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Title: A narrow open tubular column for high efficiency liquid chromatographic separation

Journal Article · · Analyst
DOI:https://doi.org/10.1039/c7an02065a· OSTI ID:1539862
 [1];  [1];  [2];  [1];  [1];  [1];  [1];  [1]; ORCiD logo [1]
  1. Department of Chemistry and Biochemistry; University of Oklahoma; Norman; USA
  2. Department of Microbiology and Plant Biology; University of Oklahoma; Norman; USA
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We report a great feature of open tubular liquid chromatography when it is run using an extremely narrow (e.g., 2 μm inner diameter) open tubular column: more than 10 million plates per meter can be achieved in less than 10 min and under an elution pressure ofca.20 bar.

Research Organization:
LIU, SHAORONG
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
SC0006351
OSTI ID:
1539862
Journal Information:
Analyst, Vol. 143, Issue 9; ISSN 0003-2654
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English

References (12)

Kinetic optimization of straight open-tubular liquid chromatography journal December 1979
Theoretical Aspects of LC with Packed and Open Small-Bore Columns journal September 1980
Conventional packed columns vs. packed or open tubular microcolumns in liquid chromatography journal August 1981
Liquid chromatography in open-tubular columns journal January 1983
Electrochromatography in chemically modified etched fused-silica capillaries journal June 1996
Microcolumn separations and the analysis of single cells journal October 1989
Separation by flow (hydrodynamic chromatography) of macromolecules performed in open microcapillary tubes journal January 1983
Ultratrace LC/MS Proteomic Analysis Using 10-μm-i.d. Porous Layer Open Tubular Poly(styrene−divinylbenzene) Capillary Columns journal February 2007
Separation of intact proteins on porous layer open tubular (PLOT) columns journal April 2010
Confocal laser-induced fluorescence detector for narrow capillary system with yoctomole limit of detection journal April 2017
Slip Flow in Colloidal Crystals for Ultraefficient Chromatography journal June 2012
Submicrometer Particles and Slip Flow in Liquid Chromatography journal February 2015

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Related Subjects

Chemistry