Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens
Abstract
Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm), the etiologic agents of melioidosis and glanders, respectively, cause severe disease in both humans and animals. Studies have highlighted the importance of Bp and Bm lipopolysaccharides (LPS) as vaccine candidates. Here we describe the synthesis of seven oligosaccharides as the minimal structures featuring all of the reported acetylation/methylation patterns associated with Bp and Bm LPS O-antigens (OAgs). Our approach is based on the conversion of an L-rhamnose into a 6-deoxy-L-talose residue at a late stage of the synthetic sequence. Using biochemical and biophysical methods, we demonstrate the binding of several Bp and Bm LPS-specific monoclonal antibodies with terminal OAg residues. Mice immunized with terminal disaccharide–CRM197 constructs produced high-titer antibody responses that crossreacted with Bm-like OAgs. Collectively, these studies serve as foundation for the development of novel therapeutics, diagnostics, and vaccine candidates to combat diseases caused by Bp and Bm.
- Authors:
-
- Université de Poitiers (France)
- Université de Poitiers (France); Wroclaw Univ. of Environmental and Life Sciences (Poland)
- Univ. of Nevada School of Medicine, Reno, NV (United States); Prince of Songkla Univ., Songkhla (Thailand)
- Univ. of South Alabama, Mobile, AL (United States)
- Univ. Paris-Saclay, Versailles (France)
- Università di Napoli Federico II, Complesso Universitario Monte S. Angelo, Naples (Italy)
- Mahidol Univ., Bangkok (Thailand)
- Univ. of Nevada School of Medicine, Reno, NV (United States)
- Université de Poitiers (France); Univ. of Quebec, Laval QC (Canada)
- Publication Date:
- Research Org.:
- Univ. of Georgia, Athens, GA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1535102
- Grant/Contract Number:
- FG02-93ER20097
- Resource Type:
- Journal Article: Accepted Manuscript
- Journal Name:
- Nature Communications
- Additional Journal Information:
- Journal Volume: 8; Journal Issue: 1; Journal ID: ISSN 2041-1723
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Tamigney Kenfack, Marielle, Mazur, Marcelina, Nualnoi, Teerapat, Shaffer, Teresa L., Ngassimou, Abba, Blériot, Yves, Marrot, Jérôme, Marchetti, Roberta, Sintiprungrat, Kitisak, Chantratita, Narisara, Silipo, Alba, Molinaro, Antonio, AuCoin, David P., Burtnick, Mary N., Brett, Paul J., and Gauthier, Charles. Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens. United States: N. p., 2017.
Web. doi:10.1038/s41467-017-00173-8.
Tamigney Kenfack, Marielle, Mazur, Marcelina, Nualnoi, Teerapat, Shaffer, Teresa L., Ngassimou, Abba, Blériot, Yves, Marrot, Jérôme, Marchetti, Roberta, Sintiprungrat, Kitisak, Chantratita, Narisara, Silipo, Alba, Molinaro, Antonio, AuCoin, David P., Burtnick, Mary N., Brett, Paul J., & Gauthier, Charles. Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens. United States. https://doi.org/10.1038/s41467-017-00173-8
Tamigney Kenfack, Marielle, Mazur, Marcelina, Nualnoi, Teerapat, Shaffer, Teresa L., Ngassimou, Abba, Blériot, Yves, Marrot, Jérôme, Marchetti, Roberta, Sintiprungrat, Kitisak, Chantratita, Narisara, Silipo, Alba, Molinaro, Antonio, AuCoin, David P., Burtnick, Mary N., Brett, Paul J., and Gauthier, Charles. 2017.
"Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens". United States. https://doi.org/10.1038/s41467-017-00173-8. https://www.osti.gov/servlets/purl/1535102.
