2015

  • Webber, Matthew J.; Appel, Eric A.; Meijer, E. W.
  • Nature Materials, Vol. 15, Issue 1
  • DOI: 10.1038/nmat4474

Design Strategies of Stimuli-Responsive Supramolecular Hydrogels Relying on Structural Analyses and Cell-Mimicking Approaches
journal, February 2017


Bioinspired assembly of small molecules in cell milieu
journal, January 2017

  • Wang, Huaimin; Feng, Zhaoqianqi; Xu, Bing
  • Chemical Society Reviews, Vol. 46, Issue 9
  • DOI: 10.1039/C6CS00656F

Toward potential supramolecular tissue engineering scaffolds based on guanosine derivatives
journal, January 2012

  • Buerkle, Lauren E.; von Recum, Horst A.; Rowan, Stuart J.
  • Chem. Sci., Vol. 3, Issue 2
  • DOI: 10.1039/C1SC00729G

A G 4 ·K + Hydrogel Stabilized by an Anion
journal, August 2014

  • Peters, Gretchen Marie; Skala, Luke P.; Plank, Taylor N.
  • Journal of the American Chemical Society, Vol. 136, Issue 36
  • DOI: 10.1021/ja507506c

G4-Quartet·M + Borate Hydrogels
journal, April 2015

  • Peters, Gretchen Marie; Skala, Luke P.; Plank, Taylor N.
  • Journal of the American Chemical Society, Vol. 137, Issue 17
  • DOI: 10.1021/jacs.5b02753

A Molecular Chaperone for G4-Quartet Hydrogels
journal, December 2015

  • Peters, Gretchen Marie; Skala, Luke P.; Davis, Jeffery T.
  • Journal of the American Chemical Society, Vol. 138, Issue 1
  • DOI: 10.1021/jacs.5b08769

A G 4 ·K + hydrogel that self-destructs
journal, January 2016

  • Plank, Taylor N.; Davis, Jeffery T.
  • Chemical Communications, Vol. 52, Issue 28
  • DOI: 10.1039/C6CC01494A

Supramolecular Photoactivatable Anticancer Hydrogels
journal, April 2017

  • Venkatesh, V.; Mishra, Narendra Kumar; Romero-Canelón, Isolda
  • Journal of the American Chemical Society, Vol. 139, Issue 16
  • DOI: 10.1021/jacs.7b00186

Boronic acid building blocks: tools for self assembly
journal, January 2011

  • Nishiyabu, Ryuhei; Kubo, Yuji; James, Tony D.
  • Chem. Commun., Vol. 47, Issue 4
  • DOI: 10.1039/C0CC02921A

Boronic acid-containing hydrogels: synthesis and their applications
journal, January 2013

  • Guan, Ying; Zhang, Yongjun
  • Chemical Society Reviews, Vol. 42, Issue 20
  • DOI: 10.1039/c3cs60152h

Supramolecular Assemblies of 1,4-Benzene Diboronic Acid on KCl(001)
journal, May 2010

  • Pawlak, Rémy; Nony, Laurent; Bocquet, Franck
  • The Journal of Physical Chemistry C, Vol. 114, Issue 20
  • DOI: 10.1021/jp102044u

Nanopatterning of a covalent organic framework host–guest system
journal, January 2016

  • Plas, Jan; Ivasenko, Oleksandr; Martsinovich, Natalia
  • Chemical Communications, Vol. 52, Issue 1
  • DOI: 10.1039/C5CC07557B

Diffusion NMR Spectroscopy in Supramolecular and Combinatorial Chemistry: An Old Parameter?New Insights
journal, January 2005

  • Cohen, Yoram; Avram, Liat; Frish, Limor
  • Angewandte Chemie International Edition, Vol. 44, Issue 4
  • DOI: 10.1002/anie.200300637

Using Diffusion NMR To Characterize Guanosine Self-Association: Insights into Structure and Mechanism
journal, January 2005

  • Kaucher, Mark S.; Lam, Yui-Fai; Pieraccini, Silvia
  • Chemistry - A European Journal, Vol. 11, Issue 1
  • DOI: 10.1002/chem.200400782

Functional G-Quartet Macroscopic Membrane Films
journal, November 2007

  • Arnal-Hérault, Carole; Pasc, Andreea; Michau, Mathieu
  • Angewandte Chemie International Edition, Vol. 46, Issue 44
  • DOI: 10.1002/anie.200702605

Amplification and Transcription of the Dynamic Supramolecular Chirality of the Guanine Quadruplex
journal, June 2007

  • Arnal-Hérault, Carole; Banu, Andreea; Barboiu, Mihail
  • Angewandte Chemie International Edition, Vol. 46, Issue 23
  • DOI: 10.1002/anie.200700787

A non-empirical chromophoric interpretation of CD spectra of DNA G-quadruplex structures
journal, January 2010

  • Masiero, Stefano; Trotta, Roberta; Pieraccini, Silvia
  • Organic & Biomolecular Chemistry, Vol. 8, Issue 12
  • DOI: 10.1039/c003428b

Self-healing metal-coordinated hydrogels using nucleotide ligands
journal, January 2015

  • Liang, Hao; Zhang, Zijie; Yuan, Qipeng
  • Chemical Communications, Vol. 51, Issue 82
  • DOI: 10.1039/C5CC06824J

In Vitro Culture of Human Dermal Fibroblasts on Electrospun Polycaprolactone Collagen Nanofibrous Membrane
journal, June 2006


MTT assay for cell viability: Intracellular localization of the formazan product is in lipid droplets
journal, December 2012