skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate

Abstract

Not provided.

Authors:
; ; ; ORCiD logo; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Princeton Univ., NJ (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1539779
DOE Contract Number:  
SC0012461
Resource Type:
Journal Article
Journal Name:
Nature Chemical Biology
Additional Journal Information:
Journal Volume: 13; Journal Issue: 10; Journal ID: ISSN 1552-4450
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
Biochemistry & Molecular Biology

Citation Formats

Oslund, Rob C., Su, Xiaoyang, Haugbro, Michael, Kee, Jung-Min, Esposito, Mark, David, Yael, Wang, Boyuan, Ge, Eva, Perlman, David H., Kang, Yibin, Muir, Tom W., and Rabinowitz, Joshua D. Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. United States: N. p., 2017. Web. doi:10.1038/nchembio.2453.
Oslund, Rob C., Su, Xiaoyang, Haugbro, Michael, Kee, Jung-Min, Esposito, Mark, David, Yael, Wang, Boyuan, Ge, Eva, Perlman, David H., Kang, Yibin, Muir, Tom W., & Rabinowitz, Joshua D. Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. United States. doi:10.1038/nchembio.2453.
Oslund, Rob C., Su, Xiaoyang, Haugbro, Michael, Kee, Jung-Min, Esposito, Mark, David, Yael, Wang, Boyuan, Ge, Eva, Perlman, David H., Kang, Yibin, Muir, Tom W., and Rabinowitz, Joshua D. Mon . "Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate". United States. doi:10.1038/nchembio.2453.
@article{osti_1539779,
title = {Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate},
author = {Oslund, Rob C. and Su, Xiaoyang and Haugbro, Michael and Kee, Jung-Min and Esposito, Mark and David, Yael and Wang, Boyuan and Ge, Eva and Perlman, David H. and Kang, Yibin and Muir, Tom W. and Rabinowitz, Joshua D.},
abstractNote = {Not provided.},
doi = {10.1038/nchembio.2453},
journal = {Nature Chemical Biology},
issn = {1552-4450},
number = 10,
volume = 13,
place = {United States},
year = {2017},
month = {8}
}

Works referenced in this record:

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
journal, May 2009


Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth
journal, November 2012


Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
journal, August 2011

  • Possemato, Richard; Marks, Kevin M.; Shaul, Yoav D.
  • Nature, Vol. 476, Issue 7360
  • DOI: 10.1038/nature10350

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells
journal, May 2014

  • Labuschagne, Christiaan F.; van den Broek, Niels J. F.; Mackay, Gillian M.
  • Cell Reports, Vol. 7, Issue 4
  • DOI: 10.1016/j.celrep.2014.04.045

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation
journal, April 2015

  • Mattaini, Katherine R.; Brignole, Edward J.; Kini, Mitali
  • Cancer & Metabolism, Vol. 3, Issue 1
  • DOI: 10.1186/s40170-015-0131-7

PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis
journal, June 2016


Induction of 2,3-bisphosphoglycerate synthase in friend leukemia cells
journal, November 1981

  • Narita, Hiroshi; Yanagawa, Shin-ichi; Sasaki, Ryuzo
  • Biochemical and Biophysical Research Communications, Vol. 103, Issue 1
  • DOI: 10.1016/0006-291X(81)91664-8

2,3-bisphosphoglycerate in erythroid cells
journal, April 1982


Mutase versus synthase: the phosphoglycerate mutase family studied by protein engineering
journal, April 1990

  • White, Malcolm F.; Fothergill-Gilmore, Linda A.
  • Biochemical Society Transactions, Vol. 18, Issue 2
  • DOI: 10.1042/bst0180257

Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation
journal, April 2013

  • Hitosugi, Taro; Zhou, Lu; Fan, Jun
  • Nature Communications, Vol. 4, Issue 1
  • DOI: 10.1038/ncomms2759

Development of Stable Phosphohistidine Analogues
journal, October 2010

  • Kee, Jung-Min; Villani, Bryeanna; Carpenter, Laura R.
  • Journal of the American Chemical Society, Vol. 132, Issue 41
  • DOI: 10.1021/ja104393t