@article{osti_1535102,
title = {Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens},
author = {Tamigney Kenfack, Marielle and Mazur, Marcelina and Nualnoi, Teerapat and Shaffer, Teresa L. and Ngassimou, Abba and Blériot, Yves and Marrot, Jérôme and Marchetti, Roberta and Sintiprungrat, Kitisak and Chantratita, Narisara and Silipo, Alba and Molinaro, Antonio and AuCoin, David P. and Burtnick, Mary N. and Brett, Paul J. and Gauthier, Charles},
abstractNote = {Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm), the etiologic agents of melioidosis and glanders, respectively, cause severe disease in both humans and animals. Studies have highlighted the importance of Bp and Bm lipopolysaccharides (LPS) as vaccine candidates. Here we describe the synthesis of seven oligosaccharides as the minimal structures featuring all of the reported acetylation/methylation patterns associated with Bp and Bm LPS O-antigens (OAgs). Our approach is based on the conversion of an L-rhamnose into a 6-deoxy-L-talose residue at a late stage of the synthetic sequence. Using biochemical and biophysical methods, we demonstrate the binding of several Bp and Bm LPS-specific monoclonal antibodies with terminal OAg residues. Mice immunized with terminal disaccharide–CRM197 constructs produced high-titer antibody responses that crossreacted with Bm-like OAgs. Collectively, these studies serve as foundation for the development of novel therapeutics, diagnostics, and vaccine candidates to combat diseases caused by Bp and Bm.},
doi = {10.1038/s41467-017-00173-8},
url = {https://www.osti.gov/biblio/1535102},
journal = {Nature Communications},
issn = {2041-1723},
number = 1,
volume = 8,
place = {United States},
year = {Mon Jul 24 00:00:00 EDT 2017},
month = {Mon Jul 24 00:00:00 EDT 2017}
}
Web of Science
Works referenced in this record:
Detailed structural analysis of the O-polysaccharide expressed by Burkholderia thailandensis E264
journal, December 2012
- Heiss, Christian; Burtnick, Mary N.; Black, Ian
- Carbohydrate Research, Vol. 363
Identification of Circulating Bacterial Antigens by
In Vivo
Microbial Antigen Discovery
journal, September 2011
- Nuti, Dana E.; Crump, Reva B.; Dwi Handayani, Farida
- mBio, Vol. 2, Issue 4
Fate of a Burkholderia pseudomallei Lipopolysaccharide Mutant in the Mouse Macrophage Cell Line RAW 264.7: Possible Role for the O-Antigenic Polysaccharide Moiety of Lipopolysaccharide in Internalization and Intracellular Survival
journal, June 2007
- Arjcharoen, S.; Wikraiphat, C.; Pudla, M.
- Infection and Immunity, Vol. 75, Issue 9
Iodonium promoted reactions of disarmed thioglycosides
journal, January 1990
- Konradsson, Peter; Udodong, Uko E.; Fraser-Reid, Bert
- Tetrahedron Letters, Vol. 31, Issue 30
Molecular and Physical Characterization of Burkholderia mallei O Antigens
journal, February 2002
- Burtnick, M. N.; Brett, P. J.; Woods, D. E.
- Journal of Bacteriology, Vol. 184, Issue 3
Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis
journal, December 2004
- Nelson, M.
- Journal of Medical Microbiology, Vol. 53, Issue 12
Development of Rapid Enzyme-Linked Immunosorbent Assays for Detection of Antibodies to Burkholderia pseudomallei
journal, February 2016
- Suttisunhakul, Vichaya; Wuthiekanun, Vanaporn; Brett, Paul J.
- Journal of Clinical Microbiology, Vol. 54, Issue 5
Synthesis of All Eight Stereoisomeric 6-Deoxy- L -hexopyranosyl Donors - Trends in Using Stereoselective Reductions or Mitsunobu Epimerizations : Synthesis of 6-Deoxy-
journal, October 2014
- Frihed, Tobias Gylling; Pedersen, Christian Marcus; Bols, Mikael
- European Journal of Organic Chemistry, Vol. 2014, Issue 35
mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemia
journal, March 2004
- Kozel, T. R.; Murphy, W. J.; Brandt, S.
- Proceedings of the National Academy of Sciences, Vol. 101, Issue 14
Elaboration of Monoarabinofuranosidic Building Blocks
journal, November 2002
- Sanchez, Sylvie; Bamhaoud, Toufiq; Prandi, Jacques
- European Journal of Organic Chemistry, Vol. 2002, Issue 22
Activation of Toll-like receptors by Burkholderia pseudomallei
journal, January 2008
- West, T. Eoin; Ernst, Robert K.; Jansson-Hutson, Malinka J.
