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Title: Industrial biomanufacturing: The future of chemical production

Abstract

The current model for industrial chemical manufacturing employs large-scale megafacilities that benefit from economies of unit scale. However, this strategy faces environmental, geographical, political, and economic challenges associated with energy and manufacturing demands. We review how exploiting biological processes for manufacturing (i.e., industrial biomanufacturing) addresses these concerns while also supporting and benefiting from economies of unit number. Key to this approach is the inherent small scale and capital efficiency of bioprocesses and the ability of engineered biocatalysts to produce designer products at high carbon and energy efficiency with adjustable output, at high selectivity, and under mild process conditions. The biological conversion of single-carbon compounds represents a test bed to establish this paradigm, enabling rapid, mobile, and widespread deployment, access to remote and distributed resources, and adaptation to new and changing markets.

Authors:
; ;
Publication Date:
Research Org.:
Rice Univ., Houston, TX (United States)
Sponsoring Org.:
USDOE Advanced Research Projects Agency - Energy (ARPA-E)
OSTI Identifier:
1536837
DOE Contract Number:  
AR0000762
Resource Type:
Journal Article
Journal Name:
Science
Additional Journal Information:
Journal Volume: 355; Journal Issue: 6320; Journal ID: ISSN 0036-8075
Publisher:
AAAS
Country of Publication:
United States
Language:
English
Subject:
Science & Technology - Other Topics

Citation Formats

Clomburg, James M., Crumbley, Anna M., and Gonzalez, Ramon. Industrial biomanufacturing: The future of chemical production. United States: N. p., 2017. Web. doi:10.1126/science.aag0804.
Clomburg, James M., Crumbley, Anna M., & Gonzalez, Ramon. Industrial biomanufacturing: The future of chemical production. United States. doi:10.1126/science.aag0804.
Clomburg, James M., Crumbley, Anna M., and Gonzalez, Ramon. Thu . "Industrial biomanufacturing: The future of chemical production". United States. doi:10.1126/science.aag0804.
@article{osti_1536837,
title = {Industrial biomanufacturing: The future of chemical production},
author = {Clomburg, James M. and Crumbley, Anna M. and Gonzalez, Ramon},
abstractNote = {The current model for industrial chemical manufacturing employs large-scale megafacilities that benefit from economies of unit scale. However, this strategy faces environmental, geographical, political, and economic challenges associated with energy and manufacturing demands. We review how exploiting biological processes for manufacturing (i.e., industrial biomanufacturing) addresses these concerns while also supporting and benefiting from economies of unit number. Key to this approach is the inherent small scale and capital efficiency of bioprocesses and the ability of engineered biocatalysts to produce designer products at high carbon and energy efficiency with adjustable output, at high selectivity, and under mild process conditions. The biological conversion of single-carbon compounds represents a test bed to establish this paradigm, enabling rapid, mobile, and widespread deployment, access to remote and distributed resources, and adaptation to new and changing markets.},
doi = {10.1126/science.aag0804},
journal = {Science},
issn = {0036-8075},
number = 6320,
volume = 355,
place = {United States},
year = {2017},
month = {1}
}

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