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Title: Enhanced sensitivity and metabolite coverage with remote laser ablation electrospray ionization-mass spectrometry aided by coaxial plume and gas dynamics

Journal Article · · Analyst
DOI:https://doi.org/10.1039/c7an00805h· OSTI ID:1535173

Conical ablation chamber for remote LAESI-MS exhibits enhanced molecular coverage compared to conventional arrangement.

Research Organization:
George Washington Univ., Washington, DC (United States); Univ. of Missouri, Columbia, MO (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
FG02-01ER15129; SC0013978
OSTI ID:
1535173
Journal Information:
Analyst, Vol. 142, Issue 17; ISSN 0003-2654
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English

References (38)

Direct, trace level detection of explosives on ambient surfaces by desorption electrospray ionization mass spectrometry journal January 2005
Desorption Electrospray Ionization Mass Spectrometry for High-Throughput Analysis of Pharmaceutical Samples in the Ambient Environment journal November 2005
Forensic applications of ambient ionization mass spectrometry journal February 2009
Ambient Molecular Imaging and Depth Profiling of Live Tissue by Infrared Laser Ablation Electrospray Ionization Mass Spectrometry journal June 2008
Ambient mass spectrometry for in vivo local analysis and in situ molecular tissue imaging journal April 2012
Ambient desorption ionization mass spectrometry journal April 2008
Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization journal October 2004
Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions journal April 2005
Laser Ablation Electrospray Ionization for Atmospheric Pressure, in Vivo, and Imaging Mass Spectrometry journal November 2007
In vivo Real-Time Mass Spectrometry for Guided Surgery Application journal May 2016
Rapid Evaporative Ionization Mass Spectrometry Imaging Platform for Direct Mapping from Bulk Tissue and Bacterial Growth Media journal February 2015
Intraoperative Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry journal July 2013
Study of the efficiency for ion transfer through bent capillaries: Ion transfer through bent capillaries journal October 2012
Non-Proximate Detection of Small and Large Molecules by Desorption Electrospray Ionization and Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry:  Instrumentation and Applications in Forensics, Chemistry, and Biology journal September 2007
Gas-flow assisted ion transfer for mass spectrometry: Flow assisted ion transfer journal February 2012
Real-Time Sample Analysis Using a Sampling Probe and Miniature Mass Spectrometer journal August 2015
Aerodynamic focusing of particles in a carrier gas journal October 1988
Remote mass spectrometric sampling of electrospray- and desorption electrospray-generated ions using an air ejector journal October 2007
The influence of ablation carrier gasses Ar, He and Ne on the particle size distribution and transport efficiencies of laser ablation-induced aerosols: implications for LA–ICP–MS journal February 2003
Analyte response in laser ablation inductively coupled plasma mass spectrometry journal May 2006
Theoretical description and experimental observation of aerosol transport processes in laser ablation inductively coupled plasma mass spectrometry journal January 2001
Effects of Particle Size Distribution on Inductively Coupled Plasma Mass Spectrometry Signal Intensity during Laser Ablation of Glass Samples journal November 1999
Characterization and Application of a Hybrid Optical Microscopy/Laser Ablation Liquid Vortex Capture/Electrospray Ionization System for Mass Spectrometry Imaging with Sub-micrometer Spatial Resolution journal July 2015
Laser microdissection and atmospheric pressure chemical ionization mass spectrometry coupled for multimodal imaging: LA-APCI/MS imaging journal May 2013
Infrared laser ablation sample transfer for on-line liquid chromatography electrospray ionization mass spectrometry: IR LA sample transfer for on-line LC ESI MS journal September 2012
Ambient laser ablation sampling for capillary electrophoresis mass spectrometry: Ambient laser ablation sampling for CE/MS journal June 2013
Remote laser ablation electrospray ionization mass spectrometry for non-proximate analysis of biological tissues: Non-proximate analysis of biological tissues by LAESI-MS journal December 2014
Plasticizers, antioxidants, and other contaminants found in air delivered by PVC tubing used in respiratory therapy journal January 2003
In Situ Analysis of Small Populations of Adherent Mammalian Cells Using Laser Ablation Electrospray Ionization Mass Spectrometry in Transmission Geometry journal November 2015
Drag Coefficients of Spheres in Continuum and Rarefied Flows journal June 1976
Material ejection in nanosecond Er:YAG laser ablation of water, liver, and skin journal July 2005
Internal energy deposition and ion fragmentation in atmospheric-pressure mid-infrared laser ablation electrospray ionization journal January 2012
Particle size measurement from infrared laser ablation of tissue journal January 2016
Quantification of plant surface metabolites by matrix-assisted laser desorption-ionization mass spectrometry imaging: glucosinolates on Arabidopsis thaliana leaves journal March 2015
Glucosinolates in Brassica vegetables: The influence of the food supply chain on intake, bioavailability and human health journal November 2008
The chemical diversity and distribution of glucosinolates and isothiocyanates among plants journal January 2001
mMass 3: A Cross-Platform Software Environment for Precise Analysis of Mass Spectrometric Data journal June 2010
Analysis of glucosinolates, isothiocyanates, and amine degradation products in vegetable extracts and blood plasma by LC–MS/MS journal December 2005