- BMC Immunology, Vol. 9, Issue 1
Efficient synthesis of a 6-deoxytalose tetrasaccharide related to the antigenic O-polysaccharide produced by Aggregatibacter actinomycetemcomitans serotype c
journal, June 2010
- Cai, Xiangyan; Zong, Guanghui; Xu, Yanjun
- Carbohydrate Research, Vol. 345, Issue 9
Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei
journal, April 2006
- Wiersinga, W. Joost; van der Poll, Tom; White, Nicholas J.
- Nature Reviews Microbiology, Vol. 4, Issue 4
Structural and Biological Diversity of Lipopolysaccharides from Burkholderia pseudomallei and Burkholderia thailandensis
journal, August 2009
- Novem, V.; Shui, G.; Wang, D.
- Clinical and Vaccine Immunology, Vol. 16, Issue 10
Regioselective Activation of Glycosyl Acceptors by a Diarylborinic Acid-Derived Catalyst
journal, September 2011
- Gouliaras, Christina; Lee, Doris; Chan, Lina
- Journal of the American Chemical Society, Vol. 133, Issue 35
Polysaccharide Specific Monoclonal Antibodies Provide Passive Protection against Intranasal Challenge with Burkholderia pseudomallei
journal, April 2012
- AuCoin, David P.; Reed, Dana E.; Marlenee, Nicole L.
- PLoS ONE, Vol. 7, Issue 4
Identification of 3,6-di-O-acetyl-1,2,4-O-orthoacetyl-α-d-glucopyranose as a direct evidence for the 4-O-acyl group participation in glycosylation
journal, January 2011
- Ma, Yuyong; Lian, Gaoyan; Li, Yao
- Chemical Communications, Vol. 47, Issue 26
In Vitro and In Vivo Studies of Monoclonal Antibodies with Prominent Bactericidal Activity against Burkholderia pseudomallei and Burkholderia mallei
journal, March 2011
- Zhang, Shimin; Feng, Shaw-Huey; Li, Bingjie
- Clinical and Vaccine Immunology, Vol. 18, Issue 5
Burkholderia pseudomallei Capsular Polysaccharide Conjugates Provide Protection against Acute Melioidosis
journal, May 2014
- Scott, Andrew E.; Burtnick, Mary N.; Stokes, Margaret G. M.
- Infection and Immunity, Vol. 82, Issue 8
The type II O-antigenic polysaccharide moiety of Burkholderia pseudomallei lipopolysaccharide is required for serum resistance and virulence
journal, December 1998
- DeShazer, David; Brett, Paul J.; Woods, Donald E.
- Molecular Microbiology, Vol. 30, Issue 5
Revised structures for the predominant O-polysaccharides expressed by Burkholderia pseudomallei and Burkholderia mallei
journal, November 2013
- Heiss, Christian; Burtnick, Mary N.; Roberts, Rosemary A.
- Carbohydrate Research, Vol. 381
Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity
journal, January 2014
- Gauthier, Charles; Chassagne, Pierre; Theillet, François-Xavier
- Org. Biomol. Chem., Vol. 12, Issue 24
The wbiA locus is required for the 2- O -acetylation of lipopolysaccharides expressed by Burkholderia pseudomallei and Burkholderia thailandensis
journal, January 2003
- Brett, Paul J.; Burtnick, Mary N.; Woods, Donald E.
- FEMS Microbiology Letters, Vol. 218, Issue 2
Halide ion catalyzed glycosidation reactions. Syntheses of .alpha.-linked disaccharides
journal, July 1975
- Lemieux, R. U.; Hendriks, K. B.; Stick, R. V.
- Journal of the American Chemical Society, Vol. 97, Issue 14
Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates.
journal, January 1996
- Brett, P. J.; Woods, D. E.
- Infection and immunity, Vol. 64, Issue 7
A gold nanoparticle-linked glycoconjugate vaccine against Burkholderia mallei
journal, February 2015
- Gregory, Anthony E.; Judy, Barbara M.; Qazi, Omar
- Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 11, Issue 2
Progress toward development of vaccines against melioidosis: A review
journal, August 2010
- Sarkar-Tyson, Mitali; Titball, Richard W.