A pan-specific antibody for direct detection of protein histidine phosphorylation
journal, May 2013

  • Kee, Jung-Min; Oslund, Rob C.; Perlman, David H.
  • Nature Chemical Biology, Vol. 9, Issue 7
  • DOI: 10.1038/nchembio.1259

A Phosphohistidine Proteomics Strategy Based on Elucidation of a Unique Gas-Phase Phosphopeptide Fragmentation Mechanism
journal, September 2014

  • Oslund, Rob C.; Kee, Jung-Min; Couvillon, Anthony D.
  • Journal of the American Chemical Society, Vol. 136, Issue 37
  • DOI: 10.1021/ja507614f

A Second-Generation Phosphohistidine Analog for Production of Phosphohistidine Antibodies
journal, December 2014

  • Kee, Jung-Min; Oslund, Rob C.; Couvillon, Anthony D.
  • Organic Letters, Vol. 17, Issue 2
  • DOI: 10.1021/ol503320p

Novel Placental Expression of 2,3-Bisphosphoglycerate Mutase
journal, August 2006


Genome engineering using the CRISPR-Cas9 system
journal, October 2013


Denaturation and renaturation of the monomeric phosphoglycerate mutase from Schizosaccharomyces pombe
journal, July 1987

  • Johnson, C. M.; Price, N. C.
  • Biochemical Journal, Vol. 245, Issue 2
  • DOI: 10.1042/bj2450525

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells
journal, September 2010


Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite
journal, August 2013


Seeing the Process of Histidine Phosphorylation in Human Bisphosphoglycerate Mutase
journal, October 2006

  • Wang, Yanli; Liu, Lin; Wei, Zhiyi
  • Journal of Biological Chemistry, Vol. 281, Issue 51
  • DOI: 10.1074/jbc.M606421200

Monoclonal 1- and 3-Phosphohistidine Antibodies: New Tools to Study Histidine Phosphorylation
journal, July 2015


A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites
journal, January 2006

  • Lu, Wenyun; Kimball, Elizabeth; Rabinowitz, Joshua D.
  • Journal of the American Society for Mass Spectrometry, Vol. 17, Issue 1, p. 37-50
  • DOI: 10.1016/j.jasms.2005.09.001

Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox
journal, November 2016


Metabolomic Analysis and Visualization Engine for LC−MS Data
journal, December 2010

  • Melamud, Eugene; Vastag, Livia; Rabinowitz, Joshua D.
  • Analytical Chemistry, Vol. 82, Issue 23
  • DOI: 10.1021/ac1021166

In-gel digestion for mass spectrometric characterization of proteins and proteomes
journal, December 2006


Stop and Go Extraction Tips for Matrix-Assisted Laser Desorption/Ionization, Nanoelectrospray, and LC/MS Sample Pretreatment in Proteomics
journal, February 2003

  • Rappsilber, Juri; Ishihama, Yasushi; Mann, Matthias
  • Analytical Chemistry, Vol. 75, Issue 3
  • DOI: 10.1021/ac026117i

Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins
journal, April 2015

  • David, Yael; Vila-Perelló, Miquel; Verma, Shivam
  • Nature Chemistry, Vol. 7, Issue 5
  • DOI: 10.1038/nchem.2224

Easy quantitative assessment of genome editing by sequence trace decomposition
journal, October 2014

  • Brinkman, Eva K.; Chen, Tao; Amendola, Mario
  • Nucleic Acids Research, Vol. 42, Issue 22
  • DOI: 10.1093/nar/gku936

Improved vectors and genome-wide libraries for CRISPR screening
journal, July 2014

  • Sanjana, Neville E.; Shalem, Ophir; Zhang, Feng
  • Nature Methods, Vol. 11, Issue 8
  • DOI: 10.1038/nmeth.3047

Metabolite concentrations, fluxes and free energies imply efficient enzyme usage
journal, May 2016

  • Park, Junyoung O.; Rubin, Sara A.; Xu, Yi-Fan
  • Nature Chemical Biology, Vol. 12, Issue 7
  • DOI: 10.1038/nchembio.2077