- Clinical Therapeutics, Vol. 32, Issue 8
Exploiting Molecular Virulence Determinants in Burkholderia to Develop Vaccine Antigens
journal, April 2015
- Casey, William; McClean, Siobhan
- Current Medicinal Chemistry, Vol. 22, Issue 14
Passive protection against Burkholderia pseudomallei infection in mice by monoclonal antibodies against capsular polysaccharide, lipopolysaccharide or proteins
journal, December 2002
- Russell, P.; Griffin, K. F.; Jones, S. M.
- Journal of Medical Microbiology, Vol. 51, Issue 12
Comparative in vivo and in vitro analyses of putative virulence factors of Burkholderia pseudomallei using lipopolysaccharide, capsule and flagellin mutants
journal, August 2009
- Wikraiphat, Chanthiwa; Charoensap, Jaruek; Utaisincharoen, Pongsak
- FEMS Immunology & Medical Microbiology, Vol. 56, Issue 3
Glanders in Animals: A Review on Epidemiology, Clinical Presentation, Diagnosis and Countermeasures: Glanders in Solipeds
journal, May 2012
- Khan, I.; Wieler, L. H.; Melzer, F.
- Transboundary and Emerging Diseases, Vol. 60, Issue 3
Antilipopolysaccharide II: An Antibody Protective Against Fatal Melioidosis
journal, October 1999
- Charuchaimontri, Chadarat; Suputtamongkol, Yupin; Nilakul, Churairat
- Clinical Infectious Diseases, Vol. 29, Issue 4
Production of a recombinant vaccine candidate against Burkholderia pseudomallei exploiting the bacterial N-glycosylation machinery
journal, July 2014
- Garcia-Quintanilla, Fatima; Iwashkiw, Jeremy A.; Price, Nancy L.
- Frontiers in Microbiology, Vol. 5
Survey of Innate Immune Responses to Burkholderia pseudomallei in Human Blood Identifies a Central Role for Lipopolysaccharide
journal, November 2013
- Chantratita, Narisara; Tandhavanant, Sarunporn; Myers, Nicolle D.
- PLoS ONE, Vol. 8, Issue 11
Production of a recombinant vaccine candidate against Burkholderia pseudomallei exploiting the bacterial N-glycosylation machinery
journal, July 2014
- Garcia-Quintanilla, Fatima; Iwashkiw, Jeremy A.; Price, Nancy L.
- Frontiers in Microbiology, Vol. 5
Burkholderia mallei expresses a unique lipopolysaccharide mixture that is a potent activator of human Toll-like receptor 4 complexes : Biological activity of
journal, November 2006
- Brett, Paul J.; Burtnick, Mary N.; Snyder, D. Scott
- Molecular Microbiology, Vol. 63, Issue 2
Structure of the polysaccharide chains of Pseudomonas pseudomallei lipopolysaccharides
journal, September 1992
- Knirel, Yuriy A.; Paramonov, Nikolay A.; Shashkov, Alexander S.
- Carbohydrate Research, Vol. 233
An efficient approach to O-glycosides through CuBr2-Bu4NBr mediated activation of glycosides
journal, November 1986
- Sato, Susumu; Mori, Masato; Ito, Yukishige
- Carbohydrate Research, Vol. 155
Regioselective Activation of Glycosyl Acceptors by a Diarylborinic Acid-Derived Catalyst
journal, September 2011
- Gouliaras, Christina; Lee, Doris; Chan, Lina
- Journal of the American Chemical Society, Vol. 133, Issue 35
Identification of 3,6-di-O-acetyl-1,2,4-O-orthoacetyl-α-d-glucopyranose as a direct evidence for the 4-O-acyl group participation in glycosylation
journal, January 2011
- Ma, Yuyong; Lian, Gaoyan; Li, Yao
- Chemical Communications, Vol. 47, Issue 26
A gold nanoparticle-linked glycoconjugate vaccine against Burkholderia mallei
journal, February 2015
- Gregory, Anthony E.; Judy, Barbara M.; Qazi, Omar
- Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 11, Issue 2
Burkholderia pseudomallei Capsular Polysaccharide Recognition by a Monoclonal Antibody Reveals Key Details toward a Biodefense Vaccine and Diagnostics against Melioidosis
journal, July 2015
- Marchetti, Roberta; Dillon, Michael J.; Burtnick, Mary N.
- ACS Chemical Biology, Vol. 10, Issue 10
Melioidosis: Evolving Concepts in Epidemiology, Pathogenesis, and Treatment
journal, February 2015
- Currie, Bart
- Seminars in Respiratory and Critical Care Medicine, Vol. 36, Issue 01
Development of Burkholderia mallei and pseudomallei vaccines
journal, January 2013
- Silva, Ediane B.; Dow, Steven W.
- Frontiers in Cellular and Infection Microbiology, Vol. 3
Strategies toward vaccines against Burkholderia mallei and Burkholderia pseudomallei
journal, November 2008
- Bondi, Sara K.; Goldberg, Joanna B.
- Expert Review of Vaccines, Vol. 7, Issue 9
Synthesis of Disaccharides Containing 6-Deoxy-a-L-talose as Potential Heparan Sulfate Mimetics
journal, August 2012
- Fairweather, Jon K.; Liu, Ligong; Karoli, Tomislav
- Molecules, Vol. 17, Issue 8
Passive Protection of Diabetic Rats with Antisera Specific for the Polysaccharide Portion of the Lipopolysaccharide Isolated from Pseudomonas pseudomallei
journal, January 1994
- Bryan, Larry E.; Wong, Sallene; Woods, Don E.
- Canadian Journal of Infectious Diseases, Vol. 5, Issue 4
mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemia
journal, March 2004
- Kozel, T. R.; Murphy, W. J.; Brandt, S.
- Proceedings of the National Academy of Sciences, Vol. 101, Issue 14
Detailed structural analysis of the O-polysaccharide expressed by Burkholderia thailandensis E264
journal, December 2012
- Heiss, Christian; Burtnick, Mary N.; Black, Ian
- Carbohydrate Research, Vol. 363
Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine
journal, January 2015
- Torres, Alfredo G.; Gregory, Anthony E.; Hatcher, Christopher L.
- Vaccine, Vol. 33, Issue 5
Immunity to Burkholderia pseudomallei
journal, January 2009
- Wiersinga, Willem J.; van der Poll, Tom
- Current Opinion in Infectious Diseases, Vol. 22, Issue 2
1,2,5-ortho esters of d-arabinose as versatile arabinofuranosidic building blocks. Concise synthesis of the tetrasaccharidic cap of the lipoarabinomannan of Mycobacterium tuberculosis
journal, January 2000
- Bamhaoud, Toufiq; Sanchez, Sylvie; Prandi, Jacques
- Chemical Communications, Issue 8
Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis
journal, December 2004
- Nelson, M.
- Journal of Medical Microbiology, Vol. 53, Issue 12
Activation of Toll-like receptors by Burkholderia pseudomallei
journal, January 2008
- West, T. Eoin; Ernst, Robert K.; Jansson-Hutson, Malinka J.
- BMC Immunology, Vol. 9, Issue 1
Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei
journal, April 2006
- Wiersinga, W. Joost; van der Poll, Tom; White, Nicholas J.
- Nature Reviews Microbiology, Vol. 4, Issue 4
Progress toward development of vaccines against melioidosis: A review
journal, August 2010
- Sarkar-Tyson, Mitali; Titball, Richard W.
- Clinical Therapeutics, Vol. 32, Issue 8
Monoclonal Antibodies Passively Protect BALB/c Mice against Burkholderia mallei Aerosol Challenge
journal, February 2006
- Trevino, S. R.; Permenter, A. R.; England, M. J.
- Infection and Immunity, Vol. 74, Issue 3
Melioidosis Vaccines: A Systematic Review and Appraisal of the Potential to Exploit Biodefense Vaccines for Public Health Purposes
journal, January 2012
- Peacock, Sharon J.; Limmathurotsakul, Direk; Lubell, Yoel
- PLoS Neglected Tropical Diseases, Vol. 6, Issue 1
Halide ion catalyzed glycosidation reactions. Syntheses of .alpha.-linked disaccharides
journal, July 1975
- Lemieux, R. U.; Hendriks, K. B.; Stick, R. V.
- Journal of the American Chemical Society, Vol. 97, Issue 14
Temperature dependence of ligand–protein complex formation as reflected by saturation transfer difference NMR experiments
journal, January 2007
- Groves, Patrick; Kövér, Katalin E.; André, Sabine
- Magnetic Resonance in Chemistry, Vol. 45, Issue 9
Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans
journal, April 2016
- Broecker, Felix; Hanske, Jonas; Martin, Christopher E.
- Nature Communications, Vol. 7, Issue 1
The wbiA locus is required for the 2- O -acetylation of lipopolysaccharides expressed by Burkholderia pseudomallei and Burkholderia thailandensis
journal, January 2003
- Brett, Paul J.; Burtnick, Mary N.; Woods, Donald E.
- FEMS Microbiology Letters, Vol. 218, Issue 2
Development of novel O-polysaccharide based glycoconjugates for immunization against glanders
journal, January 2012
- Burtnick, Mary N.; Heiss, Christian; Schuler, A. Michele
- Frontiers in Cellular and Infection Microbiology, Vol. 2
Development of Vaccines Against Burkholderia Pseudomallei
journal, January 2011
- Patel, Natasha; Conejero, Laura; De Reynal, Melanie
- Frontiers in Microbiology, Vol. 2
Polysaccharide Specific Monoclonal Antibodies Provide Passive Protection against Intranasal Challenge with Burkholderia pseudomallei
journal, April 2012
- AuCoin, David P.; Reed, Dana E.; Marlenee, Nicole L.
- PLoS ONE, Vol. 7, Issue 4
“Rules of Engagement” of Protein-Glycoconjugate Interactions: A Molecular View Achievable by using NMR Spectroscopy and Molecular Modeling
journal, June 2016
- Marchetti, Roberta; Perez, Serge; Arda, Ana
- ChemistryOpen, Vol. 5, Issue 4
Revised structures for the predominant O-polysaccharides expressed by Burkholderia pseudomallei and Burkholderia mallei
journal, November 2013
- Heiss, Christian; Burtnick, Mary N.; Roberts, Rosemary A.
- Carbohydrate Research, Vol. 381
Strategies toward vaccines against Burkholderia mallei and Burkholderia pseudomallei
journal, November 2008
- Bondi, Sara K.; Goldberg, Joanna B.
- Expert Review of Vaccines, Vol. 7, Issue 9
Synthesis of Disaccharides Containing 6-Deoxy-a-L-talose as Potential Heparan Sulfate Mimetics
journal, August 2012
- Fairweather, Jon K.; Liu, Ligong; Karoli, Tomislav
- Molecules, Vol. 17, Issue 8
Orthoesters of sugars
journal, June 1971
- Bochkov, A. F.; Obruchnikov, I. V.; Kochetkov, N. K.
- Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, Vol. 20, Issue 6
Efficient synthesis of a 6-deoxytalose tetrasaccharide related to the antigenic O-polysaccharide produced by Aggregatibacter actinomycetemcomitans serotype c
journal, June 2010
- Cai, Xiangyan; Zong, Guanghui; Xu, Yanjun
- Carbohydrate Research, Vol. 345, Issue 9
Regioselective manipulation of hydroxyl groups via organotin derivatives
journal, January 1985
- David, S.; Hanessian, S.
- Tetrahedron, Vol. 41, Issue 4
Synthesis of All Eight Stereoisomeric 6-Deoxy- L -hexopyranosyl Donors - Trends in Using Stereoselective Reductions or Mitsunobu Epimerizations : Synthesis of 6-Deoxy-
journal, October 2014
- Frihed, Tobias Gylling; Pedersen, Christian Marcus; Bols, Mikael
- European Journal of Organic Chemistry, Vol. 2014, Issue 35
Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis
journal, November 2010
- Ngugi, Sarah A.; Ventura, Valeria V.; Qazi, Omar
- Vaccine, Vol. 28, Issue 47
Passive protection against Burkholderia pseudomallei infection in mice by monoclonal antibodies against capsular polysaccharide, lipopolysaccharide or proteins
journal, December 2002
- Russell, P.; Griffin, K. F.; Jones, S. M.
- Journal of Medical Microbiology, Vol. 51, Issue 12
Survey of Innate Immune Responses to Burkholderia pseudomallei in Human Blood Identifies a Central Role for Lipopolysaccharide
journal, November 2013
- Chantratita, Narisara; Tandhavanant, Sarunporn; Myers, Nicolle D.
- PLoS ONE, Vol. 8, Issue 11
Exploiting Molecular Virulence Determinants in Burkholderia to Develop Vaccine Antigens
journal, April 2015
- Casey, William; McClean, Siobhan
- Current Medicinal Chemistry, Vol. 22, Issue 14
Melioidosis: Evolving Concepts in Epidemiology, Pathogenesis, and Treatment
journal, February 2015
- Currie, Bart
- Seminars in Respiratory and Critical Care Medicine, Vol. 36, Issue 01
Rigid conformation of tricyclic orthoesters of sugars
journal, February 1971
- Bochkov, A. F.; Dashunin, V. M.; Kessenikh, A. V.
- Carbohydrate Research, Vol. 16, Issue 2
A novel promoter for the efficient construction of 1,2-trans linkages in glycoside synthesis, using thioglycosides as glycosyl donors
journal, June 1986
- Fügedi, Peter; Garegg, Per J.
- Carbohydrate Research, Vol. 149, Issue 1
Structural characterization of the lipopolysaccharide O antigens of Burkholderia pseudomallei.
journal, January 1995
- Perry, M. B.; MacLean, L. L.; Schollaardt, T.
- Infection and immunity, Vol. 63, Issue 9
Specificity and functional activity of anti-Burkholderia pseudomallei polysaccharide antibodies.
journal, January 1997
- Ho, M.; Schollaardt, T.; Smith, M. D.
- Infection and immunity, Vol. 65, Issue 9
Development of Burkholderia mallei and pseudomallei vaccines
journal, January 2013
- Silva, Ediane B.; Dow, Steven W.
- Frontiers in Cellular and Infection Microbiology, Vol. 3
Colony Morphology Variation of Burkholderia pseudomallei Is Associated with Antigenic Variation and O-Polysaccharide Modification
journal, March 2015
- Wikraiphat, Chanthiwa; Saiprom, Natnaree; Tandhavanant, Sarunporn
- Infection and Immunity, Vol. 83, Issue 5
Present and future therapeutic strategies for melioidosis and glanders
journal, March 2010
- Estes, D. Mark; Dow, Steven W.; Schweizer, Herbert P.
- Expert Review of Anti-infective Therapy, Vol. 8, Issue 3
Burkholderia vaccines: are we moving forward?
journal, January 2013
- Choh, Leang-Chung; Ong, Guang-Han; Vellasamy, Kumutha M.
- Frontiers in Cellular and Infection Microbiology, Vol. 3
Biological activities of lipopolysaccharide of Burkholderia (Pseudomonas) pseudomallei
journal, March 1996
- Matsuura, Motohiro; Kawahara, Kazuyoshi; Ezaki, Takayuki
- FEMS Microbiology Letters, Vol. 137, Issue 1
Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis
journal, January 2016
- Limmathurotsakul, Direk; Golding, Nick; Dance, David A. B.
- Nature Microbiology, Vol. 1, Issue 1
Facile Synthesis ofα- andβ-O-Glycosyl Imidates; Preparation of Glycosides and Disaccharides
journal, September 1980
- Schmidt, Richard R.; Michel, Josef
- Angewandte Chemie International Edition in English, Vol. 19, Issue 9
Burkholderia thailandensis oacA Mutants Facilitate the Expression of Burkholderia mallei -Like O Polysaccharides
journal, November 2010
- Brett, Paul J.; Burtnick, Mary N.; Heiss, Christian
- Infection and Immunity, Vol. 79, Issue 2
Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans
journal, April 2016
- Broecker, Felix; Hanske, Jonas; Martin, Christopher E.
- Nature Communications, Vol. 7, Issue 1
Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders
journal, July 2015
- Moustafa, Dina A.; Scarff, Jennifer M.; Garcia, Preston P.
- PLOS ONE, Vol. 10, Issue 7
Surface plasmon resonance for the characterization of bacterial polysaccharide antigens: a review
journal, January 2014
- Brogioni, Barbara; Berti, Francesco
- MedChemComm, Vol. 5, Issue 8
Bioterrorism and the Role of the Clinical Microbiology Laboratory
journal, December 2015
- Wagar, Elizabeth
- Clinical Microbiology Reviews, Vol. 29, Issue 1
Burkholderia vaccines: are we moving forward?
journal, January 2013
- Choh, Leang-Chung; Ong, Guang-Han; Vellasamy, Kumutha M.
- Frontiers in Cellular and Infection Microbiology, Vol. 3
Specificity and functional activity of anti-Burkholderia pseudomallei polysaccharide antibodies.
journal, January 1997
- Ho, M.; Schollaardt, T.; Smith, M. D.
- Infection and immunity, Vol. 65, Issue 9
Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates.
journal, January 1996
- Brett, P. J.; Woods, D. E.
- Infection and immunity, Vol. 64, Issue 7
Structural characterization of the lipopolysaccharide O antigens of Burkholderia pseudomallei.
journal, January 1995
- Perry, M. B.; MacLean, L. L.; Schollaardt, T.
- Infection and immunity, Vol. 63, Issue 9
Works referencing / citing this record:
Potential targets for next generation antimicrobial glycoconjugate vaccines
journal, March 2018
- Micoli, Francesca; Costantino, Paolo; Adamo, Roberto
- FEMS Microbiology Reviews, Vol. 42, Issue 3
Recent Advances in the Chemistry of Glycoconjugate Amphiphiles
journal, January 2018
- Latxague, Laurent; Gaubert, Alexandra; Barthélémy, Philippe
- Molecules, Vol. 23, Issue 1
Potential targets for next generation antimicrobial glycoconjugate vaccines
journal, March 2018
- Micoli, Francesca; Costantino, Paolo; Adamo, Roberto
- FEMS Microbiology Reviews, Vol. 42, Issue 3
Development of an immunoblotting assay for serodiagnosis of Burkholderia mallei infection: the whole-cell proteome-based paradigm
journal, August 2019
- Yazdansetad, Sajjad; Mosavari, Nader; Mosavari, Nader
- Iranian Journal of Microbiology
Melioidosis patient serum-reactive synthetic tetrasaccharides bearing the predominant epitopes of Burkholderia pseudomallei and Burkholderia mallei O-antigens
journal, January 2019
- Cloutier, Maude; Delar, Emmanilo; Muru, Kevin
- Organic & Biomolecular Chemistry, Vol. 17, Issue 39
Polysaccharides from Burkholderia species as targets for vaccine development, immunomodulation and chemical synthesis
journal, January 2018
- Cloutier, Maude; Muru, Kevin; Ravicoularamin, Gokulakrishnan
- Natural Product Reports, Vol. 35, Issue 12
Comment on “Zemplén transesterification: a name reaction that has misled us for 90 years” by B. Ren, M. Wang, J. Liu, J. Ge, X. Zhang and H. Dong, Green Chemistry , 2015, 17 , 1390–1394
journal, January 2018
- Pezzetta, Cristofer; Tshepelevitsh, Sofja; Leito, Ivo
- Green Chemistry, Vol. 20, Issue 10
Synthesis, cytotoxicity and anti-inflammatory activity of rhamnose-containing ursolic and betulinic acid saponins
journal, January 2019
- Sylla, Balla; Lavoie, Serge; Legault, Jean
- RSC Advances, Vol. 9, Issue 68
Glycoconjugate vaccines: current approaches towards faster vaccine design
journal, August 2019
- Micoli, Francesca; Del Bino, Linda; Alfini, Renzo
- Expert Review of Vaccines, Vol. 18, Issue 9
A Burkholderia pseudomallei Outer Membrane Vesicle Vaccine Provides Cross Protection against Inhalational Glanders in Mice and Non-Human Primates
journal, December 2017
- Baker, Sarah; Davitt, Christopher; Motyka, Natalya
- Vaccines, Vol. 5, Issue 4
Outer Membrane Vesicle Vaccines from Biosafe Surrogates Prevent Acute Lethal Glanders in Mice
journal, January 2018
- Norris, Michael; Khan, Mohammad; Chirakul, Sunisa
- Vaccines, Vol. 6, Issue 1